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Swiss HIV Cohort Study (SHCS)

English title Swiss HIV Cohort Study (SHCS)
Applicant Günthard Huldrych Fritz
Number 134277
Funding scheme Cohort Studies Large
Research institution Klinik für Infektionskrankheiten und Spitalhygiene Universitätsspital Zürich
Institution of higher education University of Zurich - ZH
Main discipline Internal Medicine
Start/End 01.01.2011 - 31.12.2013
Approved amount 9'750'000.00
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All Disciplines (2)

Discipline
Internal Medicine
Infectious Diseases

Keywords (6)

HIV; Immune deficiency; Antiretroviral therapy; AIDS; cohort; epidemiology

Lay Summary (English)

Lead
Lay summary
The Swiss HIV Cohort Study (SHCS) was established in 1988 with the help of the Swiss Federal Office of Public Health. Since several years, the study is funded by the Swiss National Science Foundation (SNSF). It is an observational study of HIV-infected residents in Switzerland aged 18 years or older. The study is a collaboration of seven centers (the five Swiss university hospitals situated in Basel, Bern, Geneva, Lausanne and Zurich, and two reference hospitals in St.Gallen and Lugano), 14 regional hospitals and more than 30 private physicians. It is managed by the Co-ordination and Data center in Lausanne and is estimated to cover about 68% of people with AIDS living in Switzerland and 51% of the cumulated number of HIV infections declared to the Swiss health authorities.Objectives The study serves as a logistical network for research in the field of HIV. Objectives include epidemiological-, clinical-, laboratory- and health service research, as well as improving service and infrastructure for future projects. An important number of nested research projects are performed in this framework. These projects benefit of the infrastructure, collected data and stored blood samples and a majority is financed by the funds allocated by the SNSF.Data collectionA standardized protocol is used for data collection. A variety of data are recorded at entry to the study, i.e. year of birth, gender and presumed mode of transmission. Categories of presumed transmission include men having sex with men, heterosexually infected patients, injecting drug users, patients infected via blood products and patients with unknown route of infection. Laboratory and clinical data are obtained at each semi-annual follow-up visit. Additional interim CD3/4/8 and viral load determinations are recorded, if available. Some serological laboratory tests are carried out at registration. The antiretroviral treatment is documented in detail. Information that has become relevant in later years has been added to the study protocol (i.e. adverse events of antiretroviral drugs, adherence to drug therapy, cardiovascular risk factors, and concomitant diseases). Data quality is regularly checked by the data center and a quality incentive system is in place in which centers with insufficient data quality are motivated with deductions from the financial support. The data collection is strictly anonymous and informed consent is obtained at registration.Routine analyses are carried out regularly and include trends in transmission mode and gender, number of registrations and of patients under follow-up, type of health care provider as well as antiretroviral treatment
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

