Project

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A multimodal approach to cerebral blood flow and metabolism

English title A multimodal approach to cerebral blood flow and metabolism
Applicant Weber Bruno
Number 128625
Funding scheme SNSF Professorships
Research institution Klinik für Nuklearmedizin Departement Medizinische Radiologie Universitätsspital Zürich
Institution of higher education University of Zurich - ZH
Main discipline Neurophysiology and Brain Research
Start/End 01.04.2010 - 31.03.2012
Approved amount 680'630.00
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Keywords (10)

cerebral blood flow; cerebral meabolism; molecular imaging; optical imaging; functional neuroimaging; laser speckle imaging; cerebral metabolism; glucose; neuroscience; cortex

Lay Summary (English)

Lead
Lay summary
The brain's energy use is extremely high. Although only approximately 2% of the total body mass, it uses about a quarter of the total glucose. Glucose and oxygen are transported to the brain by a very complex cerebral vasculature. The processes governing the regulation of local cerebral blood flow are not well understood. Research in the field of neurovascular and neurometabolic coupling is highly relevant because it provides the basis for a better understanding of (1) microvascular components of cerebral pathologies, such as neurodegenerative diseases as well as of (2) functional imaging modalities based on cerebral blood flow as a surrogate of neuronal activity, such as functional magnetic resonance imaging. In the proposed project, we aim to continue our research on the cerebral microvascular anatomy and the spatiotemporal aspects of cerebral hemodynamics. In vivo and ex vivo experiments will be performed applying state-of-the-art imaging technologies that have been developed in the last three years. Using numerical simulations, we finally integrate anatomical and functional data to construct a comprehensive model of neurovascular and neurometabolic coupling mechanisms.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

