Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Dynamic Nuclear Polarization; Cardiovascular Magnetic Resonance; Sparse Sampling; Spatiotemporal Correlation; Transform Coding; Absolute Quantification; Ischemic Heart Disease; Reperfusion Injury; Coronary heart disease; Cardiac function; Perfusion; Metabolism; Hyperpolarized Magnetic Resonance
Knobloch Verena, Binter Christian, Kurtcuoglu Vartan, Kozerke Sebastian (2014), Arterial, venous, and cerebrospinal fluid flow: simultaneous assessment with Bayesian multipoint velocity-encoded MR imaging., in Radiology
, 270(2), 566-73.
Motwani Manish, Maredia Neil, Fairbairn Timothy A, Kozerke Sebastian, Greenwood John P, Plein Sven (2014), Assessment of ischaemic burden in angiographic three-vessel coronary artery disease with high-resolution myocardial perfusion cardiovascular magnetic resonance imaging., in European heart journal cardiovascular Imaging
Gotschy Alexander, Binter Christian, Niemann Markus, Alkadhi Hatem, Kana Veronika, Czerny Martin, Tanner Felix C, Kozerke Sebastian, Manka Robert (2014), Multimodal functional evaluation of severe kinking of an ascending aortic prosthesis in a patient with embolic stroke., in European heart journal
Motwani Manish, Kidambi Ananth, Sourbron Steven, Fairbairn Timothy A, Uddin Akhlaque, Kozerke Sebastian, Greenwood John P, Plein Sven (2014), Quantitative three-dimensional cardiovascular magnetic resonance myocardial perfusion imaging in systole and diastole., in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Ma
, 16, 19-19.
Weiss Kilian, Sigfridsson Andreas, Wissmann Lukas, Busch Julia, Batel Michael, Krajewski Marcin, Ernst Matthias, Kozerke Sebastian (2013), Accelerating hyperpolarized metabolic imaging of the heart by exploiting spatiotemporal correlations., in NMR in biomedicine
, 26(11), 1380-6.
Motwani Manish, Jogiya Roy, Kozerke Sebastian, Greenwood John P, Plein Sven (2013), Advanced cardiovascular magnetic resonance myocardial perfusion imaging: high-spatial resolution versus 3-dimensional whole-heart coverage., in Circulation. Cardiovascular imaging
, 6(2), 339-48.
Weiss Kilian, Martini Nicola, Boesiger Peter, Kozerke Sebastian (2013), Cardiac proton spectroscopy using large coil arrays., in NMR in biomedicine
, 26(3), 276-84.
Weiss Kilian, Summermatter Severin, Stoeck Christian T, Kozerke Sebastian (2013), Compensation of signal loss due to cardiac motion in point-resolved spectroscopy of the heart., in Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine /
Jogiya Roy, Makowski Markus, Phinikaridou Alkystsis, Patel Ashish S, Jansen Christian, Zarinabad Nelly, Chiribiri Amedeo, Botnar Rene, Nagel Eike, Kozerke Sebastian, Plein Sven (2013), Hyperemic stress myocardial perfusion cardiovascular magnetic resonance in mice at 3 Tesla: initial experience and validation against microspheres., in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Ma
, 15(1), 62-62.
Schmidt Johannes F M, Wissmann Lukas, Manka Robert, Kozerke Sebastian (2013), Iterative k-t principal component analysis with nonrigid motion correction for dynamic three-dimensional cardiac perfusion imaging., in Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine /
Manka Robert, Busch Julia, Crelier Gerard, Lüscher Thomas F, Kozerke Sebastian (2013), Pre- and post-operative assessment of valvular and aortic flow using 4D flow magnetic resonance imaging., in European heart journal
Busch Julia, Giese Daniel, Wissmann Lukas, Kozerke Sebastian (2013), Reconstruction of divergence-free velocity fields from cine 3D phase-contrast flow measurements., in Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine /
, 69(1), 200-10.
Manka Robert, Kozerke Sebastian, Rutz Andrea K, Stoeck Christian T, Boesiger Peter, Schwitter Juerg (2012), A CMR study of the effects of tissue edema and necrosis on left ventricular dyssynchrony in acute myocardial infarction: implications for cardiac resynchronization therapy., in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Ma
, 14, 47-47.