Employees

Publications

Publication
Adherence as a predictor of the development of class-specific resistance mutations: the Swiss HIV Cohort Study.
von Wyl Viktor, Klimkait Thomas, Yerly Sabine, Nicca Dunja, Furrer Hansjakob, Cavassini Matthias, Calmy Alexandra, Bernasconi Enos, Böni Jürg, Aubert Vincent, Günthard Huldrych F, Bucher Heiner C, Glass Tracy R, Glass Tracy R (2013), Adherence as a predictor of the development of class-specific resistance mutations: the Swiss HIV Cohort Study., in PloS one, 8(10), 77691-77691.
Association study of common genetic variants and HIV-1 acquisition in 6,300 infected cases and 7,200 controls.
McLaren Paul J, Coulonges Cédric, Ripke Stephan, van den Berg Leonard, Buchbinder Susan, Carrington Mary, Cossarizza Andrea, Dalmau Judith, Deeks Steven G, Delaneau Olivier, De Luca Andrea, Goedert James J, Haas David, Herbeck Joshua T, Kathiresan Sekar, Kirk Gregory D, Lambotte Olivier, Luo Ma, Mallal Simon, van Manen Daniëlle, Martinez-Picado Javier, Meyer Laurence, Miro José M, Mullins James I, Obel Niels, O'Brien Stephen J, Pereyra Florencia, Plummer Francis A, Poli Guido, Qi Ying, Rucart Pierre, Sandhu Manj S, Shea Patrick R, Schuitemaker Hanneke, Theodorou Ioannis, Vannberg Fredrik, Veldink Jan, Walker Bruce D, Weintrob Amy, Winkler Cheryl A, Wolinsky Steven, Telenti Amalio, Goldstein David B, de Bakker Paul I W, Zagury Jean-François, Fellay Jacques (2013), Association study of common genetic variants and HIV-1 acquisition in 6,300 infected cases and 7,200 controls., in PLoS pathogens, 9(7), 1003515-1003515.
Free and total plasma levels of lopinavir during pregnancy, at delivery and postpartum: implications for dosage adjustments in pregnant women.
Fayet-Mello Aurélie, Buclin Thierry, Guignard Nicole, Cruchon Sandra, Cavassini Matthias, Grawe Claudia, Gremlich Erika, Popp Karoline Aebi, Schmid Flavia, Eap Chin B, Telenti Amalio, Biollaz Jérôme, Decosterd Laurent A, Martinez de Tejada Begoña, Martinez de Tejada Begoña, Martinez de Tejada Begoña (2013), Free and total plasma levels of lopinavir during pregnancy, at delivery and postpartum: implications for dosage adjustments in pregnant women., in Antiviral therapy, 18(2), 171-82.
HIV infection disrupts the sympatric host-pathogen relationship in human tuberculosis.
Fenner Lukas, Egger Matthias, Bodmer Thomas, Furrer Hansjakob, Ballif Marie, Battegay Manuel, Helbling Peter, Fehr Jan, Gsponer Thomas, Rieder Hans L, Zwahlen Marcel, Hoffmann Matthias, Bernasconi Enos, Cavassini Matthias, Calmy Alexandra, Dolina Marisa, Frei Reno, Janssens Jean-Paul, Borrell Sonia, Stucki David, Schrenzel Jacques, Böttger Erik C, Gagneux Sebastien, Gagneux Sebastien (2013), HIV infection disrupts the sympatric host-pathogen relationship in human tuberculosis., in PLoS genetics, 9(3), 1003318-1003318.
Low levels of mannan-binding lectin or ficolins are not associated with an increased risk of cytomegalovirus disease in HIV-infected patients.
Egli Adrian, Schäfer Juliane, Osthoff Michael, Thiel Steffen, Mikkelsen Christina, Rauch Andri, Hirsch Hans H, Bucher Heiner C, Young James, Jensenius Jens C, Battegay Manuel, Trendelenburg Marten, Trendelenburg Marten (2013), Low levels of mannan-binding lectin or ficolins are not associated with an increased risk of cytomegalovirus disease in HIV-infected patients., in PloS one, 8(1), 51983-51983.
Micro-structural brain alterations in aviremic HIV+ patients with minor neurocognitive disorders: a multi-contrast study at high field.
Granziera Cristina, Daducci Alessandro, Simioni Samanta, Cavassini Matthias, Roche Alexis, Meskaldji Djalel, Kober Tobias, Metral Melanie, Calmy Alexandra, Helms Gunther, Hirschel Bernard, Lazeyras François, Meuli Reto, Krueger Gunnar, Du Pasquier Renaud A (2013), Micro-structural brain alterations in aviremic HIV+ patients with minor neurocognitive disorders: a multi-contrast study at high field., in PloS one, 8(9), 72547-72547.
National Guidelines for the prevention of mother-to-child transmission of HIV across Europe - how do countries differ?
Aebi-Popp Karoline, Mulcahy Fiona, Rudin Christoph, Hoesli Irene, Gingelmaier Andrea, Lyons Fiona, Thorne Claire (2013), National Guidelines for the prevention of mother-to-child transmission of HIV across Europe - how do countries differ?, in European journal of public health, 23(6), 1053-8.
Risk factors and outcomes for late presentation for HIV-positive persons in Europe: results from the Collaboration of Observational HIV Epidemiological Research Europe Study (COHERE).
Mocroft Amanda, Lundgren Jens D, Sabin Miriam Lewis, Monforte Antonella d'Arminio, Brockmeyer Norbert, Casabona Jordi, Castagna Antonella, Costagliola Dominique, Dabis Francois, De Wit Stéphane, Fätkenheuer Gerd, Furrer Hansjakob, Johnson Anne M, Lazanas Marios K, Leport Catherine, Moreno Santiago, Obel Niels, Post Frank A, Reekie Joanne, Reiss Peter, Sabin Caroline, Skaletz-Rorowski Adriane, Suarez-Lozano Ignacio, Torti Carlo, Warszawski Josiane, Zangerle Robert, Fabre-Colin Céline, Kjaer Jesper, Chene Genevieve, Grarup Jesper, Kirk Ole, Kirk Ole (2013), Risk factors and outcomes for late presentation for HIV-positive persons in Europe: results from the Collaboration of Observational HIV Epidemiological Research Europe Study (COHERE)., in PLoS medicine, 10(9), 1001510-1001510.
Simple estimation of incident HIV infection rates in notification cohorts based on window periods of algorithms for evaluation of line-immunoassay result patterns.
Schüpbach Jörg, Gebhardt Martin D, Scherrer Alexandra U, Bisset Leslie R, Niederhauser Christoph, Regenass Stephan, Yerly Sabine, Aubert Vincent, Suter Franziska, Pfister Stefan, Martinetti Gladys, Andreutti Corinne, Klimkait Thomas, Brandenberger Marcel, Günthard Huldrych F, Günthard Huldrych F (2013), Simple estimation of incident HIV infection rates in notification cohorts based on window periods of algorithms for evaluation of line-immunoassay result patterns., in PloS one, 8(8), 71662-71662.
TB meningitis in HIV-positive patients in Europe and Argentina: clinical outcome and factors associated with mortality.
Efsen Anne Marie W, Panteleev Alexander M, Grint Daniel, Podlekareva Daria N, Vassilenko Anna, Rakhmanova Aza, Zeltina Indra, Losso Marcelo H, Miller Robert F, Girardi Enrico, Caylá Joan, Post Frank A, Miro Jose M, Bruyand Mathias, Furrer Hansjakob, Obel Niels, Lundgren Jens D, Mocroft Amanda, Kirk Ole, Kirk Ole (2013), TB meningitis in HIV-positive patients in Europe and Argentina: clinical outcome and factors associated with mortality., in BioMed research international, 2013, 373601-373601.
The immunological and virological consequences of planned treatment interruptions in children with HIV infection.
Klein Nigel, Sefe Delali, Mosconi Ilaria, Zanchetta Marisa, Castro Hannah, Jacobsen Marianne, Jones Hannah, Bernardi Stefania, Pillay Deenan, Giaquinto Carlo, Walker A Sarah, Gibb Diana M, De Rossi Anita, De Rossi Anita (2013), The immunological and virological consequences of planned treatment interruptions in children with HIV infection., in PloS one, 8(10), 76582-76582.
The individualized genetic barrier predicts treatment response in a large cohort of HIV-1 infected patients.
Beerenwinkel Niko, Montazeri Hesam, Schuhmacher Heike, Knupfer Patrick, von Wyl Viktor, Furrer Hansjakob, Battegay Manuel, Hirschel Bernard, Cavassini Matthias, Vernazza Pietro, Bernasconi Enos, Yerly Sabine, Böni Jürg, Klimkait Thomas, Cellerai Cristina, Günthard Huldrych F, Günthard Huldrych F (2013), The individualized genetic barrier predicts treatment response in a large cohort of HIV-1 infected patients., in PLoS computational biology, 9(8), 1003203-1003203.
The prevalence of erectile dysfunction and its association with antiretroviral therapy in HIV-infected men: the Swiss HIV Cohort Study.
Wang Qing, Young Jim, Bernasconi Enos, Cavassini Matthias, Vernazza Pietro, Hirschel Bernard, Weber Rainer, Furrer Hansjakob, Stoeckle Marcel, Bucher Heiner C, Fux Christoph, Fux Christoph (2013), The prevalence of erectile dysfunction and its association with antiretroviral therapy in HIV-infected men: the Swiss HIV Cohort Study., in Antiviral therapy, 18(3), 337-44.
Virologic and immunologic response to cART by HIV-1 subtype in the CASCADE collaboration.
Touloumi Giota, Pantazis Nikos, Chaix Marie-Laure, Bucher Heiner C, Zangerle Robert, Kran Anne-Marte Bakken, Thiebaut Rodolphe, Masquelier Bernard, Kucherer Claudia, Monforte Antonella d'Arminio, Meyer Laurence, Porter Kholoud, Porter Kholoud (2013), Virologic and immunologic response to cART by HIV-1 subtype in the CASCADE collaboration., in PloS one, 8(7), 71174-71174.
Genetic interplay between HLA-C and MIR148A in HIV control and Crohn disease.
Kulkarni Smita, Qi Ying, O'hUigin Colm, Pereyra Florencia, Ramsuran Veron, McLaren Paul, Fellay Jacques, Nelson George, Chen Haoyan, Liao Wilson, Bass Sara, Apps Richard, Gao Xiaojiang, Yuki Yuko, Lied Alexandra, Ganesan Anuradha, Hunt Peter W, Deeks Steven G, Wolinsky Steven, Walker Bruce D, Carrington Mary (2013), Genetic interplay between HLA-C and MIR148A in HIV control and Crohn disease., in Proceedings of the National Academy of Sciences of the United States of America, 110(51), 20705-10.
Association of alcohol consumption and HIV surrogate markers in participants of the swiss HIV cohort study.
Conen Anna, Wang Qing, Glass Tracy R, Fux Christoph A, Thurnheer Maria C, Orasch Christina, Calmy Alexandra, Bernasconi Enos, Vernazza Pietro, Weber Rainer, Bucher Heiner C, Battegay Manuel, Fehr Jan (2013), Association of alcohol consumption and HIV surrogate markers in participants of the swiss HIV cohort study., in Journal of acquired immune deficiency syndromes (1999), 64(5), 472-8.
Temporal changes and regional differences in treatment uptake of hepatitis C therapy in EuroSIDA.
Grint D, Peters L, Schwarze-Zander C, Beniowski M, Pradier C, Battegay M, Jevtovic D, Soriano V, Lundgren J D, Rockstroh J K, Kirk O, Mocroft A, Mocroft A (2013), Temporal changes and regional differences in treatment uptake of hepatitis C therapy in EuroSIDA., in HIV medicine, 14(10), 614-23.
Associations between immune depression and cardiovascular events in HIV infection.
Sabin Caroline A, Ryom Lene, De Wit Stephane, Mocroft Amanda, Phillips Andrew N, Worm Signe W, Weber Rainer, D'Arminio Monforte Antonella, Reiss Peter, Kamara David, El-Sadr Wafaa, Pradier Christian, Dabis Francois, Law Matthew, Lundgren Jens, Lundgren Jens (2013), Associations between immune depression and cardiovascular events in HIV infection., in AIDS (London, England), 27(17), 2735-48.
Hepatitis B virus infection is associated with impaired immunological recovery during antiretroviral therapy in the Swiss HIV cohort study.
Wandeler Gilles, Gsponer Thomas, Bihl Florian, Bernasconi Enos, Cavassini Matthias, Kovari Helen, Schmid Patrick, Battegay Manuel, Calmy Alexandra, Egger Matthias, Furrer Hansjakob, Rauch Andri, Rauch Andri (2013), Hepatitis B virus infection is associated with impaired immunological recovery during antiretroviral therapy in the Swiss HIV cohort study., in The Journal of infectious diseases, 208(9), 1454-8.
The incidence of AIDS-defining illnesses at a current CD4 count ≥ 200 cells/μL in the post-combination antiretroviral therapy era.
Mocroft A, Furrer H J, Miro J M, Reiss P, Mussini C, Kirk O, Abgrall S, Ayayi S, Bartmeyer B, Braun D, Castagna A, d'Arminio Monforte A, Gazzard B, Gutierrez F, Hurtado I, Jansen K, Meyer L, Muñoz P, Obel N, Soler-Palacin P, Papadopoulos A, Raffi F, Ramos J T, Rockstroh J K, Salmon D, Torti C, Warszawski J, de Wit S, Zangerle R, Fabre-Colin C, Kjaer J, Chene G, Grarup J, Lundgren J D, Lundgren J D (2013), The incidence of AIDS-defining illnesses at a current CD4 count ≥ 200 cells/μL in the post-combination antiretroviral therapy era., in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 57(7), 1038-47.
A genome-to-genome analysis of associations between human genetic variation, HIV-1 sequence diversity, and viral control
Bartha István, Carlson Jonathan M, Brumme Chanson J, McLaren Paul J, Brumme Zabrina L, John Mina, Haas David W, Martinez-Picado Javier, Dalmau Judith, López-Galíndez Cecilio, Casado Concepción, Rauch Andri, Günthard Huldrych F, Bernasconi Enos, Vernazza Pietro, Klimkait Thomas, Yerly Sabine, O’Brien Stephen J, Listgarten Jennifer, Pfeifer Nico, Lippert Christoph, Fusi Nicolo, Kutalik Zoltán, Allen Todd M, et al. (2013), A genome-to-genome analysis of associations between human genetic variation, HIV-1 sequence diversity, and viral control, in eLife, 2, 1-16.
Non-AIDS defining cancers in the D:A:D Study--time trends and predictors of survival: a cohort study.
Worm Signe W, Bower Mark, Reiss Peter, Bonnet Fabrice, Law Matthew, Fätkenheuer Gerd, d'Arminio Monforte Antonella, Abrams Donald I, Grulich Andrew, Fontas Eric, Kirk Ole, Furrer Hansjakob, De Wit Stephane, Phillips Andrew, Lundgren Jens D, Sabin Caroline A, Sabin Caroline A (2013), Non-AIDS defining cancers in the D:A:D Study--time trends and predictors of survival: a cohort study., in BMC infectious diseases, 13, 471-471.
Advanced chronic kidney disease, end-stage renal disease and renal death among HIV-positive individuals in Europe.
Ryom L, Kirk O, Lundgren J D, Reiss P, Pedersen C, De Wit S, Buzunova S, Gasiorowski J, Gatell J M, Mocroft A, Mocroft A (2013), Advanced chronic kidney disease, end-stage renal disease and renal death among HIV-positive individuals in Europe., in HIV medicine, 14(8), 503-8.
Early and non-reversible decrease of CD161++/mucosal associated invariant T cells in HIV infection
Cosgrove Cormac, Ussher James E., Rauch Andri, Gärtner Kathleen, Kurioka Ayako, Hühn Michael H., Adelmann Krista, Kang Yu-Hoi, Fergusson Joannah R., Simmonds Peter, Goulder Philip, Hansen Ted H., Fox Julie, Günthard Huldrych F., Khanna Nina, Powrie Fiona, Steel Alan, Gazzard Brian, Phillips Rodney E., Frater John, Uhlig Holm, Klenerman Paul (2013), Early and non-reversible decrease of CD161++/mucosal associated invariant T cells in HIV infection, in Journal of Infection, 67(4), 342-343.
Origin of minority drug-resistant HIV-1 variants in primary HIV-1 infection.
Metzner Karin J, Scherrer Alexandra U, Preiswerk Benjamin, Joos Beda, von Wyl Viktor, Leemann Christine, Rieder Philip, Braun Dominique, Grube Christina, Kuster Herbert, Böni Jürg, Yerly Sabine, Klimkait Thomas, Aubert Vincent, Furrer Hansjakob, Battegay Manuel, Vernazza Pietro L, Cavassini Matthias, Calmy Alexandra, Bernasconi Enos, Weber Rainer, Günthard Huldrych F, Günthard Huldrych F (2013), Origin of minority drug-resistant HIV-1 variants in primary HIV-1 infection., in The Journal of infectious diseases, 208(7), 1102-12.
Natural history of HIV-control since seroconversion.
Madec Yoann, Boufassa Faroudy, Porter Kholoud, Prins Maria, Sabin Caroline, d'Arminio Monforte Antonella, Amornkul Pauli, Bartmeyer Barbara, Sannes Mette, Venet Alain, Lambotte Olivier, Meyer Laurence, Meyer Laurence (2013), Natural history of HIV-control since seroconversion., in AIDS (London, England), 27(15), 2451-60.
Risk Factors for Anal Cancer in Persons Infected With HIV: A Nested Case-Control Study in the Swiss HIV Cohort Study
Bertisch B., Franceschi S., Lise M., Vernazza P., Keiser O., Schoni-Affolter F., Bouchardy C., Dehler S., Levi F., Jundt G., Ess S., Pawlita M., Kovari H., Wandeler G., Calmy A., Cavassini M., Stockle M., Clifford G. (2013), Risk Factors for Anal Cancer in Persons Infected With HIV: A Nested Case-Control Study in the Swiss HIV Cohort Study, in American Journal of Epidemiology, 178(6), 877-884.
Missed opportunities among HIV-positive women to control viral replication during pregnancy and to have a vaginal delivery.
Aebi-Popp Karoline, Mulcahy Fiona, Glass Tracy R, Rudin Christoph, Martinez de Tejada Begona, Bertisch Barbara, Fehr Jan, Grawe Claudia, Scheibner Kathrin, Rickenbach Martin, Hoesli Irene, Thorne Claire, Thorne Claire, Thorne Claire (2013), Missed opportunities among HIV-positive women to control viral replication during pregnancy and to have a vaginal delivery., in Journal of acquired immune deficiency syndromes (1999), 64(1), 58-65.
Does hepatitis C viremia or genotype predict the risk of mortality in individuals co-infected with HIV?
Rockstroh Jürgen K, Peters Lars, Grint Daniel, Soriano Vincent, Reiss Peter, Monforte Antonella d'Arminio, Beniowski Marek, Losso Marcelo H, Kirk Ole, Kupfer Bernd, Mocroft Amanda, Mocroft Amanda (2013), Does hepatitis C viremia or genotype predict the risk of mortality in individuals co-infected with HIV?, in Journal of hepatology, 59(2), 213-20.
Association between ALT level and the rate of cardio/cerebrovascular events in HIV-positive individuals: the D: A: D study.
Sabin Caroline A, Ryom Lene, Kovari Helen, Kirk Ole, de Wit Stephane, Law Matthew, Reiss Peter, Dabis Francois, Pradier Christian, El-Sadr Wafaa, Monforte Antonella d'Arminio, Kamara David, Phillips Andrew N, Lundgren Jens D (2013), Association between ALT level and the rate of cardio/cerebrovascular events in HIV-positive individuals: the D: A: D study., in Journal of acquired immune deficiency syndromes (1999), 63(4), 456-63.
Contribution of genetic background, traditional risk factors, and HIV-related factors to coronary artery disease events in HIV-positive persons.