Employees

Publications

Publication
Topology and hemodynamics of the cortical cerebrovascular system
Hirsch S., Reichold J., Schneider M., Szekely G., Weber B. (2012), Topology and hemodynamics of the cortical cerebrovascular system, in J Cereb Blood Flow Metab, 952-67.
Physiologically based construction of optimized 3-D arterial tree models
Schneider M., Hirsch S., Weber B., Szekely G. (2011), Physiologically based construction of optimized 3-D arterial tree models, in Medical image computing and computer-assisted intervention : MICCAI ... International Conference on , 14, 404-11.
Metabotropic glutamate receptor mGluR5 is not involved in the early hemodynamic response
Calcinaghi N., Jolivet R., Wyss M. T., Ametamey S. M., Gasparini F., Buck A., Weber B. (2011), Metabotropic glutamate receptor mGluR5 is not involved in the early hemodynamic response, in J Cereb Blood Flow Metab, 1-10.
Labeled acetate as a marker of astrocytic metabolism
Wyss M. T., Magistretti P. J., Buck A., Weber B. (2011), Labeled acetate as a marker of astrocytic metabolism, in J Cereb Blood Flow Metab, 1668-74.
In vivo evidence for lactate as a neuronal energy source
Wyss M. T., Jolivet R., Buck A., Magistretti P. J., Weber B. (2011), In vivo evidence for lactate as a neuronal energy source, in The Journal of Neuroscience, 31, 7477-85.
Vascularization of cytochrome oxidase-rich blobs in the primary visual cortex of squirrel and macaque monkeys
Keller A. L., Schuz A., Logothetis N. K., Weber B. (2011), Vascularization of cytochrome oxidase-rich blobs in the primary visual cortex of squirrel and macaque monkeys, in The Journal of Neuroscience, 31, 1246-53.
Assessment of brain responses to innocuous and noxious electrical forepaw stimulation in mice using BOLD fMRI
Bosshard S. C., Baltes C., Wyss M. T., Mueggler T., Weber B., Rudin M. (2010), Assessment of brain responses to innocuous and noxious electrical forepaw stimulation in mice using BOLD fMRI, in Pain, 151, 655-63.
Comment on recent modeling studies of astrocyte-neuron metabolic interactions
Jolivet R., Allaman I., Pellerin L., Magistretti P. J., Weber B. (2010), Comment on recent modeling studies of astrocyte-neuron metabolic interactions, in J Cereb Blood Flow Metab, 1982-6.
Noise in laser speckle correlation and imaging techniques
Skipetrov S. E., Peuser J., Cerbino R., Zakharov P., Weber B., Scheffold F. (2010), Noise in laser speckle correlation and imaging techniques, in Optics Express, 18, 14519-34.
Red blood cell distribution in simplified capillary networks
Obrist D., Weber B., Buck A., Jenny P. (2010), Red blood cell distribution in simplified capillary networks, in Philosophical transactions. Series A, Mathematical, physical, and engineering sciences, 368, 2897-918.
Model-based feature construction for multivariate decoding
Brodersen K. H., Haiss F., Ong C. S., Jung F., Tittgemeyer M., Buhmann J. M., Weber B., Stephan K. E. (2010), Model-based feature construction for multivariate decoding, in Neuroimage, 56, 601-15.
Functional and anatomical reorganization of the sensory-motor cortex after incomplete spinal cord injury in adult rats
Ghosh A., Sydekum E., Haiss F., Peduzzi S., Zorner B., Schneider R., Baltes C., Rudin M., Weber B., Schwab M. E. (2010), Functional and anatomical reorganization of the sensory-motor cortex after incomplete spinal cord injury in adult rats, in The Journal of Neuroscience, 29, 12210-9.
Rewiring of hindlimb corticospinal neurons after spinal cord injury
Ghosh A., Haiss F., Sydekum E., Schneider R., Gullo M., Wyss M. T., Mueggler T., Baltes C., Rudin M., Weber B., Schwab M. E. (2009), Rewiring of hindlimb corticospinal neurons after spinal cord injury, in Nature Neuroscience, 13, 97-104.
Deciphering neuron-glia compartmentalization in cortical energy metabolism
Jolivet R., Magistretti P. J., Weber B. (2009), Deciphering neuron-glia compartmentalization in cortical energy metabolism, in Frontiers in neuroenergetics, 1, 4-4.
A beta-scintillator for surface measurements of radiotracer kinetics in the intact rodent cortex
Wyss M. T., Obrist N. M., Haiss F., Eckert R., Stanley R., Burger C., Buck A., Weber B. (2009), A beta-scintillator for surface measurements of radiotracer kinetics in the intact rodent cortex, in Neuroimage, 48, 339-47.
Vascular graph model to simulate the cerebral blood flow in realistic vascular networks
Reichold J., Stampanoni M., Lena Keller A., Buck A., Jenny P., Weber B. (2009), Vascular graph model to simulate the cerebral blood flow in realistic vascular networks, in J Cereb Blood Flow Metab, 1429-43.
Improved in vivo two-photon imaging after blood replacement by perfluorocarbon
