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Formyl peptide receptor-like receptors: an olfactory tool to identify pathogens?

English title Formyl peptide receptor-like receptors: an olfactory tool to identify pathogens?
Applicant Rodriguez Ivan
Number 135910
Funding scheme Project funding (Div. I-III)
Research institution Département de Génétique et Evolution Faculté des Sciences Université de Genève
Institution of higher education University of Geneva - GE
Main discipline Genetics
Start/End 01.05.2011 - 31.10.2014
Approved amount 389'748.00
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All Disciplines (3)

Discipline
Genetics
Embryology, Developmental Biology
Molecular Biology

Lay Summary (English)

Lead
Lay summary

Most mammals rely heavily on conspecific chemical communication mechanisms to interact adequately with each other. They utilize different types of seven-transmembrane G protein-coupled receptors to identify both general odorants and pheromones. Using a mouse model, we recently discovered that members of the formyl peptide receptor (FPR) family are exclusively expressed in sensory neurons of the vomeronasal organ. We identified agonists for these receptors, and observed that most of these FPR ligands are linked to pathogens and / or pathogenic states. Moreover, we demonstrated that subpopulations of vomeronasal neurons do respond to these agonists. Based on these exciting findings, we propose here to investigate a) the in vivo agonist response profile of genetically engineered vomeronasal sensory neurons expressing a defined FPR receptor, b) the transduction cascade triggered downstream FPR activation, and c) the functional role of the vomeronasal system in the discrimination of unhealthy individuals in mice.

Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

Employees

Publications

Publication
The vomeronasal system mediates sick conspecific avoidance.
Boillat Madlaina, Challet Ludivine, Rossier Daniel, Kan Chenda, Carleton Alan, Rodriguez Ivan (2015), The vomeronasal system mediates sick conspecific avoidance., in Current biology : CB, 25(2), 251-5.
Physiological characterization of formyl peptide receptor expressing cells in the mouse vomeronasal organ.
Ackels Tobias, von der Weid Benoît, Rodriguez Ivan, Spehr Marc (2014), Physiological characterization of formyl peptide receptor expressing cells in the mouse vomeronasal organ., in Frontiers in neuroanatomy, 8, 134-134.
Convergence of FPR-rs3-expressing neurons in the mouse accessory olfactory bulb.
Dietschi Quentin, Assens Alexis, Challet Ludivine, Carleton Alan, Rodriguez Ivan (2013), Convergence of FPR-rs3-expressing neurons in the mouse accessory olfactory bulb., in Molecular and cellular neurosciences, 56, 140-7.
In-depth analysis of defined cell populations in acute tissue slices of the mouse vomeronasal organ
Ackels T. Drose DR. Spehr M., In-depth analysis of defined cell populations in acute tissue slices of the mouse vomeronasal organ, in the journal of visualized experiments.

Communication with the public

Communication Title Media Place Year
Media relations: print media, online media découverte à l'UniGe: des neurones qui détectent la maladie 24 heures Western Switzerland 2015
Media relations: print media, online media découverte de neurones qui détectent la maladie sciences et avenir Santé International 2015
Media relations: print media, online media des neurones détectend les maladies des autres Tribune de Genève Western Switzerland 2015
Media relations: print media, online media El secreto de los ratones que "huelen" la enfermedad vozpopuli.com International 2015
Media relations: print media, online media In mouse model, neurons that detect disease enable them to avoid their sick peers International 2015
Media relations: print media, online media la souris capable de flairer la maladie Le Temps Western Switzerland 2015
Media relations: print media, online media Mäuse riechen kranke Artgenossen NZZ German-speaking Switzerland 2015
Media relations: print media, online media Neurons that detect disease science daily International 2015
Media relations: print media, online media Neurons That Detect Disease science news online International 2015
Media relations: print media, online media Neurons that detect disease: Study reveals how mice avoid their sick peers phys.org International 2015

Associated projects

Number Title Start Funding scheme
149753 Emergence and regulation of vomeronasal receptor genes in the mouse 01.10.2013 Project funding (Div. I-III)

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