Rotger Margalida, Glass Tracy R, Junier Thomas, Lundgren Jens, Neaton James D, Poloni Estella S, van 't Wout Angélique B, Lubomirov Rubin, Colombo Sara, Martinez Raquel, Rauch Andri, Günthard Huldrych F, Neuhaus Jacqueline, Wentworth Deborah, van Manen Danielle, Gras Luuk A, Schuitemaker Hanneke, Albini Laura, Torti Carlo, Jacobson Lisa P, Li Xiuhong, Kingsley Lawrence A, Carli Federica, Guaraldi Giovanni, Ford Emily S, Sereti Irini, Hadigan Colleen, Martinez Esteban, Arnedo Mireia, Egaña-Gorroño Lander, Gatell Jose M, Law Matthew, Bendall Courtney, Petoumenos Kathy, Rockstroh Jürgen, Wasmuth Jan-Christian, Kabamba Kabeya, Delforge Marc, De Wit Stephane, Berger Florian, Mauss Stefan, de Paz Sierra Mariana, Losso Marcelo, Belloso Waldo H, Leyes Maria, Campins Antoni, Mondi Annalisa, De Luca Andrea, Bernardino Ignacio, Barriuso-Iglesias Mónica, Torrecilla-Rodriguez Ana, Gonzalez-Garcia Juan, Arribas José R, Fanti Iuri, Gel Silvia, Puig Jordi, Negredo Eugenia, Gutierrez Mar, Domingo Pere, Fischer Julia, Fätkenheuer Gerd, Alonso-Villaverde Carlos, Macken Alan, Woo James, McGinty Tara, Mallon Patrick, Mangili Alexandra, Skinner Sally, Wanke Christine A, Reiss Peter, Weber Rainer, Bucher Heiner C, Fellay Jacques, Telenti Amalio, Tarr Philip E, Tarr Philip E, Tarr Philip E, Tarr Philip E (2013), Contribution of genetic background, traditional risk factors, and HIV-related factors to coronary artery disease events in HIV-positive persons., in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 57(1), 112-21.
Multiplex liquid chromatography-tandem mass spectrometry assay for simultaneous therapeutic drug monitoring of ribavirin, boceprevir, and telaprevir.
Aouri Manel, Moradpour Darius, Cavassini Matthias, Mercier Thomas, Buclin Thierry, Csajka Chantal, Telenti Amalio, Rauch Andri, Decosterd Laurent A (2013), Multiplex liquid chromatography-tandem mass spectrometry assay for simultaneous therapeutic drug monitoring of ribavirin, boceprevir, and telaprevir., in Antimicrobial agents and chemotherapy, 57(7), 3147-58.
Stability of hepatitis C virus (HCV) RNA levels among interferon-naïve HIV/HCV-coinfected individuals treated with combination antiretroviral therapy.
Grint D, Peters L, Reekie J, Soriano V, Kirk O, Knysz B, Suetnov O, Lazzarin A, Ledergerber B, Rockstroh J K, Mocroft A, Mocroft A (2013), Stability of hepatitis C virus (HCV) RNA levels among interferon-naïve HIV/HCV-coinfected individuals treated with combination antiretroviral therapy., in HIV medicine, 14(6), 370-8.
Influence of geographical origin and ethnicity on mortality in patients on antiretroviral therapy in Canada, Europe, and the United States.
Antiretroviral Therapy Cohort Collaboration (ART-CC) (2013), Influence of geographical origin and ethnicity on mortality in patients on antiretroviral therapy in Canada, Europe, and the United States., in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 56(12), 1800-9.
Insurability of HIV-positive people treated with antiretroviral therapy in Europe: collaborative analysis of HIV cohort studies.
Kaulich-Bartz Josee, Dam Wayne, May Margaret T, Lederberger Bruno, Widmer Urs, Phillips Andrew N, Grabar Sophie, Mocroft Amanda, Vilaro Josep, van Sighem Ard, Moreno Santiago, Dabis François, Monforte Antonella D'Arminio, Teira Ramon, Ingle Suzanne M, Sterne Jonathan A C, Sterne Jonathan A C (2013), Insurability of HIV-positive people treated with antiretroviral therapy in Europe: collaborative analysis of HIV cohort studies., in AIDS (London, England), 27(10), 1641-55.
Hyaluronic Acid Levels Predict Risk of Hepatic Encephalopathy and Liver-Related Death in HIV/Viral Hepatitis Coinfected Patients
Peters Lars, Mocroft Amanda, Soriano Vincent, Rockstroh Jürgen, Rauch Andri, Karlsson Anders, Knysz Brygida, Pradier Christian, Zilmer Kai, Lundgren Jens D. (2013), Hyaluronic Acid Levels Predict Risk of Hepatic Encephalopathy and Liver-Related Death in HIV/Viral Hepatitis Coinfected Patients, in PLoS ONE, 8(5), e64283-e64283.
A genome-wide association study of resistance to HIV infection in highly exposed uninfected individuals with hemophilia A.
Lane Jérôme, McLaren Paul J, Dorrell Lucy, Shianna Kevin V, Stemke Amanda, Pelak Kimberly, Moore Stephen, Oldenburg Johannes, Alvarez-Roman Maria Teresa, Angelillo-Scherrer Anne, Boehlen Francoise, Bolton-Maggs Paula H B, Brand Brigit, Brown Deborah, Chiang Elaine, Cid-Haro Ana Rosa, Clotet Bonaventura, Collins Peter, Colombo Sara, Dalmau Judith, Fogarty Patrick, Giangrande Paul, Gringeri Alessandro, Iyer Rathi, Katsarou Olga, Kempton Christine, Kuriakose Philip, Lin Judith, Makris Mike, Manco-Johnson Marilyn, Tsakiris Dimitrios A, Martinez-Picado Javier, Mauser-Bunschoten Evelien, Neff Anne, Oka Shinichi, Oyesiku Lara, Parra Rafael, Peter-Salonen Kristiina, Powell Jerry, Recht Michael, Shapiro Amy, Stine Kimo, Talks Katherine, Telenti Amalio, Wilde Jonathan, Yee Thynn Thynn, Wolinsky Steven M, Martinson Jeremy, Hussain Shehnaz K, Bream Jay H, Jacobson Lisa P, Carrington Mary, Goedert James J, Haynes Barton F, McMichael Andrew J, Goldstein David B, Fellay Jacques, Fellay Jacques (2013), A genome-wide association study of resistance to HIV infection in highly exposed uninfected individuals with hemophilia A., in Human molecular genetics, 22(9), 1903-10.
Adherence to antiretroviral treatment decreases during postpartum compared to pregnancy: a longitudinal electronic monitoring study.
Gertsch Aurélie, Michel Odile, Locatelli Isabella, Bugnon Olivier, Rickenbach Martin, Cavassini Matthias, Schneider Marie-Paule (2013), Adherence to antiretroviral treatment decreases during postpartum compared to pregnancy: a longitudinal electronic monitoring study., in AIDS patient care and STDs, 27(4), 208-10.
Association between antiretroviral exposure and renal impairment among HIV-positive persons with normal baseline renal function: the D:A:D study.
Ryom Lene, Mocroft Amanda, Kirk Ole, Worm Signe W, Kamara David A, Reiss Peter, Ross Michael, Fux Christoph A, Morlat Philippe, Moranne Olivier, Smith Colette, Lundgren Jens D, Lundgren Jens D (2013), Association between antiretroviral exposure and renal impairment among HIV-positive persons with normal baseline renal function: the D:A:D study., in The Journal of infectious diseases, 207(9), 1359-69.
Decreasing mortality and changing patterns of causes of death in the Swiss HIV Cohort Study.
Weber R, Ruppik M, Rickenbach M, Spoerri A, Furrer H, Battegay M, Cavassini M, Calmy A, Bernasconi E, Schmid P, Flepp M, Kowalska J, Ledergerber B, Ledergerber B (2013), Decreasing mortality and changing patterns of causes of death in the Swiss HIV Cohort Study., in HIV medicine, 14(4), 195-207.
Effect of HCV infection on cause-specific mortality after HIV seroconversion, before and after 1997.
van der Helm Jannie, Geskus Ronald, Sabin Caroline, Meyer Laurence, Del Amo Julia, Chêne Geneviève, Dorrucci Maria, Muga Roberto, Porter Kholoud, Prins Maria, Prins Maria (2013), Effect of HCV infection on cause-specific mortality after HIV seroconversion, before and after 1997., in Gastroenterology, 144(4), 751-752.
Expansion of interferon-γ-secreting HIV-specific T cells during successful antiretroviral therapy.
Gasser O, Brander C, Wolbers M, Brown N V, Rauch A, Günthard H F, Battegay M, Hess C, Hess C (2013), Expansion of interferon-γ-secreting HIV-specific T cells during successful antiretroviral therapy., in HIV medicine, 14(4), 241-6.
Higher rates of AIDS during the first year of antiretroviral therapy among migrantsthe importance of tuberculosis
Shepherd BE (2013), Higher rates of AIDS during the first year of antiretroviral therapy among migrantsthe importance of tuberculosis, in AIDS, 27(8), 1321-1329.
Influence of HLA-C expression level on HIV control.
Apps Richard, Qi Ying, Carlson Jonathan M, Chen Haoyan, Gao Xiaojiang, Thomas Rasmi, Yuki Yuko, Del Prete Greg Q, Goulder Philip, Brumme Zabrina L, Brumme Chanson J, John Mina, Mallal Simon, Nelson George, Bosch Ronald, Heckerman David, Stein Judy L, Soderberg Kelly A, Moody M Anthony, Denny Thomas N, Zeng Xue, Fang Jingyuan, Moffett Ashley, Lifson Jeffrey D, Goedert James J, Buchbinder Susan, Kirk Gregory D, Fellay Jacques, McLaren Paul, Deeks Steven G, Pereyra Florencia, Walker Bruce, Michael Nelson L, Weintrob Amy, Wolinsky Steven, Liao Wilson, Carrington Mary (2013), Influence of HLA-C expression level on HIV control., in Science (New York, N.Y.), 340(6128), 87-91.
Rate of CD4 decline and HIV-RNA change following HIV seroconversion in men who have sex with men: a comparison between the Beijing PRIMO and CASCADE cohorts.
Huang Xiaojie, Lodi Sara, Fox Zoe, Li Wei, Phillips Andrew, Porter Kholoud, Lutsar Irja, Kelleher Anthony, Li Ning, Xu Xiaoning, Wu Hao, Johnson Anne M, Johnson Anne M, Johnson Anne M (2013), Rate of CD4 decline and HIV-RNA change following HIV seroconversion in men who have sex with men: a comparison between the Beijing PRIMO and CASCADE cohorts., in Journal of acquired immune deficiency syndromes (1999), 62(4), 441-6.
Risk of cardiovascular events and blood pressure control in hypertensive HIV-infected patients: Swiss HIV Cohort Study (SHCS).
Nüesch Reto, Wang Qing, Elzi Luigia, Bernasconi Enos, Weber Rainer, Cavassini Matthias, Vernazza Pietro, Thurnheer Maria C, Calmy Alexandra, Battegay Manuel, Bucher Heiner C, Bucher Heiner C (2013), Risk of cardiovascular events and blood pressure control in hypertensive HIV-infected patients: Swiss HIV Cohort Study (SHCS)., in Journal of acquired immune deficiency syndromes (1999), 62(4), 396-404.
Antiretroviral drug-related liver mortality among HIV-positive persons in the absence of hepatitis B or C virus coinfection: the data collection on adverse events of anti-HIV drugs study.
Kovari Helen, Sabin Caroline A, Ledergerber Bruno, Ryom Lene, Worm Signe W, Smith Colette, Phillips Andrew, Reiss Peter, Fontas Eric, Petoumenos Kathy, De Wit Stéphane, Morlat Philippe, Lundgren Jens D, Weber Rainer (2013), Antiretroviral drug-related liver mortality among HIV-positive persons in the absence of hepatitis B or C virus coinfection: the data collection on adverse events of anti-HIV drugs study., in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 56(6), 870-9.
Impact of HIV-1 subtype on CD4 count at HIV seroconversion, rate of decline, and viral load set point in European seroconverter cohorts.
Touloumi Giota, Pantazis Nikos, Pillay Deenan, Paraskevis Dimitrios, Chaix Marie-Laure, Bucher Heiner C, Kücherer Claudia, Zangerle Robert, Kran Anne-Marte Bakken, Porter Kholoud, Porter Kholoud (2013), Impact of HIV-1 subtype on CD4 count at HIV seroconversion, rate of decline, and viral load set point in European seroconverter cohorts., in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 56(6), 888-97.
Risk of tuberculosis following HIV seroconversion in high-income countries.
Lodi Sara, del Amo Julia, d'Arminio Monforte Antonella, Abgrall Sophie, Sabin Caroline, Morrison Charles, Furrer Hansjakob, Muga Roberto, Porter Kholoud, Girardi Enrico, Girardi Enrico (2013), Risk of tuberculosis following HIV seroconversion in high-income countries., in Thorax, 68(3), 207-13.
CD4 cell count and viral load-specific rates of AIDS, non-AIDS and deaths according to current antiretroviral use.
Mocroft Amanda, Phillips Andrew N, Gatell Jose, Horban Andrej, Ledergerber Bruno, Zilmer Kai, Jevtovic Djordje, Maltez Fernando, Podlekareva Daria, Lundgren Jens D, Lundgren Jens D (2013), CD4 cell count and viral load-specific rates of AIDS, non-AIDS and deaths according to current antiretroviral use., in AIDS (London, England), 27(6), 907-18.
Use of combination neonatal prophylaxis for the prevention of mother-to-child transmission of HIV infection in European high-risk infants.
Chiappini Elena, Galli Luisa, Giaquinto Carlo, Ene Luminita, Goetghebuer Tessa, Judd Ali, Lisi Catiuscia, Malyuta Ruslan, Noguera-Julian Antoni, Ramos Jose Tomas, Rojo-Conejo Pablo, Rudin Christoph, Tookey Pat, de Martino Maurizio, Thorne Claire, Thorne Claire (2013), Use of combination neonatal prophylaxis for the prevention of mother-to-child transmission of HIV infection in European high-risk infants., in AIDS (London, England), 27(6), 991-1000.
Durability of first ART regimen and risk factors for modification, interruption or death in HIV-positive patients starting ART in Europe and North America 2002-2009.
Abgrall Sophie, Ingle Suzanne M, May Margaret T, Costagliola Dominque, Mercie Patrick, Cavassini Matthias, Reekie Joanne, Samji Hasina, Gill M John, Crane Heidi M, Tate Jan, Sterling Timothy R, Antinori Andrea, Reiss Peter, Saag Michael S, Mugavero Michael J, Phillips Andrew, Manzardo Christian, Wasmuth Jan-Christian, Stephan Christoph, Guest Jodie L, Gomez Sirvent Juan Luis, Sterne Jonathan A C, Sterne Jonathan A C (2013), Durability of first ART regimen and risk factors for modification, interruption or death in HIV-positive patients starting ART in Europe and North America 2002-2009., in AIDS (London, England), 27(5), 803-13.
Health care index score and risk of death following tuberculosis diagnosis in HIV-positive patients.
Podlekareva D N, Grint D, Post F A, Mocroft A, Panteleev A M, Miller R F, Miro J M, Bruyand M, Furrer H, Riekstina V, Girardi E, Losso M H, Caylá J A, Malashenkov E A, Obel N, Skrahina A M, Lundgren J D, Kirk O, Kirk O (2013), Health care index score and risk of death following tuberculosis diagnosis in HIV-positive patients., in The international journal of tuberculosis and lung disease : the official journal of the Internation, 17(2), 198-206.
Predictors of CD4(+) T-cell counts of HIV type 1-infected persons after virologic failure of all 3 original antiretroviral drug classes.
Pursuing Later Treatment Option II (PLATO II) Project Team of the Collaboration of Observational HIV Epidemiological Research Europe (COHERE), Costagliola Dominique, Ledergerber Bruno, Torti Carlo, van Sighem Ard, Podzamczer Daniel, Mocroft Amanda, Dorrucci Maria, Masquelier Bernard, de Luca Andrea, Jansen Klaus, De Wit Stephane, Obel Niels, Fätkenheuer Gerd, Touloumi Giota, Mussini Cristina, Castagna Antonella, Stephan Cristoph, García Federico, Zangerle Robert, Duval Xavier, Perez-Hoyos Santiago, Meyer Laurence, Ghosn Jade, Fabre-Colin Céline, Kjaer Jesper, Chêne Genevieve, Grarup Jesper, Phillips Andrew, Lodwick Rebecca, Torti Carlo, Dorrucci Maria, Günthard Huldrych F, Michalik Claudia, Chrysos George, Castagna Antonella (2013), Predictors of CD4(+) T-cell counts of HIV type 1-infected persons after virologic failure of all 3 original antiretroviral drug classes., in The Journal of infectious diseases, 207(5), 759-67.
An internationally generalizable risk index for mortality after one year of antiretroviral therapy.
Tate Janet P, Justice Amy C, Hughes Michael D, Bonnet Fabrice, Reiss Peter, Mocroft Amanda, Nattermann Jacob, Lampe Fiona C, Bucher Heiner C, Sterling Timothy R, Crane Heidi M, Kitahata Mari M, May Margaret, Sterne Jonathan A C (2013), An internationally generalizable risk index for mortality after one year of antiretroviral therapy., in AIDS (London, England), 27(4), 563-72.
Outcomes after reinitiating antiretroviral therapy in children randomized to planned treatment interruptions.
Bunupuradah Torsak, Duong Trinh, Compagnucci Alexandra, McMaster Paddy, Bernardi Stefania, Kanjanavanit Suparat, Rampon Osvalda, Faye Albert, Saïdi Yacine, Riault Yoann, De Rossi Anita, Klein Nigel, Ananworanich Jintanat, Gibb Diana, Gibb Diana (2013), Outcomes after reinitiating antiretroviral therapy in children randomized to planned treatment interruptions., in AIDS (London, England), 27(4), 579-89.
Early and nonreversible decrease of CD161++ /MAIT cells in HIV infection.
Cosgrove Cormac, Ussher James E, Rauch Andri, Gärtner Kathleen, Kurioka Ayako, Hühn Michael H, Adelmann Krista, Kang Yu-Hoi, Fergusson Joannah R, Simmonds Peter, Goulder Philip, Hansen Ted H, Fox Julie, Günthard Huldrych F, Khanna Nina, Powrie Fiona, Steel Alan, Gazzard Brian, Phillips Rodney E, Frater John, Uhlig Holm, Klenerman Paul (2013), Early and nonreversible decrease of CD161++ /MAIT cells in HIV infection., in Blood, 121(6), 951-61.
Rivastigmine for HIV-associated neurocognitive disorders: a randomized crossover pilot study.
Simioni Samanta, Cavassini Matthias, Annoni Jean-Marie, Métral Mélanie, Iglesias Katia, Rimbault Abraham Aline, Jilek Samantha, Calmy Alexandra, Müller Hubertus, Fayet-Mello Aurélie, Giacobini Ezio, Hirschel Bernard, Du Pasquier Renaud A (2013), Rivastigmine for HIV-associated neurocognitive disorders: a randomized crossover pilot study., in Neurology, 80(6), 553-60.
Impact of recommendation updates in well-controlled patients on nonrecommended antiretroviral therapies: the Swiss HIV cohort study.
Boillat-Blanco Noémie, Darling Katharine E A, Taffe Patrick, Osih Regina, Strahm Carol, Adami Maddalena, Elzi Luigia, Daou Samira, Fehr Jan, Wandeler Gilles, Cavassini Matthias (2013), Impact of recommendation updates in well-controlled patients on nonrecommended antiretroviral therapies: the Swiss HIV cohort study., in Journal of acquired immune deficiency syndromes (1999), 62(2), 180-9.
How effectively can HIV phylogenies be used to measure heritability?
Shirreff George, Alizon Samuel, Cori Anne, Günthard Huldrych F, Laeyendecker Oliver, van Sighem Ard, Bezemer Daniela, Fraser Christophe (2013), How effectively can HIV phylogenies be used to measure heritability?, in Evolution, medicine, and public health, 2013(1), 209-24.
Pharmacogenetics-based population pharmacokinetic analysis of etravirine in HIV-1 infected individuals.
Lubomirov Rubin, Arab-Alameddine Mona, Rotger Margalida, Fayet-Mello Aurélie, Martinez Raquel, Guidi Monia, di Iulio Julia, Cavassini Matthias, Günthard Huldrych F, Furrer Hansjakob, Marzolini Catia, Bernasconi Enos, Calmy Alexandra, Buclin Thierry, Decosterd Laurent A, Csajka Chantal, Telenti Amalio, Telenti Amalio (2013), Pharmacogenetics-based population pharmacokinetic analysis of etravirine in HIV-1 infected individuals., in Pharmacogenetics and genomics, 23(1), 9-18.