Haiss F., Jolivet R., Wyss M. T., Reichold J., Braham N. B., Scheffold F., Krafft M. P., Weber B. (2009), Improved in vivo two-photon imaging after blood replacement by perfluorocarbon, in The Journal of Physiology, 587, 3153-8.
Simultaneous 3D visualization and quantification of murine bone and bone vasculature using micro-computed tomography and vascular replica
Schneider P., Krucker T., Meyer E., Ulmann-Schuler A., Weber B., Stampanoni M., Muller R. (2009), Simultaneous 3D visualization and quantification of murine bone and bone vasculature using micro-computed tomography and vascular replica, in Microscopy research and technique, 72, 690-701.
Stimulation-induced increases of astrocytic oxidative metabolism in rats and humans investigated with 1-(11)C-acetate
Wyss M. T., Weber B., Treyer V., Heer S., Pellerin L., Magistretti P. J., Buck A. (2008), Stimulation-induced increases of astrocytic oxidative metabolism in rats and humans investigated with 1-(11)C-acetate, in J Cereb Blood Flow Metab, 29, 44-56.
The Microvascular System of the Striate and Extrastriate Visual Cortex of the Macaque
Weber B., Keller A. L., Reichold J., Logothetis N. K. (2008), The Microvascular System of the Striate and Extrastriate Visual Cortex of the Macaque, in Cereb Cortex, 2318-2330.
Spatiotemporal dynamics of cortical sensorimotor integration in behaving mice
Ferezou I., Haiss F., Gentet L. J., Aronoff R., Weber B., Petersen C. C. (2007), Spatiotemporal dynamics of cortical sensorimotor integration in behaving mice, in Neuron, 56, 907-23.
Quantification of cerebral blood flow in nonhuman primates using arterial spin labeling and a two-compartment model
Zappe A. C., Reichold J., Burger C., Weber B., Buck A., Pfeuffer J., Logothetis N. K. (2007), Quantification of cerebral blood flow in nonhuman primates using arterial spin labeling and a two-compartment model, in Magn Reson Imaging, 25, 775-83.
Uptake of 18F-Fluorocholine, 18F-FET, and 18F-FDG in C6 gliomas and correlation with 131I-SIP(L19), a marker of angiogenesis
Wyss M. T., Spaeth N., Biollaz G., Pahnke J., Alessi P., Trachsel E., Treyer V., Weber B., Neri D., Buck A. (2007), Uptake of 18F-Fluorocholine, 18F-FET, and 18F-FDG in C6 gliomas and correlation with 131I-SIP(L19), a marker of angiogenesis, in J Nucl Med, 608-14.
Quantitative evaluation of 11C-ABP688 as PET ligand for the measurement of the metabotropic glutamate receptor subtype 5 using autoradiographic studies and a beta-scintillator
Wyss M. T., Ametamey S. M., Treyer V., Bettio A., Blagoev M., Kessler L. J., Burger C., Weber B., Schmidt M., Gasparini F., Buck A. (2007), Quantitative evaluation of 11C-ABP688 as PET ligand for the measurement of the metabotropic glutamate receptor subtype 5 using autoradiographic studies and a beta-scintillator, in Neuroimage, 35, 1086-92.
Spatial specificity of BOLD versus cerebral blood volume fMRI for mapping cortical organization
Smirnakis S. M., Schmid M. C., Weber B., Tolias A. S., Augath M., Logothetis N. K. (2007), Spatial specificity of BOLD versus cerebral blood volume fMRI for mapping cortical organization, in J Cereb Blood Flow Metab, 27, 1248-61.
Quantitative modeling of laser speckle imaging
Zakharov P., Volker A., Buck A., Weber B., Scheffold F. (2006), Quantitative modeling of laser speckle imaging, in Opt Lett, 31, 3465-7.

Associated projects

Number Title Start Funding scheme
145007 Hyperpolarized Magnetic Resonance Metabolic Imaging - From Bench to Bedside 01.08.2013 R'EQUIP
110751 A multimodal approach to cerebral blood flow and metabolism 01.04.2006 SNSF Professorships

Abstract

The processes governing the regulation of local cerebral blood flow are not well understood. Research in the field of neurovascular and neurometabolic coupling is highly relevant because it provides the basis for a better understanding of (1) microvascular components of cerebral pathologies, such as neurodegenerative diseases as well as of (2) functional imaging modalities based on cerebral blood flow as a surrogate of neuronal activity, such as functional magnetic resonance imaging. In the proposed project, we aim to continue our research on the cerebral microvascular anatomy and the spatiotemporal aspects of cerebral hemodynamics. In vivo and ex vivo experiments will be performed applying state-of-the-art imaging technologies that have been developed in the last three years. Using numerical simulations, we finally integrate anatomical and functional data to construct a comprehensive model of neurovascular and neurometabolic coupling mechanisms.
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