Crop lossesto pests and disease continue to reduce production of food worldwide. Theefficacy of crop protection practices depends on early detection and thisproject aims to develop nano-biosensors for this purpose. The antennal sensorysystem of plant-feeding insects shows very high sensitivity to quite a range oforganic molecules such as plant metabolites. This research programme aims atharnessing components of the insect sensory apparatus to develop a nano-biosensorfor marker molecules of crop disease. High levels of small soluble proteinssurround sensory neurones on the insect antenna. As these proteins reversiblybind odorants with dissociation constants in the micro molar range they areideally suited for use as sensor-proteins. We plan to use inter-digitated arraymicroelectrodes of a liquid ion-gate field effect transistor or organicfield-effect transistors, functionalized with the odour binding proteins, asmicroelectronic readout devices. Specific binding of odour molecules will generateconformational changes in the odorant binding proteins that will affect thesource-drain current of the transistors. Findings from this research project willlead to novel bio-inspired sensors expected to achieve levels of detection forplant metabolites down to the femto Molar level or better and with low-costreliable operation. The research relies on the expertise of researchers from 5European countries working together within a highly interrelated network on insectolfactory systems and neurobiology, surface chemistry, biosensornanofabrication, microelectronics, signal processing and informatics.