Atazanavir is not associated with an increased risk of cardio- or cerebrovascular disease events.
Monforte Antonella d'Arminio, Reiss Peter, Ryom Lene, El-Sadr Wafaa, Dabis Francois, De Wit Stephane, Worm Signe W, Law Mathew G, Weber Rainer, Kirk Ole, Pradier Christian, Phillips Andrew N, Lundgren Jens D, Sabin Caroline A (2013), Atazanavir is not associated with an increased risk of cardio- or cerebrovascular disease events., in AIDS (London, England), 27(3), 407-15.
Marked increase of the astrocytic marker S100B in the cerebrospinal fluid of HIV-infected patients on LPV/r-monotherapy.
Du Pasquier Renaud A, Jilek Samantha, Kalubi Malela, Yerly Sabine, Fux Christoph A, Gutmann Christine, Cusini Alexia, Günthard Huldrych F, Cavassini Matthias, Vernazza Pietro L, Vernazza Pietro L (2013), Marked increase of the astrocytic marker S100B in the cerebrospinal fluid of HIV-infected patients on LPV/r-monotherapy., in AIDS (London, England), 27(2), 203-10.
Higher CNS penetration-effectiveness of long-term combination antiretroviral therapy is associated with better HIV-1 viral suppression in cerebrospinal fluid.
Cusini Alexia, Vernazza Pietro L, Yerly Sabine, Decosterd Laurent A, Ledergerber Bruno, Fux Christoph A, Rohrbach Janine, Widmer Nicolas, Hirschel Bernhard, Gaudenz Roman, Cavassini Matthias, Klimkait Thomas, Zenger Franziska, Gutmann Chistine, Opravil Milos, Günthard Huldyrich F, Günthard Huldyrich F (2013), Higher CNS penetration-effectiveness of long-term combination antiretroviral therapy is associated with better HIV-1 viral suppression in cerebrospinal fluid., in Journal of acquired immune deficiency syndromes (1999), 62(1), 28-35.
CD4 cell count and the risk of AIDS or death in HIV-Infected adults on combination antiretroviral therapy with a suppressed viral load: a longitudinal cohort study from COHERE.
Opportunistic Infections Project Team of the Collaboration of Observational HIV Epidemiological Research in Europe (COHERE) in EuroCoord, Young Jim, Psichogiou Mina, Meyer Laurence, Ayayi Sylvie, Grabar Sophie, Raffi Francois, Reiss Peter, Gazzard Brian, Sharland Mike, Gutierrez Félix, Obel Niels, Kirk Ole, Miro José M, Furrer Hansjakob, Castagna Antonella, De Wit Stéphane, Muñoz Josefa, Kjaer Jesper, Grarup Jesper, Chêne Geneviève, Bucher Heiner (2012), CD4 cell count and the risk of AIDS or death in HIV-Infected adults on combination antiretroviral therapy with a suppressed viral load: a longitudinal cohort study from COHERE., in PLoS medicine, 9(3), 1001194-1001194.
Heterogeneity in outcomes of treated HIV-positive patients in Europe and North America: relation with patient and cohort characteristics.
May Margaret T, Hogg Robert S, Justice Amy C, Shepherd Bryan E, Costagliola Dominique, Ledergerber Bruno, Thiébaut Rodolphe, Gill M John, Kirk Ole, van Sighem Ard, Saag Michael S, Navarro Gemma, Sobrino-Vegas Paz, Lampe Fiona, Ingle Suzanne, Guest Jodie L, Crane Heidi M, D'Arminio Monforte Antonella, Vehreschild Jörg J, Sterne Jonathan A C, Sterne Jonathan A C (2012), Heterogeneity in outcomes of treated HIV-positive patients in Europe and North America: relation with patient and cohort characteristics., in International journal of epidemiology, 41(6), 1807-20.
Higher memory responses in HIV-infected and kidney transplanted patients than in healthy subjects following priming with the pandemic vaccine.
Siegrist Claire-Anne, van Delden Christian, Bel Michael, Combescure Christophe, Delhumeau Cécile, Cavassini Matthias, Clerc Olivier, Meier Sara, Hadaya Karine, Soccal Paola M, Yerly Sabine, Kaiser Laurent, Hirschel Bernard, Calmy Alexandra, Calmy Alexandra, Calmy Alexandra (2012), Higher memory responses in HIV-infected and kidney transplanted patients than in healthy subjects following priming with the pandemic vaccine., in PloS one, 7(7), 40428-40428.
Inferring epidemic contact structure from phylogenetic trees.
Leventhal Gabriel E, Kouyos Roger, Stadler Tanja, Wyl Viktor von, Yerly Sabine, Böni Jürg, Cellerai Cristina, Klimkait Thomas, Günthard Huldrych F, Bonhoeffer Sebastian (2012), Inferring epidemic contact structure from phylogenetic trees., in PLoS computational biology, 8(3), 1002413-1002413.
Inflammation, coagulation and cardiovascular disease in HIV-infected individuals.
Duprez Daniel A, Neuhaus Jacqueline, Kuller Lewis H, Tracy Russell, Belloso Waldo, De Wit Stephane, Drummond Fraser, Lane H Clifford, Ledergerber Bruno, Lundgren Jens, Nixon Daniel, Paton Nicholas I, Prineas Ronald J, Neaton James D, Neaton James D (2012), Inflammation, coagulation and cardiovascular disease in HIV-infected individuals., in PloS one, 7(9), 44454-44454.
Long-lasting protection of activity of nucleoside reverse transcriptase inhibitors and protease inhibitors (PIs) by boosted PI containing regimens.
Scherrer Alexandra U, Böni Jürg, Yerly Sabine, Klimkait Thomas, Aubert Vincent, Furrer Hansjakob, Calmy Alexandra, Cavassini Matthias, Elzi Luigia, Vernazza Pietro L, Bernasconi Enos, Ledergerber Bruno, Günthard Huldrych F, Günthard Huldrych F (2012), Long-lasting protection of activity of nucleoside reverse transcriptase inhibitors and protease inhibitors (PIs) by boosted PI containing regimens., in PloS one, 7(11), 50307-50307.
Minor protease inhibitor mutations at baseline do not increase the risk for a virological failure in HIV-1 subtype B infected patients.
Scherrer Alexandra U, Ledergerber Bruno, von Wyl Viktor, Böni Jürg, Yerly Sabine, Klimkait Thomas, Cellerai Cristina, Furrer Hansjakob, Calmy Alexandra, Cavassini Matthias, Elzi Luigia, Vernazza Pietro L, Bernasconi Enos, Günthard Huldrych F, Günthard Huldrych F (2012), Minor protease inhibitor mutations at baseline do not increase the risk for a virological failure in HIV-1 subtype B infected patients., in PloS one, 7(6), 37983-37983.
Resurgence of HIV infection among men who have sex with men in Switzerland: mathematical modelling study.
van Sighem Ard, Vidondo Beatriz, Glass Tracy R, Bucher Heiner C, Vernazza Pietro, Gebhardt Martin, de Wolf Frank, Derendinger Steven, Jeannin André, Bezemer Daniela, Fraser Christophe, Low Nicola, Low Nicola (2012), Resurgence of HIV infection among men who have sex with men in Switzerland: mathematical modelling study., in PloS one, 7(9), 44819-44819.
Tuberculosis in HIV-negative and HIV-infected patients in a low-incidence country: clinical characteristics and treatment outcomes.
Fenner Lukas, Gagneux Sebastien, Janssens Jean-Paul, Fehr Jan, Cavassini Matthias, Hoffmann Matthias, Bernasconi Enos, Schrenzel Jacques, Bodmer Thomas, Böttger Erik C, Helbling Peter, Egger Matthias, Egger Matthias (2012), Tuberculosis in HIV-negative and HIV-infected patients in a low-incidence country: clinical characteristics and treatment outcomes., in PloS one, 7(3), 34186-34186.
Whole genome deep sequencing of HIV-1 reveals the impact of early minor variants upon immune recognition during acute infection.
Henn Matthew R, Boutwell Christian L, Charlebois Patrick, Lennon Niall J, Power Karen A, Macalalad Alexander R, Berlin Aaron M, Malboeuf Christine M, Ryan Elizabeth M, Gnerre Sante, Zody Michael C, Erlich Rachel L, Green Lisa M, Berical Andrew, Wang Yaoyu, Casali Monica, Streeck Hendrik, Bloom Allyson K, Dudek Tim, Tully Damien, Newman Ruchi, Axten Karen L, Gladden Adrianne D, Battis Laura, Kemper Michael, Zeng Qiandong, Shea Terrance P, Gujja Sharvari, Zedlack Carmen, Gasser Olivier, Brander Christian, Hess Christoph, Günthard Huldrych F, Brumme Zabrina L, Brumme Chanson J, Bazner Suzane, Rychert Jenna, Tinsley Jake P, Mayer Ken H, Rosenberg Eric, Pereyra Florencia, Levin Joshua Z, Young Sarah K, Jessen Heiko, Altfeld Marcus, Birren Bruce W, Walker Bruce D, Allen Todd M (2012), Whole genome deep sequencing of HIV-1 reveals the impact of early minor variants upon immune recognition during acute infection., in PLoS pathogens, 8(3), 1002529-1002529.
Determinants of sustained viral suppression in HIV-infected patients with self-reported poor adherence to antiretroviral therapy.
Glass Tracy R, Rotger Margalida, Telenti Amalio, Decosterd Laurent, Csajka Chantal, Bucher Heiner C, Günthard Huldrych F, Rickenbach Martin, Nicca Dunja, Hirschel Bernard, Bernasconi Enos, Wandeler Gilles, Battegay Manuel, Marzolini Catia, Marzolini Catia (2012), Determinants of sustained viral suppression in HIV-infected patients with self-reported poor adherence to antiretroviral therapy., in PloS one, 7(1), 29186-29186.
Differences in HIV natural history among African and non-African seroconverters in Europe and seroconverters in sub-Saharan Africa.
Pantazis Nikos, Morrison Charles, Amornkul Pauli N, Lewden Charlotte, Salata Robert A, Minga Albert, Chipato Tsungai, Jaffe Harold, Lakhi Shabir, Karita Etienne, Porter Kholoud, Meyer Laurence, Touloumi Giota, Touloumi Giota (2012), Differences in HIV natural history among African and non-African seroconverters in Europe and seroconverters in sub-Saharan Africa., in PloS one, 7(3), 32369-32369.
Effect of hepatitis C treatment on CD4+ T-cell counts and the risk of death in HIV-HCV-coinfected patients: the COHERE collaboration.
HCV working group of the Collaboration of Observational HIV Epidemiological Research in Europe (COHERE) in EuroCoord (2012), Effect of hepatitis C treatment on CD4+ T-cell counts and the risk of death in HIV-HCV-coinfected patients: the COHERE collaboration., in Antiviral therapy, 17(8), 1541-50.
Genetic diversity of EBV-encoded LMP1 in the Swiss HIV Cohort Study and implication for NF-Κb activation.
Zuercher Emilie, Butticaz Christophe, Wyniger Josiane, Martinez Raquel, Battegay Manuel, Boffi El Amari Emmanuelle, Dang Thanh, Egger Jean-François, Fehr Jan, Mueller-Garamvögyi Esther, Parini Andrea, Schaefer Stephan C, Schoeni-Affolter Franziska, Thurnheer Christine, Tinguely Marianne, Telenti Amalio, Rothenberger Sylvia, Rothenberger Sylvia (2012), Genetic diversity of EBV-encoded LMP1 in the Swiss HIV Cohort Study and implication for NF-Κb activation., in PloS one, 7(2), 32168-32168.
Regional differences in AIDS and non-AIDS related mortality in HIV-positive individuals across Europe and Argentina: the EuroSIDA study.
Reekie Joanne, Kowalska Justyna D, Karpov Igor, Rockstroh Jurgen, Karlsson Anders, Rakhmanova Aza, Horban Andrzej, Kirk Ole, Lundgren Jens D, Mocroft Amanda, Mocroft Amanda (2012), Regional differences in AIDS and non-AIDS related mortality in HIV-positive individuals across Europe and Argentina: the EuroSIDA study., in PloS one, 7(7), 41673-41673.
The clinical benefits of antiretroviral therapy in severely immunocompromised HIV-1-infected patients with and without complete viral suppression.
Mocroft Amanda, Bannister Wendy P, Kirk Ole, Kowalska Justyna D, Reiss Peter, D'Arminio-Monforte Antonella, Gatell Jose, Fisher Martin, Trocha Hanna, Rakhmanova Aza, Lundgren Jens D, Lundgren Jens D (2012), The clinical benefits of antiretroviral therapy in severely immunocompromised HIV-1-infected patients with and without complete viral suppression., in Antiviral therapy, 17(7), 1291-300.
The XTrack system: application and advantage.
Klimkait Thomas (2012), The XTrack system: application and advantage., in Intervirology, 55(2), 118-22.
Time to virological failure, treatment change and interruption for individuals treated within 12 months of HIV seroconversion and in chronic infection.
Zugna Daniela, Geskus Ronald B, De Stavola Bianca, Rosinska Magdalena, Bartmeyer Barbara, Boufassa Faroudy, Chaix Marie-Laure, Babiker Abdel, Porter Kholoud, Porter Kholoud (2012), Time to virological failure, treatment change and interruption for individuals treated within 12 months of HIV seroconversion and in chronic infection., in Antiviral therapy, 17(6), 1039-48.
Causality, mediation and time: a dynamic viewpoint.
Aalen Odd O, Røysland Kjetil, Gran Jon Michael, Ledergerber Bruno (2012), Causality, mediation and time: a dynamic viewpoint., in Journal of the Royal Statistical Society. Series A, (Statistics in Society), 175(4), 831-861.
HLA-Bw4 identifies a population of HIV-infected patients with an increased capacity to control viral replication after structured treatment interruption.
Stern M, Czaja K, Rauch A, Rickenbach M, Günthard H F, Battegay M, Fellay J, Hirschel B, Hess C, Hess C (2012), HLA-Bw4 identifies a population of HIV-infected patients with an increased capacity to control viral replication after structured treatment interruption., in HIV medicine, 13(10), 589-95.
Increased macrophage migration inhibitory factor (MIF) plasma levels in acute HIV-1 infection.
Delaloye Julie, De Bruin Irma J A, Darling Katharine E A, Reymond Marlies Knaup, Sweep Fred C G J, Roger Thierry, Calandra Thierry, Cavassini Matthias (2012), Increased macrophage migration inhibitory factor (MIF) plasma levels in acute HIV-1 infection., in Cytokine, 60(2), 338-40.
Determinants of hepatitis A vaccine immunity in a cohort of human immunodeficiency virus-infected children living in Switzerland.
Crisinel Pierre Alex, Posfay-Barbe Klara Maria, Aebi Christoph, Cheseaux Jean-Jacques, Kahlert Christian, Rudin Christoph, Nadal David, Siegrist Claire-Anne, Siegrist Claire-Anne (2012), Determinants of hepatitis A vaccine immunity in a cohort of human immunodeficiency virus-infected children living in Switzerland., in Clinical and vaccine immunology : CVI, 19(11), 1751-7.
Hepatitis C virus infections in the Swiss HIV Cohort Study: a rapidly evolving epidemic.
Wandeler Gilles, Gsponer Thomas, Bregenzer Andrea, Günthard Huldrych F, Clerc Olivier, Calmy Alexandra, Stöckle Marcel, Bernasconi Enos, Furrer Hansjakob, Rauch Andri, Rauch Andri (2012), Hepatitis C virus infections in the Swiss HIV Cohort Study: a rapidly evolving epidemic., in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 55(10), 1408-16.
Patterns of adherence to raltegravir-based regimens and the risk of virological failure among HIV-infected patients: the RALTECAPS cohort study.
Gras Guillaume, Schneider Marie-Paule, Cavassini Matthias, Lucht Frédéric, Loilier Magalie, Verdon Renaud, Bernard Louis, Parienti Jean-Jacques (2012), Patterns of adherence to raltegravir-based regimens and the risk of virological failure among HIV-infected patients: the RALTECAPS cohort study., in Journal of acquired immune deficiency syndromes (1999), 61(3), 265-9.
Impact of highly active antiretroviral therapy on the molecular epidemiology of newly diagnosed HIV infections.
Ambrosioni Juan, Junier Thomas, Delhumeau Cécile, Calmy Alexandra, Hirschel Bernard, Zdobnov Evgeny, Kaiser Laurent, Yerly Sabine, Yerly Sabine (2012), Impact of highly active antiretroviral therapy on the molecular epidemiology of newly diagnosed HIV infections., in AIDS (London, England), 26(16), 2079-86.
Predicting the short-term risk of diabetes in HIV-positive patients: the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study.
Petoumenos Kathy, Worm Signe W, Fontas Eric, Weber Rainer, De Wit Stephane, Bruyand Mathias, Reiss Peter, El-Sadr Wafaa, Monforte Antonella D'Arminio, Friis-Møller Nina, Lundgren Jens D, Law Matthew G, Law Matthew G (2012), Predicting the short-term risk of diabetes in HIV-positive patients: the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study., in Journal of the International AIDS Society, 15(2), 17426-17426.
Benchmarking HIV health care: from individual patient care to health care evaluation. An example from the EuroSIDA study.
Podlekareva Daria N, Reekie Joanne, Mocroft Amanda, Losso Marcelo, Rakhmanova Aza G, Bakowska Elzbieta, Karpov Igor A, Lazarus Jeffrey V, Gatell Jose, Lundgren Jens D, Kirk Ole, Kirk Ole (2012), Benchmarking HIV health care: from individual patient care to health care evaluation. An example from the EuroSIDA study., in BMC infectious diseases, 12, 229-229.
Choice of Initial Combination Antiretroviral Therapy in Individuals With HIV Infection: Determinants and Outcomes.
Elzi Luigia, Erb Stefan, Furrer Hansjakob, Ledergerber Bruno, Cavassini Matthias, Hirschel Bernard, Vernazza Pietro, Bernasconi Enos, Weber Rainer, Battegay Manuel, Battegay Manuel (2012), Choice of Initial Combination Antiretroviral Therapy in Individuals With HIV Infection: Determinants and Outcomes., in Archives of internal medicine, 172(17), 1313-21.
Immune response to hepatitis B vaccination in HIV-positive adults with isolated antibodies to HBV core antigen.
Kaech Chloe, Pache Isabelle, Bürgisser Philippe, Elzi Luigia, Darling Katharine E A, Cavassini Matthias (2012), Immune response to hepatitis B vaccination in HIV-positive adults with isolated antibodies to HBV core antigen., in The Journal of infection, 65(2), 157-64.
Outcome of smoking cessation counselling of HIV-positive persons by HIV care physicians.
Huber M, Ledergerber B, Sauter R, Young J, Fehr J, Cusini A, Battegay M, Calmy A, Orasch C, Nicca D, Bernasconi E, Jaccard R, Held L, Weber R, Weber R (2012), Outcome of smoking cessation counselling of HIV-positive persons by HIV care physicians., in HIV medicine, 13(7), 387-97.
The effect of efavirenz versus nevirapine-containing regimens on immunologic, virologic and clinical outcomes in a prospective observational study.
Cain Lauren E, Phillips Andrew, Lodi Sara, Sabin Caroline, Bansi Loveleen, Justice Amy, Tate Janet, Logan Roger, Robins James M, Sterne Jonathan A C, van Sighem Ard, de Wolf Frank, Bucher Heiner C, Elzi Luigia, Touloumi Giota, Vourli Georgia, Esteve Anna, Casabona Jordi, del Amo Julia, Moreno Santiago, Seng Rémonie, Meyer Laurence, Pérez-Hoyos Santiago, Muga Roberto, Abgrall Sophie, Costagliola Dominique, Hernán Miguel A, Hernán Miguel A (2012), The effect of efavirenz versus nevirapine-containing regimens on immunologic, virologic and clinical outcomes in a prospective observational study., in AIDS (London, England), 26(13), 1691-705.
