sodium; kidney; cirrhosis; cholestasis; ENaC; Na; K-ATPase
Pruijm M Ponte B Ackermann D Paccaud F Guessous I Ehret G Pechère-Bertschi A Vogt B Mohaupt (2016), Associations of Urinary Uromodulin with Clinical Characteristics and Markers of Tubular Function in the General Population., in Clin J Am Soc Nephrol
, 11(1), 70-80.
Vogt B (2016), Chronic kidney disease in the Swiss population, in Swiss Med Wkly
, 146(14319), 1.
Seif M Mani LY Lu H Boesch C Reyes M Vogt B Vermathen P. (2016), Diffusion tensor imaging of the human kidney: Does image registration permit scanning without respiratory triggering?, in J Magn Reson Imaging
, 44(2), 327-334.
Dhayat NA Ackermann D Pruijm M Ponte B Ehret G Guessous I Leichtle AB Paccaud F Mohaupt M F (2016), Fibroblast growth factor 23 and markers of mineral metabolism in individuals with preserved renal function., in Kidney Int
, 90(3), 648.
Dhayat N Simonin A Anderegg M Pathare G Lüscher BP Deisl C Albano G Mordasini D Hediger MA (2016), Mutation in the Monocarboxylate Transporter 12 Gene Affects Guanidinoacetate Excretion but Does Not Cause Glucosuria, in J Am Soc Nephrol
, 5, 1426-1436.
Udwan K Brideau G Fila M Edwards A Vogt B Doucet A. (2016), Oxidative Stress and Nuclear Factor κB (NF-κB) Increase Peritoneal Filtration and Contribute to Ascites Formation in Nephrotic Syndrome., in J Biol Chem
, 291(21), 11105-11113.
Messerli FH1 Rimoldi SF1 Vogt B2. (2016), Quo usque tandem abutere, Catilina, patientia nostra?, in Swiss Med Wkly
, 146, 14344.
Petrovic D(1) Estoppey Younes S(1) Pruijm M(2) Ponte B(3) Ackermann D(4) (2016), Relation of 24-hour urinary caffeine and caffeine metabolite excretions with, in Nutr Metab
, 13, 81.
Seif M Eisenberger U Binser T Thoeny HC Krauer F Rusch A Boesch C Vogt B Vermathen P. (2016), Renal Blood Oxygenation Level-dependent Imaging in Longitudinal Follow-up of Donated and Remaining Kidneys., in Radiology
, 279(3), 795-804.
Petrovic D Pivin E Ponte B Dhayat N Pruijm M Ehret G Ackermann D Guessous I Younes SE Pechè (2016), Sociodemographic, behavioral and genetic determinants of allostatic load in a Swiss population-based study., in Psychoneuroendocrinology
, 67, 78-85.
Dhayat NA Schaller A Albano G Poindexter J Griffith C Pasch A Gallati S Vogt B Moe OW Fuste (2016), The Vacuolar H+-ATPase B1 Subunit Polymorphism p.E161K Associates with Impaired Urinary Acidification in Recurrent Stone Formers., in J Am Soc Nephrol
, 5, 1426-1436.
Piskunowicz M Hofmann L Zuercher E Bassi I Milani B Stuber M Narkiewicz K Vogt B Burnier M (2015), A new technique with high reproducibility to estimate renal oxygenation using BOLD-MRI in chronic kidney disease., in Magn Reson Imaging
, 33(3), 253-261.
Guessous I Pruijm M Ponte B Ackermann D Ehret G Ansermot N Vuistiner P Staessen J Gu Y Pacc (2015), Associations of ambulatory blood pressure with urinary caffeine and caffeine metabolite excretions., in Hypertension
, 65(3), 691-696.
Ponte B Pruijm M Ackermann D Vuistiner P Guessous I Ehret G Alwan H Youhanna S Paccaud F Mo (2015), Copeptin is associated with kidney length, renal function, and prevalence of simple cysts in a population-based study., in J Am Soc Nephrol
, 6, 1415-1425.
