Polyparasitism; Malaria; Schistosomiasis; Soil-transmitted helminthiasis; Geographical information system; Bayesian geostatistical modelling; Morbidity; Quality of life; Co-morbidity; Bayesian geostatistics; Disability weights
Hürlimann Eveline, Houngbedji Clarisse A, N'Dri Prisca B, Bänninger Dominique, Coulibaly Jean T, Yap Peiling, Silué Kigbafori D, N'Goran Eliézer K, Raso Giovanna, Utzinger Jürg (2014), Effect of deworming on school-aged children's physical fitness, cognition and clinical parameters in a malaria-helminth co-endemic area of Côte d'Ivoire., in BMC infectious diseases
, 14(1), 411-411.
Yapi Richard B, Hürlimann Eveline, Houngbedji Clarisse A, Ndri Prisca B, Silué Kigbafori D, Soro Gotianwa, Kouamé Ferdinand N, Vounatsou Penelope, Fürst Thomas, N'Goran Eliézer K, Utzinger Jürg, Raso Giovanna (2014), Infection and co-infection with helminths and Plasmodium among school children in Côte d'Ivoire: results from a National Cross-Sectional Survey., in PLoS neglected tropical diseases
, 8(6), 2913-2913.
Ouattara Allassane F, Dagnogo Mamadou, Olliaro Piero L, Raso Giovanna, Tanner Marcel, Utzinger Jürg, Koudou Benjamin G (2014), Plasmodium falciparum infection and clinical indicators in relation to net coverage in central Côte d'Ivoire., in Parasites & vectors
, 7(1), 306-306.
Hürlimann Eveline, Yapi Richard B, Houngbedji Clarisse A, Schmidlin Thomas, Kouadio Bernadette A, Silué Kigbafori D, Ouattara Mamadou, N'Goran Eliézer K, Utzinger Jürg, Raso Giovanna (2014), The epidemiology of polyparasitism and implications for morbidity in two rural communities of Côte d'Ivoire., in Parasites & vectors
, 7, 81-81.
Ouattara Allassane F, Dagnogo Mamadou, Constant Edi A V, Koné Moussa, Raso Giovanna, Tanner Marcel, Olliaro Piero L, Utzinger Jürg, Koudou Benjamin G (2014), Transmission of malaria in relation to distribution and coverage of long-lasting insecticidal nets in central Côte d'Ivoire., in Malaria journal
, 13, 109-109.
Schmidlin Thomas, Hürlimann Eveline, Silué Kigbafori D, Yapi Richard B, Houngbedji Clarisse, Kouadio Bernadette A, Acka-Douabélé Cinthia A, Kouassi Dongo, Ouattara Mamadou, Zouzou Fabien, Bonfoh Bassirou, N'Goran Eliézer K, Utzinger Jürg, Raso Giovanna (2013), Effects of hygiene and defecation behavior on helminths and intestinal protozoa infections in Taabo, Côte d'Ivoire., in PloS one
, 8(6), 65722-65722.
Raso Giovanna, Schur Nadine, Utzinger Jürg, Koudou Benjamin G, Tchicaya Emile S, Rohner Fabian, N'goran Eliézer K, Silué Kigbafori D, Matthys Barbara, Assi Serge, Tanner Marcel, Vounatsou Penelope (2012), Mapping malaria risk among children in Cote d'Ivoire using Bayesian geo-statistical models., in Malaria journal
, 11(1), 160-160.
Comoé Colombe Coffie, Ouattara Allassane F, Raso Giovanna, Tanner Marcel, Utzinger Jürg, Koudou Benjamin G (2012), Willingness to use a rapid diagnostic test for malaria in a rural area of central Côte d'Ivoire., in BMC public health
, 12, 1089-1089.
Ouattara Allassane F, Raso Giovanna, Edi Constant VA, Utzinger Jürg, Tanner Marcel, Dagnogo Mamadou, Koudou Benjamin G (2011), Malaria knowledge and long-lasting insecticidal net use in rural communities of central Côte d’Ivoire, in Malaria Journal
, 10, 288-12.
Bonfoh Bassirou, Raso Giovanna, Koné Inza, Dao Daouda, Girardin Olivier, Cissé Gueladio, Zinsstag Jakob, Utzinger Jürg, Tanner Marcel (2011), Research in a war zone, in Nature
, 474(7353), 569-571.
Balen Julie, Raso Giovanna, Li Yue-Sheng, Zhao Zheng-Yuan, Yuan Li-Ping, Williams Gail M, Luo Xin-Song, Shi Meng-Zhi, Yu Xin-Ling, Utzinger Jürg, McManus Donald P (2011), Risk factors for helminth infections in a rural and a peri-urban setting of the Dongting Lake area, People's Republic of China., in International journal for parasitology
, 41(11), 1165-73.
Background: In developing countries, the spatial and temporal distribution of different parasitic infections often overlaps, and hence polyparasitism is a common phenomenon. Whilst most research has concentrated on single species parasite infections, there is growing interest to further elucidate the issue of polyparasitism. A deeper understanding of polyparasitism is not only relevant from a fundamental point of view, but also to harness programmatic similarities for integrated, cost-effective and sustainable control. At present, morbidity implications of polyparasitism are poorly understood, as are synergistic or antagonistic effects of polyparasite infections and consequences for control. For example, some studies suggest that the co-occurrence of helminths and Plasmodium might worsen the clinical outcome of malaria, whereas no interaction between these parasites was found in other studies.Hypotheses: (1) Polyparasitism is pervasive among school-aged children and entire rural communities of Côte d’Ivoire and the spatial and temporal distribution of polyparasitic infections is governed by an array of determinants, including behavioural, climatic, environmental, intervention-related and socio-economic factors. We conjecture that the importance of each factor differs depending on the spatial scale. (2) The effect resulting from an interaction between parasite species on morbidity and self-rated quality of life may be additive or multiplicative. Depending on the parasite interaction and the intensity of infection, synergistic or antagonistic effects may prevail between parasite species.Aim: To generate new knowledge on the spatial distribution and burden of polyparasitism in Côte d’Ivoire, placing emphasis on malaria and intestinal helminth infections at different spatial scales, to investigate interactions between parasites and how these interactions affect morbidity and self-rated quality of life, including the assessment of age-specific disability weights.Methods: We will carry out cross-sectional surveys, combining clinical, parasitological and questionnaire surveys to gather the necessary data in selected schools and entire communities, across Côte d’Ivoire. Remote sensing, geographical information system and Bayesian geostatistical modelling will be used to analyse spatial determinants of polyparasitism at community and regional level and to produce risk maps for the spatial distribution of co-infections. We will use statistical analyses to measure the association of morbidity and self-rated quality of life with polyparasitism. Interactions between different parasite species will be determined, and the effects of infection intensity on anaemia, organ pathology, nutritional status and self-reported morbidity and quality of life revealed. Age-specific disability weights for parasitic infections will be determined.Expected results and significance: A comprehensive, spatially-explicit database on polyparasitism, morbidity and self-rated quality of life will be generated for Côte d’Ivoire and probed for parasite associations and impact of single- and multiple species infections on morbidity and self-rated quality of life. This knowledge will deepen our understanding of parasite-parasite interactions at individual and community level and provides a basis for the control of polyparasitism in Côte d’Ivoire and elsewhere.