Characteristics of HIV patients referred to a medication adherence program in Switzerland.
Krummenacher Isabelle, Cavassini Matthias, Bugnon Olivier, Schneider Marie P (2012), Characteristics of HIV patients referred to a medication adherence program in Switzerland., in International journal of clinical pharmacy, 34(3), 426-31.
Effect of mutation and genetic background on drug resistance in Mycobacterium tuberculosis.
Fenner Lukas, Egger Matthias, Bodmer Thomas, Altpeter Ekkehardt, Zwahlen Marcel, Jaton Katia, Pfyffer Gaby E, Borrell Sonia, Dubuis Olivier, Bruderer Thomas, Siegrist Hans H, Furrer Hansjakob, Calmy Alexandra, Fehr Jan, Stalder Jesica Mazza, Ninet Béatrice, Böttger Erik C, Gagneux Sebastien, Gagneux Sebastien (2012), Effect of mutation and genetic background on drug resistance in Mycobacterium tuberculosis., in Antimicrobial agents and chemotherapy, 56(6), 3047-53.
Population pharmacokinetic analysis and pharmacogenetics of raltegravir in HIV-positive and healthy individuals.
Arab-Alameddine Mona, Fayet-Mello Aurélie, Lubomirov Rubin, Neely Michael, di Iulio Julia, Owen Andrew, Boffito Marta, Cavassini Matthias, Günthard Huldrych F, Rentsch Katharina, Buclin Thierry, Aouri Manel, Telenti Amalio, Decosterd Laurent Arthur, Rotger Margalida, Csajka Chantal, Csajka Chantal (2012), Population pharmacokinetic analysis and pharmacogenetics of raltegravir in HIV-positive and healthy individuals., in Antimicrobial agents and chemotherapy, 56(6), 2959-66.
Parvovirus 4 infection and clinical outcome in high-risk populations.
Simmons Ruth, Sharp Colin, McClure C Patrick, Rohrbach Janine, Kovari Helen, Frangou Eleni, Simmonds Peter, Irving Will, Rauch Andri, Bowness Paul, Klenerman Paul, Klenerman Paul (2012), Parvovirus 4 infection and clinical outcome in high-risk populations., in The Journal of infectious diseases, 205(12), 1816-20.
Small dense lipoproteins, apolipoprotein B, and risk of coronary events in HIV-infected patients on antiretroviral therapy: the Swiss HIV Cohort Study.
Bucher Heiner C, Richter Werner, Glass Tracy R, Magenta Lorenzo, Wang Qing, Cavassini Matthias, Vernazza Pietro, Hirschel Bernard, Weber Rainer, Furrer Hansjakob, Battegay Manuel, Bernasconi Enos (2012), Small dense lipoproteins, apolipoprotein B, and risk of coronary events in HIV-infected patients on antiretroviral therapy: the Swiss HIV Cohort Study., in Journal of acquired immune deficiency syndromes (1999), 60(2), 135-42.
Impact of antiretroviral therapy on tuberculosis incidence among HIV-positive patients in high-income countries.
del Amo Julia, Moreno Santiago, Bucher Heiner C, Furrer Hansjakob, Logan Roger, Sterne Jonathan, Pérez-Hoyos Santiago, Jarrín Inma, Phillips Andrew, Lodi Sara, van Sighem Ard, de Wolf Wolf, Sabin Caroline, Bansi Loveleen, Justice Amy, Goulet Joseph, Miró José M, Ferrer Elena, Meyer Laurence, Seng Rémonie, Toulomi Giota, Gargalianos Panagiotis, Costagliola Dominique, Abgrall Sophie, Hernán Miguel A, Hernán Miguel A (2012), Impact of antiretroviral therapy on tuberculosis incidence among HIV-positive patients in high-income countries., in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 54(9), 1364-72.
All-cause mortality in treated HIV-infected adults with CD4 ≥500/mm3 compared with the general population: evidence from a large European observational cohort collaboration.
Collaboration of Observational HIV Epidemiological Research Europe (COHERE) in EuroCoord, Lewden Charlotte, Bouteloup Vincent, De Wit Stéphane, Sabin Caroline, Mocroft Amanda, Wasmuth Jan Christian, van Sighem Ard, Kirk Ole, Obel Niels, Panos George, Ghosn Jade, Dabis François, Mary-Krause Murielle, Leport Catherine, Perez-Hoyos Santiago, Sobrino-Vegas Paz, Stephan Christoph, Castagna Antonella, Antinori Andrea, d'Arminio Monforte Antonella, Torti Carlo, Mussini Cristina, Isern Virginia, Calmy Alexandra, Teira Ramón, Egger Matthias, Grarup Jesper, Chêne Geneviève (2012), All-cause mortality in treated HIV-infected adults with CD4 ≥500/mm3 compared with the general population: evidence from a large European observational cohort collaboration., in International journal of epidemiology, 41(2), 433-45.
Diagnostic performance of line-immunoassay based algorithms for incident HIV-1 infection.
Schüpbach Jörg, Bisset Leslie R, Gebhardt Martin D, Regenass Stephan, Bürgisser Philippe, Gorgievski Meri, Klimkait Thomas, Andreutti Corinne, Martinetti Gladys, Niederhauser Christoph, Yerly Sabine, Pfister Stefan, Schultze Detlev, Brandenberger Marcel, Schöni-Affolter Franziska, Scherrer Alexandra U, Günthard Huldrych F, Günthard Huldrych F (2012), Diagnostic performance of line-immunoassay based algorithms for incident HIV-1 infection., in BMC infectious diseases, 12, 88-88.
Predictive cross-validation for the choice of linear mixed-effects models with application to data from the Swiss HIV Cohort Study.
Braun Julia, Held Leonhard, Ledergerber Bruno (2012), Predictive cross-validation for the choice of linear mixed-effects models with application to data from the Swiss HIV Cohort Study., in Biometrics, 68(1), 53-61.
Renal function in patients with HIV starting therapy with tenofovir and either efavirenz, lopinavir or atazanavir.
Young Jim, Schäfer Juliane, Fux Christoph A, Furrer Hansjakob, Bernasconi Enos, Vernazza Pietro, Calmy Alexandra, Cavassini Matthias, Weber Rainer, Battegay Manuel, Bucher Heiner C, Bucher Heiner C (2012), Renal function in patients with HIV starting therapy with tenofovir and either efavirenz, lopinavir or atazanavir., in AIDS (London, England), 26(5), 567-75.
Calendar time trends in the incidence and prevalence of triple-class virologic failure in antiretroviral drug-experienced people with HIV in Europe.
Pursuing Later Treatment Options II (PLATO II) project team, Pursuing Later Treatment Options II (PLATO II) project team, Nakagawa Fumiyo, Lodwick Rebecca, Costagliola Dominique, van Sighem Ard, Torti Carlo, Podzamczer Daniel, Mocroft Amanda, Ledergerber Bruno, Dorrucci Maria, Cozzi-Lepri Alessandra, Jansen Klaus, Masquelier Bernard, García Federico, De Wit Stephane, Stephan Christoph, Obel Niels, Fätkenhaeuer Gerd, Castagna Antonella, Sambatakou Helen, Mussini Cristina, Ghosn Jade, Zangerle Robert, Duval Xavier, Meyer Laurence, Perez-Hoyos Santiago, Fabre Colin Céline, Kjaer Jesper, Chene Genevieve, Grarup Jesper, Phillips Andrew (2012), Calendar time trends in the incidence and prevalence of triple-class virologic failure in antiretroviral drug-experienced people with HIV in Europe., in Journal of acquired immune deficiency syndromes (1999), 59(3), 294-9.
Mycobacterium tuberculosis transmission in a country with low tuberculosis incidence: role of immigration and HIV infection.
Fenner Lukas, Gagneux Sebastien, Helbling Peter, Battegay Manuel, Rieder Hans L, Pfyffer Gaby E, Zwahlen Marcel, Furrer Hansjakob, Siegrist Hans H, Fehr Jan, Dolina Marisa, Calmy Alexandra, Stucki David, Jaton Katia, Janssens Jean-Paul, Stalder Jesica Mazza, Bodmer Thomas, Ninet Beatrice, Böttger Erik C, Egger Matthias, Egger Matthias, Egger Matthias (2012), Mycobacterium tuberculosis transmission in a country with low tuberculosis incidence: role of immigration and HIV infection., in Journal of clinical microbiology, 50(2), 388-95.
Outcomes of antiretroviral therapy in the Swiss HIV Cohort Study: latent class analysis.
Keiser Olivia, Spycher Ben, Rauch Andri, Calmy Alexandra, Cavassini Matthias, Glass Tracy R, Nicca Dunja, Ledergerber Bruno, Egger Matthias, Egger Matthias (2012), Outcomes of antiretroviral therapy in the Swiss HIV Cohort Study: latent class analysis., in AIDS and behavior, 16(2), 245-55.
Participation, characteristics and retention rates of HIV-positive immigrants in the Swiss HIV Cohort Study.
Thierfelder C, Weber R, Elzi L, Furrer H, Cavassini M, Calmy A, Bernasconi E, Gutmann C, Ledergerber B, Ledergerber B (2012), Participation, characteristics and retention rates of HIV-positive immigrants in the Swiss HIV Cohort Study., in HIV medicine, 13(2), 118-26.
The effect of injecting drug use history on disease progression and death among HIV-positive individuals initiating combination antiretroviral therapy: collaborative cohort analysis.
Murray M, Hogg R S, Lima V D, May M T, Moore D M, Abgrall S, Bruyand M, D'Arminio Monforte A, Tural C, Gill M J, Harris R J, Reiss P, Justice A, Kirk O, Saag M, Smith C J, Weber R, Rockstroh J, Khaykin P, Sterne J A C, Sterne J A C (2012), The effect of injecting drug use history on disease progression and death among HIV-positive individuals initiating combination antiretroviral therapy: collaborative cohort analysis., in HIV medicine, 13(2), 89-97.
Trends in virological and clinical outcomes in individuals with HIV-1 infection and virological failure of drugs from three antiretroviral drug classes: a cohort study.
Pursuing Later Treatment Option II (PLATO II) project team, Pursuing Later Treatment Option II (PLATO II) project team, Costagliola Dominique, Lodwick Rebecca, Ledergerber Bruno, Torti Carlo, van Sighem Ard, Podzamczer Daniel, Mocroft Amanda, Dorrucci Maria, Masquelier Bernard, de Luca Andrea, Jansen Klaus, De Wit Stephane, Obel Niels, Fätkenheuer Gerd, Touoloumi Giota, Mussini Cristina, Castagna Antonella, Stephan Cristoph, García Federico, Zangerle Robert, Duval Xavier, Pérez-Hoyos Santiago, Meyer Laurence, Ghosn Jade, Fabre-Colin Céline, Kjaer Jesper, Chene Genevieve, Grarup Jesper, Phillips Andrew (2012), Trends in virological and clinical outcomes in individuals with HIV-1 infection and virological failure of drugs from three antiretroviral drug classes: a cohort study., in The Lancet. Infectious diseases, 12(2), 119-27.
Role of retroviral restriction factors in the interferon-α-mediated suppression of HIV-1 in vivo.
Pillai Satish K, Abdel-Mohsen Mohamed, Guatelli John, Skasko Mark, Monto Alexander, Fujimoto Katsuya, Yukl Steven, Greene Warner C, Kovari Helen, Rauch Andri, Fellay Jacques, Battegay Manuel, Hirschel Bernard, Witteck Andrea, Bernasconi Enos, Ledergerber Bruno, Günthard Huldrych F, Wong Joseph K, Wong Joseph K (2012), Role of retroviral restriction factors in the interferon-α-mediated suppression of HIV-1 in vivo., in Proceedings of the National Academy of Sciences of the United States of America, 109(8), 3035-40.
Evaluation of HIV protease inhibitor use and the risk of sudden death or nonhemorrhagic stroke.
Worm S W, Kamara D A, Reiss P, Fontas E, De Wit S, El-Sadr W, D'Arminio Monforte A, Law M, Phillips A, Ryom L, Dabis F, Weber R, Sabin C, Lundgren J D, Lundgren J D (2012), Evaluation of HIV protease inhibitor use and the risk of sudden death or nonhemorrhagic stroke., in The Journal of infectious diseases, 205(4), 535-9.
Polymorphic mutations associated with the emergence of the multinucleoside/tide resistance mutations 69 insertion and Q151M.
Scherrer Alexandra U, von Wyl Viktor, Götte Matthias, Klimkait Thomas, Cellerai Cristina, Yerly Sabine, Böni Jürg, Held Leonhard, Ledergerber Bruno, Günthard Huldrych F, Günthard Huldrych F (2012), Polymorphic mutations associated with the emergence of the multinucleoside/tide resistance mutations 69 insertion and Q151M., in Journal of acquired immune deficiency syndromes (1999), 59(2), 105-12.
Lung cancer in the Swiss HIV Cohort Study: role of smoking, immunodeficiency and pulmonary infection.
Clifford G M, Lise M, Franceschi S, Egger M, Bouchardy C, Korol D, Levi F, Ess S, Jundt G, Wandeler G, Fehr J, Schmid P, Battegay M, Bernasconi E, Cavassini M, Calmy A, Keiser O, Schöni-Affolter F, Schöni-Affolter F (2012), Lung cancer in the Swiss HIV Cohort Study: role of smoking, immunodeficiency and pulmonary infection., in British journal of cancer, 106(3), 447-52.
Estimating the basic reproductive number from viral sequence data.
Stadler Tanja, Kouyos Roger, von Wyl Viktor, Yerly Sabine, Böni Jürg, Bürgisser Philippe, Klimkait Thomas, Joos Beda, Rieder Philip, Xie Dong, Günthard Huldrych F, Drummond Alexei J, Bonhoeffer Sebastian, Bonhoeffer Sebastian (2012), Estimating the basic reproductive number from viral sequence data., in Molecular biology and evolution, 29(1), 347-57.
Impaired antibody memory to varicella zoster virus in HIV-infected children: low antibody levels and avidity*.
L'Huillier A G, Ferry T, Courvoisier D S, Aebi C, Cheseaux J-J, Kind C, Rudin C, Nadal D, Hirschel B, Sottas C, Siegrist C-A, Posfay-Barbe K M, Posfay-Barbe K M, Posfay-Barbe K M, Posfay-Barbe K M, Posfay-Barbe K M (2012), Impaired antibody memory to varicella zoster virus in HIV-infected children: low antibody levels and avidity*., in HIV medicine, 13(1), 54-61.
The rate of accumulation of nonnucleoside reverse transcriptase inhibitor (NNRTI) resistance in patients kept on a virologically failing regimen containing an NNRTI*.
Cozzi-Lepri A, Paredes A, Phillips A N, Clotet B, Kjaer J, Von Wyl V, Kronborg G, Castagna A, Bogner J R, Lundgren J D, Lundgren J D (2012), The rate of accumulation of nonnucleoside reverse transcriptase inhibitor (NNRTI) resistance in patients kept on a virologically failing regimen containing an NNRTI*., in HIV medicine, 13(1), 62-72.
Long-term exposure to combination antiretroviral therapy and risk of death from specific causes: no evidence for any previously unidentified increased risk due to antiretroviral therapy.
Kowalska Justyna D, Reekie Joanne, Mocroft Amanda, Reiss Peter, Ledergerber Bruno, Gatell Jose, d'Arminio Monforte Antonella, Phillips Andrew, Lundgren Jens D, Kirk Ole, Kirk Ole (2012), Long-term exposure to combination antiretroviral therapy and risk of death from specific causes: no evidence for any previously unidentified increased risk due to antiretroviral therapy., in AIDS (London, England), 26(3), 315-23.
Is the virulence of HIV changing? A meta-analysis of trends in prognostic markers of HIV disease progression and transmission.
Herbeck Joshua T, Müller Viktor, Maust Brandon S, Ledergerber Bruno, Torti Carlo, Di Giambenedetto Simona, Gras Luuk, Günthard Huldrych F, Jacobson Lisa P, Mullins James I, Gottlieb Geoffrey S (2012), Is the virulence of HIV changing? A meta-analysis of trends in prognostic markers of HIV disease progression and transmission., in AIDS (London, England), 26(2), 193-205.
Novel adenovirus-based vaccines induce broad and sustained T cell responses to HCV in man.
Barnes Eleanor, Folgori Antonella, Capone Stefania, Swadling Leo, Aston Stephen, Kurioka Ayako, Meyer Joel, Huddart Rachel, Smith Kira, Townsend Rachel, Brown Anthony, Antrobus Richard, Ammendola Virginia, Naddeo Mariarosaria, O'Hara Geraldine, Willberg Chris, Harrison Abby, Grazioli Fabiana, Esposito Maria Luisa, Siani Loredana, Traboni Cinzia, Oo Ye, Adams David, Hill Adrian, Colloca Stefano, Nicosia Alfredo, Cortese Riccardo, Klenerman Paul (2012), Novel adenovirus-based vaccines induce broad and sustained T cell responses to HCV in man., in Science translational medicine, 4(115), 115-1.
Vaccine vectors derived from a large collection of simian adenoviruses induce potent cellular immunity across multiple species.
Colloca Stefano, Barnes Eleanor, Folgori Antonella, Ammendola Virginia, Capone Stefania, Cirillo Agostino, Siani Loredana, Naddeo Mariarosaria, Grazioli Fabiana, Esposito Maria Luisa, Ambrosio Maria, Sparacino Angela, Bartiromo Marta, Meola Annalisa, Smith Kira, Kurioka Ayako, O'Hara Geraldine A, Ewer Katie J, Anagnostou Nicholas, Bliss Carly, Hill Adrian V S, Traboni Cinzia, Klenerman Paul, Cortese Riccardo, Nicosia Alfredo (2012), Vaccine vectors derived from a large collection of simian adenoviruses induce potent cellular immunity across multiple species., in Science translational medicine, 4(115), 115-2.
Incidence of HIV-1 drug resistance among antiretroviral treatment-naive individuals starting modern therapy combinations.
von Wyl Viktor, Yerly Sabine, Böni Jürg, Shah Cyril, Cellerai Cristina, Klimkait Thomas, Battegay Manuel, Bernasconi Enos, Cavassini Matthias, Furrer Hansjakob, Hirschel Bernard, Vernazza Pietro L, Ledergerber Bruno, Günthard Huldrych F, Günthard Huldrych F (2012), Incidence of HIV-1 drug resistance among antiretroviral treatment-naive individuals starting modern therapy combinations., in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 54(1), 131-40.
Longer term clinical and virological outcome of sub-Saharan African participants on antiretroviral treatment in the Swiss HIV Cohort Study.
Staehelin Cornelia, Keiser Olivia, Calmy Alexandra, Weber Rainer, Elzi Luigia, Cavassini Matthias, Schmid Patrick, Bernasconi Enos, Furrer Hansjakob, Furrer Hansjakob (2012), Longer term clinical and virological outcome of sub-Saharan African participants on antiretroviral treatment in the Swiss HIV Cohort Study., in Journal of acquired immune deficiency syndromes (1999), 59(1), 79-85.
Uptake of combination antiretroviral therapy and HIV disease progression according to geographical origin in seroconverters in Europe, Canada, and Australia.
Jarrin Inma, Pantazis Nikos, Gill M John, Geskus Ronald, Perez-Hoyos Santiago, Meyer Laurence, Prins Maria, Touloumi Giota, Johnson Anne, Hamouda Osamah, de Olalla Patricia García, Porter Kholoud, del Amo Julia, del Amo Julia (2012), Uptake of combination antiretroviral therapy and HIV disease progression according to geographical origin in seroconverters in Europe, Canada, and Australia., in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 54(1), 111-8.
A comparison of initial antiretroviral therapy in the Swiss HIV Cohort Study and the recommendations of the International AIDS Society-USA.