Ackermann D Pruijm M Ponte B Guessous I Ehret G Escher G Dick B Al-Alwan H Vuistiner P Pacc (2015), CYP17A1 Enzyme Activity Is Linked to Ambulatory Blood Pressure in a Family-Based Population Study., in Am J Hypertens
, 4, 484-493.
Mordasini D Loffing-Cueni D Loffing J Beatrice R Maillard MP Hummler E Burnier M Escher G Vo (2015), ENaC activity in collecting ducts modulates NCC in cirrhotic mice., in Pflugers Arch
, 467(12), 2529-2539.
Dhayat NA Frey AC Frey BM d'Uscio CH Vogt B Rousson V Dick B Flück CE. (2015), Estimation of reference curves for the urinary steroid metabolome in the first year of life in healthy children: Tracing the complexity of human postnatal steroidogenesis., in J Steroid Biochem Mol Biol
, 154, 226-236.
Alwan H Ehret G Ponte B Pruijm M Ackermann D Guessous I Staessen JA Asayama K Kutalik Z Vui (2015), Heritability of ambulatory and office blood pressure in the Swiss population., in J Hypertens
, 10, 2061-2067.
Mani LY Huynh-Do U Vogt B Ackermann D. (2015), IgA-Nephropathie und Purpura Schönlein-Henoch - ein breites Spektrum., in Ther Umsch
, 72(3), 157-160.
Pivin E Ponte B Pruijm M Ackermann D Guessous I Ehret G Liu YP Drummen NE Knapen MH Pechere (2015), Inactive Matrix Gla-Protein Is Associated With Arterial Stiffness in an Adult Population-Based Study., in Hypertension
, 66(1), 85-92.
Mani LY Kissling S Viceic D Vogt B Burnier M Buclin T Renard D. (2015), Intermittent hemodialysis treatment in cefepime-induced neurotoxicity: case report, pharmacokinetic modeling, and review of the literature., in Hemodial Int
, 2, 333-343.
Vogt B. (2015), New insights in ACE-independent angiotensin II production., in Exp Physiol
, 100(9), 992.
Vogt B. (2015), Patient safety in vascular access patients on hemodialysis: contrast agents and renal function., in Contrib Nephrol
, 184, 51-58.
Kissling S Fuchs A Gobin N Vogt B Burnier M Decosterd LA Buclin T Livio F. (2015), Pharmacokinetic modelling of dialytic clearance in a case of acyclovir intoxication., in Int J Antimicrob Agents
, 45(3), 325-327.
Daikeler T Kistler AD Martin PY Vogt B Huynh-Do U. (2015), The role of rituximab in the treatment of ANCA-associated vasculitides (AAV)., in Swiss Med Wkly
, 145, 14103.
Piazzon N Bernet F Guihard L Leonhard WN Urfer S Firsov D Chehade H Vogt B Piergiovanni S P (2015), Urine Fetuin-A is a biomarker of autosomal dominant polycystic kidney disease progression., in J Transl Med
, 13, 103.
Bodenmann Gobin P Gobin N Ducry J Portmann L Vial Y Vogt B (2014), [Electrolyte disorders in preeclampsia. A case report].
, Nephrol Ther. 2014 Feb;10(1):51-7, Genève.
Pruijm M Hofmann L Piskunowicz M Muller ME Zweiacker C Bassi I Vogt B Stuber M Burnier M (2014), Determinants of renal tissue oxygenation as measured with BOLD-MRI in chronic kidney disease and hypertension in humans., in PLoS One
, 23(9), e95895-e95895.
Zurkinden L Solcà C Vögeli IA Vogt B Ackermann D Erickson SK Frey FJ Sviridov D Escher G (2014), Effect of Cyp27A1 gene dosage on atherosclerosis development in ApoE-knockout mice, in FASEB J
, 28(3), 1198-1209.