Batel Michael, Krajewski Marcin, Weiss Kilian, With Oliver, Däpp Alexander, Hunkeler Andreas, Gimersky Martin, Pruessmann Klaas P, Boesiger Peter, Meier Beat H, Kozerke Sebastian, Ernst Matthias (2012), A multi-sample 94GHz dissolution dynamic-nuclear-polarization system., in Journal of magnetic resonance (San Diego, Calif. : 1997)
, 214(1), 166-174.
Weiss K, Mariotti E, Hill DK, Orton MR, Dunn JT, Medina RA, Southworth R, Kozerke S, Eykyn TR (2012), Developing Hyperpolarized 13C Spectroscopy and Imaging for Metabolic Studies in the Isolated Perfused Rat Heart, in Applied Magnetic Resonance
, 43(1-2), 275-288.
Batel M, Krajewski M, Däpp A, Hunkeler A, Meier BH, Kozerke S, Ernst M (2012), Dissolution dynamic nuclear polarization efficiency enhanced by Hartmann-Hahn cross polarization, in Chemical Physics Letters
, 554, 72-76.
Motwani Manish, Maredia Neil, Fairbairn Timothy A, Kozerke Sebastian, Radjenovic Aleksandra, Greenwood John P, Plein Sven (2012), High-resolution versus standard-resolution cardiovascular MR myocardial perfusion imaging for the detection of coronary artery disease., in Circulation. Cardiovascular imaging
, 5(3), 306-13.
Weiss Kilian, Martini Nicola, Boesiger Peter, Kozerke Sebastian (2012), Metabolic MR imaging of regional triglyceride and creatine content in the human heart., in Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine /
, 68(6), 1696-704.
Tsao Jeffrey, Kozerke Sebastian (2012), MRI temporal acceleration techniques., in Journal of magnetic resonance imaging : JMRI
, 36(3), 543-60.
Knobloch Verena, Boesiger Peter, Kozerke Sebastian (2012), Sparsity transform k-t principal component analysis for accelerating cine three-dimensional flow measurements., in Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine /
Stoeck Christian T, Manka Robert, Boesiger Peter, Kozerke Sebastian (2012), Undersampled Cine 3D tagging for rapid assessment of cardiac motion., in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Ma
, 14, 60-60.
Jogiya Roy, Kozerke Sebastian, Morton Geraint, De Silva Kalpa, Redwood Simon, Perera Divaka, Nagel Eike, Plein Sven (2012), Validation of dynamic 3-dimensional whole heart magnetic resonance myocardial perfusion imaging against fractional flow reserve for the detection of significant coronary artery disease., in Journal of the American College of Cardiology
, 60(8), 756-65.
Manka Robert, Paetsch Ingo, Kozerke Sebastian, Moccetti Marco, Hoffmann Rainer, Schroeder Joerg, Reith Sebastian, Schnackenburg Bernhard, Gaemperli Oliver, Wissmann Lukas, Wyss Christophe A, Kaufmann Philipp A, Corti Roberto, Boesiger Peter, Marx Nikolaus, Lüscher Thomas F, Jahnke Cosima (2012), Whole-heart dynamic three-dimensional magnetic resonance perfusion imaging for the detection of coronary artery disease defined by fractional flow reserve: determination of volumetric myocardial ischaemic burden and coronary lesion location., in European heart journal
, 33(16), 2016-24.
Manka Robert, Kuhn Felix P, Kuest Silke M, Gaemperli Oliver, Kozerke Sebastian, Kaufmann Philipp A (2011), Hybrid cardiac magnetic resonance/computed tomographic imaging: first fusion of three-dimensional magnetic resonance perfusion and low-dose coronary computed tomographic angiography., in European Heart Journal
, 32(21), 2625-2625.