Wandeler Gilles, Keiser Olivia, Hirschel Bernard, Günthard Huldrych F, Bernasconi Enos, Battegay Manuel, Clerc Olivier, Vernazza Pietro L, Furrer Hansjakob, Furrer Hansjakob (2011), A comparison of initial antiretroviral therapy in the Swiss HIV Cohort Study and the recommendations of the International AIDS Society-USA., in PloS one, 6(12), 27903-27903.
A standardized algorithm for determining the underlying cause of death in HIV infection as AIDS or non-AIDS related: results from the EuroSIDA study.
Kowalska Justyna D, Mocroft Amanda, Ledergerber Bruno, Florence Eric, Ristola Matti, Begovac Josip, Sambatakou Helen, Pedersen Court, Lundgren Jens D, Kirk Ole, Kirk Ole (2011), A standardized algorithm for determining the underlying cause of death in HIV infection as AIDS or non-AIDS related: results from the EuroSIDA study., in HIV clinical trials, 12(2), 109-117.
Effect of early antiretroviral therapy during primary HIV-1 infection on cell-associated HIV-1 DNA and plasma HIV-1 RNA.
Gianella Sara, von Wyl Viktor, Fischer Marek, Niederoest Barbara, Battegay Manuel, Bernasconi Enos, Cavassini Matthias, Rauch Andri, Hirschel Bernard, Vernazza Pietro, Weber Rainer, Joos Beda, Günthard Huldrych F, Günthard Huldrych F (2011), Effect of early antiretroviral therapy during primary HIV-1 infection on cell-associated HIV-1 DNA and plasma HIV-1 RNA., in Antiviral therapy, 16(4), 535-45.
Estimating loss to follow-up in HIV-infected patients on antiretroviral therapy: the effect of the competing risk of death in Zambia and Switzerland.
Schöni-Affolter Franziska, Keiser Olivia, Mwango Albert, Stringer Jeffrey, Ledergerber Bruno, Mulenga Lloyd, Bucher Heiner C, Westfall Andrew O, Calmy Alexandra, Boulle Andrew, Chintu Namwinga, Egger Matthias, Chi Benjamin H, Chi Benjamin H, Chi Benjamin H (2011), Estimating loss to follow-up in HIV-infected patients on antiretroviral therapy: the effect of the competing risk of death in Zambia and Switzerland., in PloS one, 6(12), 27919-27919.
Management of hepatitis C virus (HCV) infection in drug substitution programs.
Witteck Andrea, Schmid Patrick, Hensel-Koch Katharina, Thurnheer Maria C, Bruggmann Philip, Vernazza Pietro, Vernazza Pietro (2011), Management of hepatitis C virus (HCV) infection in drug substitution programs., in Swiss medical weekly, 141, 13193-13193.
Predictors of having a resistance test following confirmed virological failure of combination antiretroviral therapy: data from EuroSIDA.
Fox Zoe V, Cozzi-Lepri Alessandro, D'Arminio Monforte Antonella, Karlsson Anders, Phillips Andrew N, Kronborg Gitte, Kjaer Jesper, Clotet Bonaventura, Lundgren Jens D, Lundgren Jens D (2011), Predictors of having a resistance test following confirmed virological failure of combination antiretroviral therapy: data from EuroSIDA., in Antiviral therapy, 16(5), 781-5.
Successful efavirenz dose reduction guided by therapeutic drug monitoring
Fayet Mello Aurélie, Buclin Thierry, Decosterd Laurent A, Delhumeau Cécile, di Iulio Julia, Fleurent Alessandra, Schneider Marie-Paule, Cavassini Matthias, Telenti Amalio, Hirschel Bernard, Calmy Alexandra (2011), Successful efavirenz dose reduction guided by therapeutic drug monitoring, in Antiviral therapy, 16(2), 189-97.
Early antiretroviral therapy during primary HIV-1 infection results in a transient reduction of the viral setpoint upon treatment interruption.
Wyl Viktor von, Gianella Sara, Fischer Marek, Niederoest Barbara, Kuster Herbert, Battegay Manuel, Bernasconi Enos, Cavassini Matthias, Rauch Andri, Hirschel Bernard, Vernazza Pietro, Weber Rainer, Joos Beda, Günthard Huldrych F, Günthard Huldrych F (2011), Early antiretroviral therapy during primary HIV-1 infection results in a transient reduction of the viral setpoint upon treatment interruption., in PloS one, 6(11), 27463-27463.
Improved virological outcome in White patients infected with HIV-1 non-B subtypes compared to subtype B.
Scherrer Alexandra U, Ledergerber Bruno, von Wyl Viktor, Böni Jürg, Yerly Sabine, Klimkait Thomas, Bürgisser Philippe, Rauch Andri, Hirschel Bernard, Cavassini Matthias, Elzi Luigia, Vernazza Pietro L, Bernasconi Enos, Held Leonhard, Günthard Huldrych F, Günthard Huldrych F (2011), Improved virological outcome in White patients infected with HIV-1 non-B subtypes compared to subtype B., in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 53(11), 1143-52.
Morbidity and aging in HIV-infected persons: the Swiss HIV cohort study.
Hasse Barbara, Ledergerber Bruno, Furrer Hansjakob, Battegay Manuel, Hirschel Bernhard, Cavassini Matthias, Bertisch Barbara, Bernasconi Enos, Weber Rainer, Weber Rainer (2011), Morbidity and aging in HIV-infected persons: the Swiss HIV cohort study., in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 53(11), 1130-9.
Impact of a nurse vaccination program on hepatitis B immunity in a Swiss HIV clinic.
Boillat Blanco Noémie, Probst Arnold, Da Costa Vreneli Waelti, Giulieri Stefano, Bernasconi Enos, Calmy Alexandra, Elzi Luigia, Rauch Andri, Weber Rainer, Bertisch Barbara, Cavassini Matthias, Bochud Pierre-Yves (2011), Impact of a nurse vaccination program on hepatitis B immunity in a Swiss HIV clinic., in Journal of acquired immune deficiency syndromes (1999), 58(5), 472-4.
Copy number variation of KIR genes influences HIV-1 control.
Pelak Kimberly, Need Anna C, Fellay Jacques, Shianna Kevin V, Feng Sheng, Urban Thomas J, Ge Dongliang, De Luca Andrea, Martinez-Picado Javier, Wolinsky Steven M, Martinson Jeremy J, Jamieson Beth D, Bream Jay H, Martin Maureen P, Borrow Persephone, Letvin Norman L, McMichael Andrew J, Haynes Barton F, Telenti Amalio, Carrington Mary, Goldstein David B, Alter Galit, Alter Galit (2011), Copy number variation of KIR genes influences HIV-1 control., in PLoS biology, 9(11), 1001208-1001208.
Assessing predicted HIV-1 replicative capacity in a clinical setting.
Kouyos Roger D, von Wyl Viktor, Hinkley Trevor, Petropoulos Christos J, Haddad Mojgan, Whitcomb Jeannette M, Böni Jürg, Yerly Sabine, Cellerai Cristina, Klimkait Thomas, Günthard Huldrych F, Bonhoeffer Sebastian, Bonhoeffer Sebastian (2011), Assessing predicted HIV-1 replicative capacity in a clinical setting., in PLoS pathogens, 7(11), 1002321-1002321.
Systemic antibody responses to gut commensal bacteria during chronic HIV-1 infection.
Haas Anna, Zimmermann Kathrin, Graw Frederik, Slack Emma, Rusert Peter, Ledergerber Bruno, Bossart Walter, Weber Rainer, Thurnheer Maria C, Battegay Manuel, Hirschel Bernard, Vernazza Pietro, Patuto Nicola, Macpherson Andrew J, Günthard Huldrych F, Oxenius Annette, Oxenius Annette (2011), Systemic antibody responses to gut commensal bacteria during chronic HIV-1 infection., in Gut, 60(11), 1506-19.
Early antiretroviral therapy in HIV-1-infected infants, 1996-2008: treatment response and duration of first-line regimens.
Judd Ali, Judd Ali (2011), Early antiretroviral therapy in HIV-1-infected infants, 1996-2008: treatment response and duration of first-line regimens., in AIDS (London, England), 25(18), 2279-87.
Fatal and nonfatal AIDS and non-AIDS events in HIV-1-positive individuals with high CD4 cell counts according to viral load strata.
Reekie Joanne, Gatell Jose M, Yust Israel, Bakowska Elzbieta, Rakhmanova Aza, Losso Marcelo, Krasnov Maksym, Francioli Patrick, Kowalska Justyna D, Mocroft Amanda, Mocroft Amanda (2011), Fatal and nonfatal AIDS and non-AIDS events in HIV-1-positive individuals with high CD4 cell counts according to viral load strata., in AIDS (London, England), 25(18), 2259-68.
A polymorphism in the leptin gene promoter is associated with anemia in patients with HIV disease.
Vanasse Gary J, Jeong Jee-Yeong, Tate Janet, Bathulapalli Harini, Anderson Damon, Steen Hanno, Fleming Mark, Mattocks Kristin, Telenti Amalio, Fellay Jacques, Justice Amy C, Berliner Nancy (2011), A polymorphism in the leptin gene promoter is associated with anemia in patients with HIV disease., in Blood, 118(20), 5401-8.
Improved sensitivity of an interferon-gamma release assay (T-SPOT.TB™) in combination with tuberculin skin test for the diagnosis of latent tuberculosis in the presence of HIV co-infection.
Elzi Luigia, Steffen Ingrid, Furrer Hansjakob, Fehr Jan, Cavassini Matthias, Hirschel Bernard, Hoffmann Matthias, Bernasconi Enos, Bassetti Stefano, Battegay Manuel (2011), Improved sensitivity of an interferon-gamma release assay (T-SPOT.TB™) in combination with tuberculin skin test for the diagnosis of latent tuberculosis in the presence of HIV co-infection., in BMC infectious diseases, 11, 319-319.
Comparative effectiveness of initial antiretroviral therapy regimens: ACTG 5095 and 5142 clinical trials relative to ART-CC cohort study.
Mugavero Michael J, May Margaret, Ribaudo Heather J, Gulick Roy M, Riddler Sharon A, Haubrich Richard, Napravnik Sonia, Abgrall Sophie, Phillips Andrew, Harris Ross, Gill M John, de Wolf Frank, Hogg Robert, Günthard Huldrych F, Chêne Geneviève, D'Arminio Monforte Antonella, Guest Jodie L, Smith Colette, Murillas Javier, Berenguer Juan, Wyen Christoph, Domingo Pere, Kitahata Mari M, Sterne Jonathan A C, Saag Michael S, Saag Michael S, Saag Michael S, Saag Michael S, Saag Michael S (2011), Comparative effectiveness of initial antiretroviral therapy regimens: ACTG 5095 and 5142 clinical trials relative to ART-CC cohort study., in Journal of acquired immune deficiency syndromes (1999), 58(3), 253-60.
JC virus antibody and viremia as predictors of progressive multifocal leukoencephalopathy in human immunodeficiency virus-1-infected individuals.
Viscidi Raphael P, Khanna Nina, Tan Chen S, Li Xiuhung, Jacobson Lisa, Clifford David B, Nath Avindra, Margolick Joseph B, Shah Keerti V, Hirsch Hans H, Koralnik Igor J (2011), JC virus antibody and viremia as predictors of progressive multifocal leukoencephalopathy in human immunodeficiency virus-1-infected individuals., in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 53(7), 711-5.
Analyzing direct and indirect effects of treatment using dynamic path analysis applied to data from the Swiss HIV Cohort Study.
Røysland Kjetil, Gran Jon Michael, Ledergerber Bruno, von Wyl Viktor, Young James, Aalen Odd O (2011), Analyzing direct and indirect effects of treatment using dynamic path analysis applied to data from the Swiss HIV Cohort Study., in Statistics in medicine, 30(24), 2947-58.
Time from human immunodeficiency virus seroconversion to reaching CD4+ cell count thresholds <200, <350, and <500 Cells/mm³: assessment of need following changes in treatment guidelines.
Lodi Sara, Phillips Andrew, Touloumi Giota, Geskus Ronald, Meyer Laurence, Thiébaut Rodolphe, Pantazis Nikos, Amo Julia Del, Johnson Anne M, Babiker Abdel, Porter Kholoud, Porter Kholoud (2011), Time from human immunodeficiency virus seroconversion to reaching CD4+ cell count thresholds <200, <350, and <500 Cells/mm³: assessment of need following changes in treatment guidelines., in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 53(8), 817-25.
The role of migration and domestic transmission in the spread of HIV-1 non-B subtypes in Switzerland.
von Wyl Viktor, Kouyos Roger D, Yerly Sabine, Böni Jürg, Shah Cyril, Bürgisser Philippe, Klimkait Thomas, Weber Rainer, Hirschel Bernard, Cavassini Matthias, Staehelin Cornelia, Battegay Manuel, Vernazza Pietro L, Bernasconi Enos, Ledergerber Bruno, Bonhoeffer Sebastian, Günthard Huldrych F, Günthard Huldrych F (2011), The role of migration and domestic transmission in the spread of HIV-1 non-B subtypes in Switzerland., in The Journal of infectious diseases, 204(7), 1095-103.
Ageing with HIV: medication use and risk for potential drug-drug interactions.
Marzolini Catia, Back David, Weber Rainer, Furrer Hansjakob, Cavassini Matthias, Calmy Alexandra, Vernazza Pietro, Bernasconi Enos, Khoo Saye, Battegay Manuel, Elzi Luigia, Elzi Luigia (2011), Ageing with HIV: medication use and risk for potential drug-drug interactions., in The Journal of antimicrobial chemotherapy, 66(9), 2107-11.
High specificity of line-immunoassay based algorithms for recent HIV-1 infection independent of viral subtype and stage of disease.
Schüpbach Jörg, Bisset Leslie R, Regenass Stephan, Bürgisser Philippe, Gorgievski Meri, Steffen Ingrid, Andreutti Corinne, Martinetti Gladys, Shah Cyril, Yerly Sabine, Klimkait Thomas, Gebhardt Martin, Schöni-Affolter Franziska, Rickenbach Martin, Rickenbach Martin, Barth J, Battegay M, Bernascon E, Böni J, Bucher H C, Bürgisser P, Burton-Jeangros C, Calmy A, Cavassini M, Dubs R, Egger M, Elzi L, Fehr J, Fischer M, Flepp M, Francioli P, Furrer H, Fux C A, Gorgievski M, Günthard H, Hasse B, Hirsch H H, Hirschel B, Hösli I, Kahlert C, Kaiser L, Keiser O, Kind C, Klimkait T, Kovari H, Ledergerber B, Martinetti G, Martinez de Tejada B, Müller N, Nadal D, Pantaleo G, Rauch A, Regenass S, Rickenbach M, Rudin C, Schmid P, Schultze D, Schöni-Affolter F, Schüpbach J, Speck R, Taffé P, Telenti A, Trkola A, Vernazza P, von Wyl V, Weber R, Yerly S (2011), High specificity of line-immunoassay based algorithms for recent HIV-1 infection independent of viral subtype and stage of disease., in BMC infectious diseases, 11, 254-254.
Timing of HAART initiation and clinical outcomes in human immunodeficiency virus type 1 seroconverters.
Writing Committee for the CASCADE Collaboration (2011), Timing of HAART initiation and clinical outcomes in human immunodeficiency virus type 1 seroconverters., in Archives of internal medicine, 171(17), 1560-9.
A376S in the connection subdomain of HIV-1 reverse transcriptase confers increased risk of virological failure to nevirapine therapy.
Paredes Roger, Puertas Maria Carmen, Bannister Wendy, Kisic Mónica, Cozzi-Lepri Alessandro, Pou Christian, Bellido Rocío, Betancor Gilberto, Bogner Johannes, Gargalianos Panagiotis, Bánhegyi Dénes, Clotet Bonaventura, Lundgren Jens, Menéndez-Arias Luis, Martinez-Picado Javier, Martinez-Picado Javier (2011), A376S in the connection subdomain of HIV-1 reverse transcriptase confers increased risk of virological failure to nevirapine therapy., in The Journal of infectious diseases, 204(5), 741-52.
Clinical relevance of cytomegalovirus viraemia(*,†).
El Amari E Boffi, Combescure C, Yerly S, Calmy A, Kaiser L, Hasse B, Furrer H, Cavassini M, Vernazza P, Hirsch Hh, Bernasconi E, Hirschel B, Hirschel B (2011), Clinical relevance of cytomegalovirus viraemia(*,†)., in HIV medicine, 12(7), 394-402.
Rates of cardiovascular disease following smoking cessation in patients with HIV infection: results from the D:A:D study(*).
Petoumenos K, Worm S, Reiss P, de Wit S, d'Arminio Monforte A, Sabin C, Friis-Møller N, Weber R, Mercie P, Pradier C, El-Sadr W, Kirk O, Lundgren J, Law Mg, Law Mg (2011), Rates of cardiovascular disease following smoking cessation in patients with HIV infection: results from the D:A:D study(*)., in HIV medicine, 12(7), 412-21.
Sexual protection behavior in HIV-positive gay men: testing a modified information-motivation-behavioral skills model.
Nöstlinger Christiana, Nideröst Sibylle, Platteau Tom, Müller Matthias C, Staneková Danica, Gredig Daniel, Roulin Christophe, Rickenbach Martin, Colebunders Robert, Colebunders Robert (2011), Sexual protection behavior in HIV-positive gay men: testing a modified information-motivation-behavioral skills model., in Archives of sexual behavior, 40(4), 817-27.
The impact of fasting on the interpretation of triglyceride levels for predicting myocardial infarction risk in HIV-positive individuals: the D:A:D study.
Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) Study (2011), The impact of fasting on the interpretation of triglyceride levels for predicting myocardial infarction risk in HIV-positive individuals: the D:A:D study., in The Journal of infectious diseases, 204(4), 521-5.
Outcome and prognostic factors in HIV-1-infected patients on dialysis in the cART era: a GESIDA/SEN cohort study.
Trullàs Joan-Carles, Cofan Federico, Barril Guillermina, Martínez-Castelao Alberto, Jofre Rosa, Rivera Maite, Martínez-Ara Jorge, Ros Silvia, Perez Iñaki, Moreno Asunción, Miró Jose M, Miró Jose M (2011), Outcome and prognostic factors in HIV-1-infected patients on dialysis in the cART era: a GESIDA/SEN cohort study., in Journal of acquired immune deficiency syndromes (1999), 57(4), 276-83.
A randomized cross-over study to compare raltegravir and efavirenz (SWITCH-ER study).
Nguyen Alain, Calmy Alexandra, Delhumeau Cecile, Mercier Isabelle, Cavassini Matthias, Mello Aurelie F, Elzi Luigia, Rauch Andri, Bernasconi Enos, Schmid Patrick, Hirschel Bernard (2011), A randomized cross-over study to compare raltegravir and efavirenz (SWITCH-ER study)., in AIDS (London, England), 25(12), 1481-7.
Cell disposition of raltegravir and newer antiretrovirals in HIV-infected patients: high inter-individual variability in raltegravir cellular penetration.
Fayet Mello Aurélie, Buclin Thierry, Franc Claudia, Colombo Sara, Cruchon Sandra, Guignard Nicole, Biollaz Jérôme, Telenti Amalio, Decosterd Laurent A, Cavassini Matthias (2011), Cell disposition of raltegravir and newer antiretrovirals in HIV-infected patients: high inter-individual variability in raltegravir cellular penetration., in The Journal of antimicrobial chemotherapy, 66(7), 1573-81.
Elevated triglycerides and risk of myocardial infarction in HIV-positive persons.
Worm Signe W, Kamara David A, Reiss Peter, Kirk Ole, El-Sadr Wafaa, Fux Christoph, Fontas Eric, Phillips Andrew, D'Arminio Monforte Antonella, De Wit Stephane, Petoumenos Kathy, Friis-Mller Nina, Mercie Patrick, Lundgren Jens D, Sabin Caroline (2011), Elevated triglycerides and risk of myocardial infarction in HIV-positive persons., in AIDS (London, England), 25(12), 1497-504.