Alwan H Pruijm M Ponte B Ackermann D Guessous I Ehret G Staessen JA Asayama K Vuistiner P Y (2014), Epidemiology of masked and white-coat hypertension: the family-based SKIPOGH study., in PLoS One.
, 24(3), e92522-e92522.
Mani LY Kissling S Viceic D Vogt B Burnier M Buclin T Renard D (2014), Intermittent hemodialysis treatment in cefepime-induced neurotoxicity: Case report, pharmacokinetic modeling, and review of the literature., in Hemodial Int.
, 2, 333-343.
Tokonami N Mordasini D Pradervand S Centeno G Jouffe C Maillard M Bonny O Gachon F Gomez RA (2014), Local renal circadian clocks control fluid-electrolyte homeostasis and BP, in J Am Soc Nephrol
, 25(7), 1430-1439.
Ponte B Pruijm M Ackermann D Vuistiner P Eisenberger U Guessous I Rousson V Mohaupt MG Alwan (2014), Reference values and factors associated with renal resistive index in a family-based population study., in Hypertension
, 63(1), 136-142.
Rezaei M Andrieu T Neuenschwander S Bruggmann R Mordasini D Frey FJ Vogt B Frey BM (2014), Regulation of 11β-Hydroxysteroid Dehydrogenase Type 2 by MicroRNA., in Hypertension
, 64(4), 860-866.
Phan O El Housseini Y Burnier M Vogt B. (2013), [Kidney and smoking: literature review and focus]., in Ther Umsch
, 9(2), 67-72.
Pruijm M Hofmann L Zanchi A Maillard M Forni V Muller ME Wuerzner G Vogt B Stuber M Burnier (2013), Blockade of the renin-angiotensin system and renal tissue oxygenation as measured with BOLD-MRI in patients with type 2 diabetes., in Diabetes Res Clin Pract
, 99(2), 136-144.
Trudu M1 Janas S Lanzani C Debaix H Schaeffer C Ikehata M Citterio L Demaretz S Trevisani F (2013), Common noncoding UMOD gene variants induce salt-sensitive hypertension and kidney damage by increasing uromodulin expression., in Nat Med
, 19(12), 1655-1660.
Pruijm M Hofmann L Charollais-Thoenig J Forni V Maillard M Coristine A Stuber M Burnier M Vo (2013), Effect of dark chocolate on renal tissue oxygenation as measured by BOLD-MRI in healthy volunteers., in Clin Nephrol
, 80(3), 211-217.
Pruijm M Hofmann L Vogt B Muller ME Piskunowicz M Stuber M Burnier M. (2013), Renal tissue oxygenation in essential hypertension and chronic kidney disease., in Int J Hypertens
, 2013, 696598.
Tokonami N1 Morla L Centeno G Mordasini D Ramakrishnan SK Nikolaeva S Wagner CA Bonny O Houi (2013), α-Ketoglutarate regulates acid-base balance through an intrarenal paracrine mechanism, in J Clin Invest
, 123(7), 3166-3171.
Vogt B Maillard M Burnier M (2012), [Hypertension therapy in patients with renal artery stenosis]., in Ther Umsch
, 69(5), 279-281.
Riesen WF Virgini V Vogt B Rodondi N. (2012), [New european guidelines for dyslipidemia]., in Rev Med Suisse
, 8(331), 525-530.
Kissling S Wilson P Ridel C Burnier M Vogt B. (2012), [What reasonable applications for regional citrate anticoagulation in renal replacement therapy?]., in Rev Med Suisse
, 8(330), 452-456.
Schneider AG Hofmann L Wuerzner G Glatz N Maillard M Meuwly JY Eggimann P Burnier M Vogt B (2012), Renal perfusion evaluation with contrast-enhanced ultrasonography., in Nephrol Dial Transplant
, 27(2), 674-681.
Pruijm M Ponte B Hofmann L Vogt B Eisenberger U Meuwly JY Burnier M (2011), [New radiological techniques to investigate patients suffering from chronic kidney disease]., in Rev med Suisse
, 7(284), 505-509.