Despite significant progress in patient care coronary heart disease (CHD) remains the leading cause of death worldwide. Considerable efforts have been directed towards timely detection and interventions in patients with CHD. Management decisions are increasingly based on functional assessment reflecting the growing evidence that intervention in CHD convey no benefit or may even cause harm unless directed to viable and ischemic myocardium. The role of diagnostic procedures including Cardiovascular Magnetic Resonance (CMR) imaging is therefore rapidly increasing. Today, the clinical value of CMR for the assessment of global ventricular function and the detection of myocardial scar has been well established. Besides its place in a clinical environment CMR has also become invaluable in a pre-clinical setting and its potential for translational research within a “bench to bedside” strategy has started to unfold.Advances in magnetic resonance imaging methods have been and continue to be key drivers for the expanding role of CMR as a diagnostic tool. Seminal work in parallel imaging and prior knowledge-driven methods has successfully relaxed the hitherto tight interrelation between spatiotemporal resolution and scan time. Moreover, the advent of dissolution Dynamic Nuclear Polarization (DNP) methods has opened up a new window for observing metabolic processes in the in-vivo heart in real-time. In this context the perspective of obtaining detailed quantitative measures of perfusion, substrate metabolism and contractile function of the entire heart with a single non-invasive imaging modality is highly appealing in both the pre-clinical and clinical realms.Perfusion, metabolism and contractile function are tightly coupled and well regulated within bounds. In ischemia, continuous supply of oxygen is reduced or disrupted and the fine balance of metabolic substrates utilization is disturbed. In the event of persistent ischemia, reperfusion intervention can restore myocardial blood supply and hence potentially recovers contractile function. It has, however, been recognized that reperfusion intervention can cause damage to functioning myocardium and the controversy about the underlying mechanisms of reperfusion injury and its treatment is still ongoing. To this end, an integrated non-invasive approach to quantifying perfusion, metabolism and contractile function can help addressing this debate. Current CMR methods for the assessment of perfusion, function and metabolism as available on standard imaging systems lack sufficient scan efficiency and sensitivity and often provide only semi-quantitative information. The limited scan efficiency restricts spatial-temporal resolution which is particularly critical when imaging transient signals in bolus perfusion and hyperpolarized metabolic imaging. Quantification methods have been proposed for conventional CMR perfusion and motion mapping methods, yet their analysis and adaptation to highly-accelerated methods remains to be accomplished.The objectives of the present project are to develop and validate highly-accelerated and quantitative CMR imaging methods for assessing perfusion, metabolism and contractile function of the ischemic heart. In addressing the limited scan efficiency, prior knowledge driven methods will be developed to provide highly-accelerated imaging of perfusion and function of the beating heart. Owing to the significant increase in scan efficiency we will also be able to translate this technology to the small animal heart which will permit bolus perfusion and functional imaging at high heart rates and during ischemia-reperfusion interventions. Starting from the accelerated imaging technology developed for perfusion imaging, two- and three-dimensional methods for spatially resolved metabolic imaging of hyperpolarized compounds will be implemented. This project is based on our recently developed multi-sample DNP system for carbon polarization. This system is designed to provide up to six bolus injections for repeated assessment of metabolic information during interventions in the animal heart. To validate and assess clinical utility of the methods we aim to apply the perfusion and contractile imaging methods to patients with CHD together with national and international partners.The overall program consists of four work packages exploiting the power of accelerated imaging methods for assessing perfusion, metabolism and function of the ischemic heart:• Development of highly accelerated CMR imaging methods for perfusion, metabolic and tissue tagged imaging including- extension of the k-t imaging framework to constrain temporal signal evolution and spatial confinement- evaluation of reconstruction error and noise properties • Analysis and adaptation of quantitative processing algorithms comprising- definition of suitable deconvolution strategies for quantitative perfusion and metabolic imaging- introduction of joint modulus and phase processing for myocardial tagging data• Study of perfusion, metabolism and function of ischemia-reperfusion in animal model including- implementation of accelerated quantitative perfusion, metabolic and contractile imaging on animal imager- feasibility study of quantitative perfusion, metabolism and motion in occlusion/reperfusion scenarios • Application of accelerated three-dimensional perfusion and motion quantification in patients involving- perfusion and functional imaging in patients with chronic CHD undergoing revascularization procedures- clinical studies of ischemia-reperfusion injury in patients with acute myocardial infarctionThe methodological work proposed herein aims to develop a single non-invasive tool to study the correlation of perfusion, metabolism and contraction in a quantitative manner with high spatial and temporal resolution. The project addresses two main drawbacks of current CMR methods in preclinical and clinical research - scan efficiency and sensitivity. Scan efficiency plays a pivotal role in cardiac applications since a moving target is imaged. Moreover, contrast enhanced perfusion imaging as well as hyperpolarization methods provide a transient signal demanding very efficient data sampling. Hyperpolarization methods offer a new approach to boost sensitivity for metabolic imaging. Even though this method is currently only applicable in a preclinical setting, its translation into humans is anticipated in the near future. In its entirety a non-invasive single-modality imaging approach for quantitative assessment of perfusion, metabolism and function offers intriguing possibilities to study the correlation of energy supply, conversion and work of the heart under normal and ischemic conditions.