Predictors of HIV-protection behaviour in HIV-positive men who have sex with casual male partners: a test of the explanatory power of an extended Information-Motivation-Behavioural Skills model.
Nideröst Sibylle, Gredig Daniel, Roulin Christophe, Rickenbach Martin, Rickenbach Martin, Rickenbach Martin (2011), Predictors of HIV-protection behaviour in HIV-positive men who have sex with casual male partners: a test of the explanatory power of an extended Information-Motivation-Behavioural Skills model., in AIDS care, 23(7), 908-19.
The Coding Causes of Death in HIV (CoDe) Project: initial results and evaluation of methodology.
Kowalska Justyna D, Friis-Møller Nina, Kirk Ole, Bannister Wendy, Mocroft Amanda, Sabin Caroline, Reiss Peter, Gill John, Lewden Charlotte, Phillips Andrew, D'Arminio Monforte Antonella, Law Matthew, Sterne Jonathan, De Wit Stephane, Lundgren Jens D, Lundgren Jens D, Lundgren Jens D (2011), The Coding Causes of Death in HIV (CoDe) Project: initial results and evaluation of methodology., in Epidemiology (Cambridge, Mass.), 22(4), 516-23.
Immune reconstitution and risk of Kaposi sarcoma and non-Hodgkin lymphoma in HIV-infected adults.
Jaffe Harold W, De Stavola Bianca L, Carpenter Lucy M, Porter Kholoud, Cox David R, Cox David R (2011), Immune reconstitution and risk of Kaposi sarcoma and non-Hodgkin lymphoma in HIV-infected adults., in AIDS (London, England), 25(11), 1395-403.
Comparative transcriptomics of extreme phenotypes of human HIV-1 infection and SIV infection in sooty mangabey and rhesus macaque.
Rotger Margalida, Dalmau Judith, Rauch Andri, McLaren Paul, Bosinger Steven E, Martinez Raquel, Sandler Netanya G, Roque Annelys, Liebner Julia, Battegay Manuel, Bernasconi Enos, Descombes Patrick, Erkizia Itziar, Fellay Jacques, Hirschel Bernard, Miró Jose M, Palou Eduard, Hoffmann Matthias, Massanella Marta, Blanco Julià, Woods Matthew, Günthard Huldrych F, de Bakker Paul, Douek Daniel C, Silvestri Guido, Martinez-Picado Javier, Telenti Amalio (2011), Comparative transcriptomics of extreme phenotypes of human HIV-1 infection and SIV infection in sooty mangabey and rhesus macaque., in The Journal of clinical investigation, 121(6), 2391-400.
Hepatitis E Virus seroprevalence and chronic infections in patients with HIV, Switzerland.
Kenfak-Foguena Alain, Schöni-Affolter Franziska, Bürgisser Phillippe, Witteck Andrea, Darling Katharine E A, Kovari Helen, Kaiser Laurent, Evison John-Marc, Elzi Luigia, Gurter-De La Fuente Vanina, Jost Josef, Moradpour Darius, Abravanel Florence, Izpopet Jacques, Cavassini Matthais, Cavassini Matthais (2011), Hepatitis E Virus seroprevalence and chronic infections in patients with HIV, Switzerland., in Emerging infectious diseases, 17(6), 1074-8.
Factors associated with specific causes of death amongst HIV-positive individuals in the D:A:D Study.
Data Collection on Adverse Events of Anti-HIV drugs (D:A:D) Study Group, Smith Colette, Sabin Caroline A, Lundgren Jens D, Thiebaut Rodolphe, Weber Rainer, Law Matthew, Monforte Antonella d'Arminio, Kirk Ole, Friis-Moller Nina, Phillips Andrew, Reiss Peter, El Sadr Wafaa, Pradier Christian, Worm Signe W (2011), Factors associated with specific causes of death amongst HIV-positive individuals in the D:A:D Study., in AIDS (London, England), 24(10), 1537-48.
Vitamin D and clinical disease progression in HIV infection: results from the EuroSIDA study.
Viard Jean-Paul, Souberbielle Jean-Claude, Kirk Ole, Reekie Joanne, Knysz Brygida, Losso Marcelo, Gatell Jose, Pedersen Court, Bogner Johannes R, Lundgren Jens D, Mocroft Amanda, Mocroft Amanda (2011), Vitamin D and clinical disease progression in HIV infection: results from the EuroSIDA study., in AIDS (London, England), 25(10), 1305-15.
HIV-1-related Hodgkin lymphoma in the era of combination antiretroviral therapy: incidence and evolution of CD4⁺ T-cell lymphocytes.
Bohlius Julia, Schmidlin Kurt, Boué François, Fätkenheuer Gerd, May Margaret, Caro-Murillo Ana Maria, Mocroft Amanda, Bonnet Fabrice, Clifford Gary, Paparizos Vassilios, Miro Jose M, Obel Niels, Prins Maria, Chêne Geneviève, Egger Matthias, Egger Matthias (2011), HIV-1-related Hodgkin lymphoma in the era of combination antiretroviral therapy: incidence and evolution of CD4⁺ T-cell lymphocytes., in Blood, 117(23), 6100-8.
Impact of phenotype definition on genome-wide association signals: empirical evaluation in human immunodeficiency virus type 1 infection.
Evangelou Evangelos, Fellay Jacques, Colombo Sara, Martinez-Picado Javier, Obel Niels, Goldstein David B, Telenti Amalio, Ioannidis John P A (2011), Impact of phenotype definition on genome-wide association signals: empirical evaluation in human immunodeficiency virus type 1 infection., in American journal of epidemiology, 173(11), 1336-42.
A comparison of the long-term durability of nevirapine, efavirenz and lopinavir in routine clinical practice in Europe: a EuroSIDA study.
Reekie J, Reiss P, Ledergerber B, Sedlacek D, Parczewski M, Gatell J, Katlama C, Fätkenheuer G, Lundgren J D, Mocroft A, Mocroft A (2011), A comparison of the long-term durability of nevirapine, efavirenz and lopinavir in routine clinical practice in Europe: a EuroSIDA study., in HIV medicine, 12(5), 259-68.
An interdisciplinary HIV-adherence program combining motivational interviewing and electronic antiretroviral drug monitoring.
Krummenacher Isabelle, Cavassini Matthias, Bugnon Olivier, Schneider Marie P (2011), An interdisciplinary HIV-adherence program combining motivational interviewing and electronic antiretroviral drug monitoring., in AIDS care, 23(5), 550-61.
Effect of transmitted drug resistance on virological and immunological response to initial combination antiretroviral therapy for HIV (EuroCoord-CHAIN joint project): a European multicohort study.
Wittkop Linda, Günthard Huldrych F, de Wolf Frank, Dunn David, Cozzi-Lepri Alessandro, de Luca Andrea, Kücherer Claudia, Obel Niels, von Wyl Viktor, Masquelier Bernard, Stephan Christoph, Torti Carlo, Antinori Andrea, García Federico, Judd Ali, Porter Kholoud, Thiébaut Rodolphe, Castro Hannah, van Sighem Ard I, Colin Céline, Kjaer Jesper, Lundgren Jens D, Paredes Roger, Pozniak Anton, Clotet Bonaventura, Phillips Andrew, Pillay Deenan, Chêne Geneviève, Chêne Geneviève (2011), Effect of transmitted drug resistance on virological and immunological response to initial combination antiretroviral therapy for HIV (EuroCoord-CHAIN joint project): a European multicohort study., in The Lancet. Infectious diseases, 11(5), 363-71.
Efficacy, tolerability and risk factors for virological failure of darunavir-based therapy for treatment-experienced HIV-infected patients: the Swiss HIV Cohort Study.
Young J, Scherrer A U, Günthard H F, Opravil M, Yerly S, Böni J, Rickenbach M, Fux C A, Cavassini M, Bernasconi E, Vernazza P, Hirschel B, Battegay M, Bucher H C, Bucher H C (2011), Efficacy, tolerability and risk factors for virological failure of darunavir-based therapy for treatment-experienced HIV-infected patients: the Swiss HIV Cohort Study., in HIV medicine, 12(5), 299-307.
Estimating the net contribution of interleukin-28B variation to spontaneous hepatitis C virus clearance.
di Iulio Julia, Ciuffi Angela, Fitzmaurice Karen, Kelleher Dermot, Rotger Margalida, Fellay Jacques, Martinez Raquel, Pulit Sara, Furrer Hansjakob, Günthard Huldrych F, Battegay Manuel, Bernasconi Enos, Schmid Patrick, Hirschel Bernard, Barnes Eleanor, Klenerman Paul, Telenti Amalio, Rauch Andri, Rauch Andri (2011), Estimating the net contribution of interleukin-28B variation to spontaneous hepatitis C virus clearance., in Hepatology (Baltimore, Md.), 53(5), 1446-54.
Lipid and lipoprotein profile in HIV-infected patients treated with lopinavir/ritonavir as a component of the first combination antiretroviral therapy.
Magenta L, Dell-Kuster S, Richter W O, Young J, Hasse B, Flepp M, Hirschel B, Vernazza P, Evison J, Cavassini M, Decosterd L A, Bucher H C, Bernasconi E, Bernasconi E (2011), Lipid and lipoprotein profile in HIV-infected patients treated with lopinavir/ritonavir as a component of the first combination antiretroviral therapy., in AIDS research and human retroviruses, 27(5), 525-33.
Trends over time of virological and immunological characteristics in the Swiss HIV Cohort Study.
Ledergerber B, Cavassini M, Battegay M, Bernasconi E, Vernazza P, Hirschel B, Furrer H, Rickenbach M, Weber R, Weber R (2011), Trends over time of virological and immunological characteristics in the Swiss HIV Cohort Study., in HIV medicine, 12(5), 279-88.
Decline of CD4⁺ T-cell count before start of therapy and immunological response to treatment in antiretroviral-naive individuals.
Mussini Cristina, Cossarizza Andrea, Sabin Caroline, Babiker Abdel, De Luca Andrea, Bucher Heiner C, Fisher Martin, Rezza Giovanni, Porter Kholoud, Dorrucci Maria, Dorrucci Maria (2011), Decline of CD4⁺ T-cell count before start of therapy and immunological response to treatment in antiretroviral-naive individuals., in AIDS (London, England), 25(8), 1041-9.
The hepatitis C epidemic among HIV-positive MSM: incidence estimates from 1990 to 2007.
van der Helm Jannie J, Prins Maria, del Amo Julia, Bucher Heiner C, Chêne Geneviève, Dorrucci Maria, Gill John, Hamouda Osamah, Sannes Mette, Porter Kholoud, Geskus Ronald B, Geskus Ronald B (2011), The hepatitis C epidemic among HIV-positive MSM: incidence estimates from 1990 to 2007., in AIDS (London, England), 25(8), 1083-91.
Risk of triple-class virological failure in children with HIV: a retrospective cohort study.
Pursuing Later Treatment Options II (PLATO II) project team for the Collaboration of Observational HIV Epidemiological Research Europe (COHERE), Castro Hannah, Judd Ali, Gibb Diana M, Butler Karina, Lodwick Rebecca K, van Sighem Ard, Ramos Jose T, Warsawski Josiane, Thorne Claire, Noguera-Julian Antoni, Obel Niels, Costagliola Dominique, Tookey Pat A, Colin Céline, Kjaer Jesper, Grarup Jesper, Chene Genevieve, Phillips Andrew (2011), Risk of triple-class virological failure in children with HIV: a retrospective cohort study., in Lancet (London, England), 377(9777), 1580-7.
Antiretroviral therapy during pregnancy and premature birth: analysis of Swiss data.
Rudin C, Spaenhauer A, Keiser O, Rickenbach M, Kind C, Aebi-Popp K, Brinkhof M W G, Brinkhof M W G, Brinkhof M W G (2011), Antiretroviral therapy during pregnancy and premature birth: analysis of Swiss data., in HIV medicine, 12(4), 228-35.
First-line antiretroviral therapy with a protease inhibitor versus non-nucleoside reverse transcriptase inhibitor and switch at higher versus low viral load in HIV-infected children: an open-label, randomised phase 2/3 trial.
PENPACT-1 (PENTA 9/PACTG 390) Study Team, Babiker Abdel, Castro nee Green Hannah, Compagnucci Alexandra, Fiscus Susan, Giaquinto Carlo, Gibb Diana M, Harper Lynda, Harrison Linda, Hughes Michael, McKinney Ross, Melvin Ann, Mofenson Lynne, Saidi Yacine, Smith M Elizabeth, Tudor-Williams Gareth, Walker A Sarah (2011), First-line antiretroviral therapy with a protease inhibitor versus non-nucleoside reverse transcriptase inhibitor and switch at higher versus low viral load in HIV-infected children: an open-label, randomised phase 2/3 trial., in The Lancet. Infectious diseases, 11(4), 273-83.
Viral suppression rates in salvage treatment with raltegravir improved with the administration of genotypic partially active or inactive nucleoside/tide reverse transcriptase inhibitors
Scherrer Alexandra U, von Wyl Viktor, Böni Jürg, Yerly Sabine, Klimkait Thomas, Bürgisser Philippe, Garzoni Christian, Hirschel Bernard, Cavassini Matthias, Battegay Manuel, Vernazza Pietro L, Bernasconi Enos, Ledergerber Bruno, Günthard Huldrych F, Günthard Huldrych F (2011), Viral suppression rates in salvage treatment with raltegravir improved with the administration of genotypic partially active or inactive nucleoside/tide reverse transcriptase inhibitors, in Journal of acquired immune deficiency syndromes (1999), 57(1), 24-31.
Differential microRNA regulation of HLA-C expression and its association with HIV control.
Kulkarni Smita, Savan Ram, Qi Ying, Gao Xiaojiang, Yuki Yuko, Bass Sara E, Martin Maureen P, Hunt Peter, Deeks Steven G, Telenti Amalio, Pereyra Florencia, Goldstein David, Wolinsky Steven, Walker Bruce, Young Howard A, Carrington Mary (2011), Differential microRNA regulation of HLA-C expression and its association with HIV control., in Nature, 472(7344), 495-8.
When to initiate combined antiretroviral therapy to reduce mortality and AIDS-defining illness in HIV-infected persons in developed countries: an observational study.
HIV-CAUSAL Collaboration, Cain Lauren E, Logan Roger, Robins James M, Sterne Jonathan A C, Sabin Caroline, Bansi Loveleen, Justice Amy, Goulet Joseph, van Sighem Ard, de Wolf Frank, Bucher Heiner C, von Wyl Viktor, Esteve Anna, Casabona Jordi, del Amo Julia, Moreno Santiago, Seng Remonie, Meyer Laurence, Perez-Hoyos Santiago, Muga Roberto, Lodi Sara, Lanoy Emilie, Costagliola Dominique, Hernan Miguel A (2011), When to initiate combined antiretroviral therapy to reduce mortality and AIDS-defining illness in HIV-infected persons in developed countries: an observational study., in Annals of internal medicine, 154(8), 509-15.
Development and validation of decision rules to guide frequency of monitoring CD4 cell count in HIV-1 infection before starting antiretroviral therapy.
Buclin Thierry, Telenti Amalio, Perera Rafael, Csajka Chantal, Furrer Hansjakob, Aronson Jeffrey K, Glasziou Paul P (2011), Development and validation of decision rules to guide frequency of monitoring CD4 cell count in HIV-1 infection before starting antiretroviral therapy., in PloS one, 6(4), 18578-18578.
Predictors for the emergence of the 2 multi-nucleoside/nucleotide resistance mutations 69 insertion and Q151M and their impact on clinical outcome in the Swiss HIV cohort study.
Scherrer Alexandra U, von Wyl Viktor, Joos Beda, Klimkait Thomas, Bürgisser Philippe, Yerly Sabine, Böni Jürg, Ledergerber Bruno, Günthard Huldrych F, Günthard Huldrych F (2011), Predictors for the emergence of the 2 multi-nucleoside/nucleotide resistance mutations 69 insertion and Q151M and their impact on clinical outcome in the Swiss HIV cohort study., in The Journal of infectious diseases, 203(6), 791-7.
No longitudinal mitochondrial DNA sequence changes in HIV-infected individuals with and without lipoatrophy.
Ortiz Millán, Poloni Estella S, Furrer Hansjakob, Kovari Helen, Martinez Raquel, Arnedo Mireia, Elzi Luigia, Bernasconi Enos, Vernazza Pietro, Hirschel Bernard, Cavassini Matthias, Ledergerber Bruno, Günthard Huldrych F, Telenti Amalio, Tarr Philip E, Tarr Philip E (2011), No longitudinal mitochondrial DNA sequence changes in HIV-infected individuals with and without lipoatrophy., in The Journal of infectious diseases, 203(5), 620-4.
Interruptions of cART limits CD4 T-cell recovery and increases the risk for opportunistic complications and death.
Kaufmann Gilbert R, Elzi Luigia, Weber Rainer, Furrer Hansjakob, Giulieri Stefano, Vernazza Pietro, Bernasconi Enos, Hirschel Bernard, Battegay Manuel, Battegay Manuel (2011), Interruptions of cART limits CD4 T-cell recovery and increases the risk for opportunistic complications and death., in AIDS (London, England), 25(4), 441-51.
Ambiguous Nucleotide Calls From Population-based Sequencing of HIV-1 are a Marker for Viral Diversity and the Age of Infection
Kouyos Roger D., von Wyl Viktor, Yerly Sabine, Böni Jürg, Rieder Philip, Joos Beda, Taffé Patrick, Shah Cyril, Bürgisser Philippe, Klimkait Thomas, Weber Rainer, Hirschel Bernard, Cavassini Matthias, Rauch Andri, Battegay Manuel, Vernazza Pietro L., Bernasconi Enos, Ledergerber Bruno, Bonhoeffer Sebastian, Günthard Huldrych F. (2011), Ambiguous Nucleotide Calls From Population-based Sequencing of HIV-1 are a Marker for Viral Diversity and the Age of Infection, in Clinical Infectious Diseases, 52(4), 532-539.
Replicative phenotyping adds value to genotypic resistance testing in heavily pre-treated HIV-infected individuals--the Swiss HIV Cohort Study.
Fehr Jan, Glass Tracy R, Louvel Séverine, Hamy François, Hirsch Hans H, von Wyl Viktor, Böni Jürg, Yerly Sabine, Bürgisser Philippe, Cavassini Matthias, Fux Christoph A, Hirschel Bernard, Vernazza Pietro, Martinetti Gladys, Bernasconi Enos, Günthard Huldrych F, Battegay Manuel, Bucher Heiner C, Klimkait Thomas, Klimkait Thomas (2011), Replicative phenotyping adds value to genotypic resistance testing in heavily pre-treated HIV-infected individuals--the Swiss HIV Cohort Study., in Journal of translational medicine, 9, 14-14.
Association of pharmacogenetic markers with premature discontinuation of first-line anti-HIV therapy: an observational cohort study.
Lubomirov Rubin, Colombo Sara, di Iulio Julia, Ledergerber Bruno, Martinez Raquel, Cavassini Matthias, Hirschel Bernard, Bernasconi Enos, Elzi Luigia, Vernazza Pietro, Furrer Hansjakob, Günthard Huldrych F, Telenti Amalio, Telenti Amalio (2011), Association of pharmacogenetic markers with premature discontinuation of first-line anti-HIV therapy: an observational cohort study., in The Journal of infectious diseases, 203(2), 246-57.
A randomized crossover study to compare efavirenz and etravirine treatment.
Nguyen Alain, Calmy Alexandra, Delhumeau Cécile, Mercier Isabelle K, Cavassini Matthias, Fayet-Mello Aurélie, Elzi Luigia, Genné Daniel, Rauch Andri, Bernasconi Enos, Hirschel Bernard, Hirschel Bernard (2011), A randomized crossover study to compare efavirenz and etravirine treatment., in AIDS (London, England), 25(1), 57-63.