Mani LY Vogt B Burnier M Golshayan D. (2011), [Rationale and clinical evidence for the use of rituximab in glomerular diseases]., in Rew Med Suisse
, 13(7), 819-824.
Dhayat NA Dick B Frey BM d'Uscio CH Vogt B Flück CE., Androgen biosynthesis during minipuberty favors the backdoor pathway over the classic pathway: Insights into enzyme activities and steroid fluxes in healthy infants during the first year of life from, in J Steroid Biochem Mol Biol
Milani B12 Ansaloni A1 Sousa-Guimaraes S1 Vakilzadeh N1 Piskunowicz M3 Vogt B4 Stuber M25 B, Reduction of cortical oxygenation in chronic kidney disease: evidence obtained with a new analysis method of blood oxygenation level-dependent magnetic resonance imaging., in Nephrol Dial Transplant
Cirrhosis, most of it related to alcohol abuse or viral hepatitis, is a frequent and severe disease complicated by abnormal renal Na+ retention with edema and ascites formation. The renal mechanisms as well as the ions transporters involved in Na+ retention are still debated. In order to shed some light on these topics, we decided to take advantage of the transgenesis possibilities offered by the existing tissues specific knock-out (KO) mice to develop candidate gene approaches. In our first previous study, we transposed successfully the well known bile duct ligation (BDL) induced cirrhosis model into mice. Our results showed that BDL induced cirrhotic mice compared to sham-operated animals had an increased renal Na+ retention and an increased Na,K-ATPase activity in the cortical collecting duct (CCD) exclusively, independently of corticoids stimulation. These results suggested that an unknown, “adrenal independent” and CCD specific mechanism is altering the Na,K-ATPase activity in decompensate cirrhosis. In order to shed some light on this mechanism we decided, for the actual study, to suppress the expression of the main Na+ entry of the CCD, the amiloride sensitive Na+ channel (ENaC). We developed a new model of cholestatic mice with CCD specific ?ENaC KO. These mice offer a unique opportunity to assess the role of ENaC in renal Na+ retention in cholestatic mice. Surprisingly, we observed non difference between CCD specific ?ENaC KO and CTL mice in term of Na+ retention, ascites formation, or Na,K-ATPase activity. ?ENaC suppression in the CCD was confirmed by immunofluorescence. These results showed that a this unknown mechanism altering the Na,K-ATPase in the CCD, is independent of ENaC function, suggesting once again the existence of a new mechanism of Na+ transport relevant in cholestatic conditions.Based on the hypothesis that a new mechanism for Na+ entering on the luminal side of the CCD act in cholestatic conditions. In this grant proposal, I propose to investigate in details this new mechanism in order to identify the transporter responsible for this ENaC independent Na+ transport. This question will be addressed in cholestatic and control mice with selective ?-ENaC knockout in the CCD by: 1.Metabolic analysis of the bile duct ligated induced cirrhosis mouse model2.Measurement of the Na,K-ATPase activity in the CCD of BDL induced cirrhotic mice in preascitic stage 3.Analyzing the influence of Na+ intake on Na,K-ATPase activity in the CCD of CCD specific ?ENac KO mice4.Analyses of the Na+-dependent Cl-/HCO3- exchanger and the pendrin, described recently, as a candidate mechanism by in vitro microperfusion, in collaboration with the Dr. A. Doucet’s lab in Paris.5.Transcriptomic analysis by microarray of the whole kidney and COPAS sorted CCD from BDL induced cirrhotic mice, in collaboration with the Lausanne DNA array Facility6.Kidney immunohistochemistry of candidate genes, in collaboration with Prof. J. Loffing in ZurichThe identification of new mechanism(s) for Na+ entering on the luminal side of the CCD and/or new mechanism(s) for activation of Na,K-ATPase activity on the basolateral side in cholestatic conditions, will provide important new insights on aldosterone independent and adrenal independent regulation of Na+ transport in the CCD in cholestatic cirrhosis and in general physiology and pathophysiology.