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Probe for High-Speed Magic Angle Spinning at 800 MHz

English title Probe for High-Speed Magic Angle Spinning at 800 MHz
Applicant Bodenhausen Geoffrey
Number 128682
Funding scheme R'EQUIP
Research institution Laboratoire de résonance magnétique biomoléculaire EPFL - SB - ISIC - LRMB
Institution of higher education EPF Lausanne - EPFL
Main discipline Physical Chemistry
Start/End 01.04.2010 - 31.03.2012
Approved amount 67'758.00
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Keywords (9)

Solid-State Nuclear Magnetic Resonance; Magic Angle Spinning; Decoupling of Magnetic Interactions; Recoupling of Magnetic Interactions; Nitrogen-14 Detection; Molecular Structure; Nuclear Magnetic Resonance; Solid State; Spectral Resolution

Lay Summary (English)

Lead
Lay summary
Resolving molecular structures via nuclear magnetic resonance (NMR) spectroscopy of solid-state samples relies on the identification of signals from different molecular sites. Finding a one-to-one correspondence between magnetic nuclei in the sample and signals in the NMR spectrum is often rendered difficult by the width of the observed lines. A continuous rotation (spinning) of the sample, placed at a certain angle with the main magnetic field ('magic angle'), during observation, is known to narrow spectral lines and facilitate the work of spectroscopists. The faster the speed of rotation, the narrower the observed lines. We have proposed to acquire equipment that allows for the fastest sample spinning rates (up to 70'000 rotations / s, i.e., more than twice the speed currently available in our laboratory) in order to improve the chances of success of our projects in solid-state NMR analysing samples of amino acids, proteins, polymers, etc.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

Publications

Publication
Broadband excitation and indirect detection of nitrogen-14 in rotating solids using Delays Alternating with Nutation (DANTE)
Vitzthum V, Caporini MA, Ulzega S, Bodenhausen G (2011), Broadband excitation and indirect detection of nitrogen-14 in rotating solids using Delays Alternating with Nutation (DANTE), in JOURNAL OF MAGNETIC RESONANCE, 212(1), 234-239.
Efficiency at high spinning frequencies of heteronuclear decoupling methods designed to quench rotary resonance
Weingarth M, Trebosc J, Amoureux JP, Bodenhausen G, Tekely P (2011), Efficiency at high spinning frequencies of heteronuclear decoupling methods designed to quench rotary resonance, in SOLID STATE NUCLEAR MAGNETIC RESONANCE, 40(1), 21-26.
Sensitive C-13-C-13 correlation spectra of amyloid fibrils at very high spinning frequencies and magnetic fields
Weingarth M, Masuda Y, Takegoshi K, Bodenhausen G, Tekely P (2011), Sensitive C-13-C-13 correlation spectra of amyloid fibrils at very high spinning frequencies and magnetic fields, in JOURNAL OF BIOMOLECULAR NMR, 50(2), 129-136.

Knowledge transfer events

Active participation

Title Type of contribution Date Place Persons involved
EUROMAR 08.05.2011 Frankfurt


Communication with the public

Communication Title Media Place Year
Talks/events/exhibitions ENC International 01.03.2011

Awards

Title Year
aucune 2011

Associated projects

Number Title Start Funding scheme
124694 Methods for enhancing sensitivity and magnetisation lifetimes in liquid- and solid-state NMR 01.04.2009 Project funding (Div. I-III)
121303 Gyrotron for Dynamic Nuclear Polarisation Enhancement in Magic Angle Spinning Nuclear Magnetic Resonance Spectroscopy 01.03.2009 R'EQUIP
122708 Dynamic Nuclear Polarization Enhancement of Magic-Angle-Spinning Nuclear Magnetic Resonance Spectroscopy using gyrotrons 01.03.2009 Sinergia

Abstract

Magnetic interactions of nuclei with eachother and with the electric field due to electrons lead to broadening of the linewidths of NMR spectra of static powder samples. Most interactions can be averaged by a rapid rotation of the sample around an axis that is tilted through the 'magic angle', 54°, with respect to the static field. Very fast spinning, typically beyond 30 kHz, leads to very effective averaging and, therefore, to narrow and more intense lines. The technology of Magic-Angle Spinning (MAS) has evolved over the last decades, to the point where today the most reliable rotors can spin with speeds up to 70 kHz.We aim to acquire a fast-spinning detection probe in order to ensure that our research on improvement of heteronuclear decoupling methods, recoupling methods, and indirect detection of nitrogen-14 achieves its full potential.
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