Collaboration

Group / person Country
Types of collaboration
MITOC Germany (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
SHCS collaborations Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
HIV CAUSAL United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
B. Vidondo, FOPH, Bern Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
EuroSIDA Denmark (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
NEAT Italy (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
HIV TB Denmark (Europe)
- Publication
C. Nordt, Psych. Universitätsklinik (PUK) Zürich Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Plato II Great Britain and Northern Ireland (Europe)
- Publication
EuroCHAVI Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Cascade Great Britain and Northern Ireland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
HIV monitoring Foundation, Amsterdam Netherlands (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
A. Spörri, ISPM, Bern Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Cohere Denmark (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
L. Held, Biostatistik, UZH Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
General Hospital Corporation, Masschusetts General Hospital, United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
S. Franceschi, IARC, Lyon, France France (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
J. McCarthy, Duke University, Durham, USA United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
P. Klenermann, Nuffield Dept of Int. Medicine, Univ. of Oxford Great Britain and Northern Ireland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
PENTA/ECS Italy (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
R. Gupta, Univ. College, London ,UK Great Britain and Northern Ireland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
DAD Denmark (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Penta-EICG Italy (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
ART-CC Great Britain and Northern Ireland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
J. Montaner, British Colombia Centre for Excellence in HIV-AIDS,Canada Canada (North America)
- in-depth/constructive exchanges on approaches, methods or results
- Publication

Associated projects

Number Title Start Funding scheme
127631 Contribution of multiple genetic variants, identified in genome-wide association studies, to coronary artery disease in HIV-infected individuals 01.12.2009 Project funding (special)
125441 Molecular and clinical epidemiology of tuberculosis in Switzerland: Studies of populations infected and not infected with HIV 01.04.2009 Project funding (special)
108787 Swiss HIV Cohort Study 01.04.2006 Cohort Studies Large
116862 Impact of HIV and antiretroviral therapy on Hepatitis C virus (HCV) evolution and on HCV-specific cellular immunity 01.06.2007 Project funding (special)
112594 HIV-1 drug resistance in the swiss HIV cohort study: epidemiology and impact on the management of HIV infected patients 01.05.2006 Project funding (special)
114006 Monotherapy in Switzerland and Thailand (MOST-cohort) 01.10.2006 Project funding (special)
124943 Pharmacocinétique de population, pharmacogénétique, et profils métaboliques de la thérapie anti-HIV 01.04.2009 Project funding (special)
110012 Host genetic and genomic determinants of susceptibility to HIV-1 01.11.2005 Project funding (Div. I-III)
144209 Dynamics of atherosclerosis progression in HIV-infected and HIV-uninfected persons - a longitudinal study using coronary computed tomography angiography 01.07.2013 Project funding (special)
149792 Opportunistic Infections in the Era of combination ART: Collaborative Analysis of European HIV Cohort Studies 01.11.2013 Project funding (special)
120793 Minority quasispecies of drug-resistant HIV-1: Emergence, transmission, dynamics, and clinical relevance in acute and chronic HIV-1 infection 01.11.2008 Project funding (special)
130865 HIV-1 Transmission in Switzerland: Long term-molecular epidemiology and biological properties of transmitted viruses 01.11.2010 Project funding (special)
127017 HIV-1 whole-genome quasispecies analysis by ultra-deep sequencing and computational haplotype inference to determine the mechanisms of drug resistance development 01.01.2010 Interdisciplinary projects
103560 Cost-effectiveness of genotypic and phenotypic antiretroviral resistance testing in HIV infected patients 01.07.2004 Project funding (special)
112655 Managing variability in HIV therapy: integration of pharmacogenetics, pharmacokinetics and pharmacodynamics of antiretroviral drugs 01.04.2006 Project funding (special)
177499 Swiss HIV Cohort Study (SHCS) 01.01.2018 Cohort Studies Large
148522 Swiss HIV Cohort Study (SHCS) 01.01.2014 Cohort Studies Large

Abstract

The Swiss HIV Cohort Study (SHCS), established in 1988, is an ongoing clinic-based cohort of cumulatively 16'400 HIV-1 infected adults. Socio-demographical, clinical and laboratory information as well as biological samples are collected semi-annually and subjected to stringent quality control procedures. The size and prospective longitudinal design of the cohort provide researchers invaluable opportunities to carry out research projects. This would not be possible outside a nation wide project : The findings from the many different scientific areas cover a very broad spectrum of topics such as basic science, clinical epidemiology, both viral and host genetics. The reader is referred to the enclosed list of publications related to 2000-June 2010, the extensive list is enclosed. The success of the SHCS over the last decade can primarily be attributed to nested research projects allowing for timely basic and clinical research based upon a carefully maintained high-quality infrastructure and the openness to embark on new themes or collaborations where needed.
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