embryonic stem cells; gene silencing; KRAB zinc finger proteins; KAP1; endogenous retroelements; imprinting; DNA methylation
Singh Kulwant, Cassano Marco, Planet Evarist, Sebastian Soji, Jang Suk Min, Sohi Gurjeev, Faralli Hervé, Choi Jinmi, Youn Hong-Duk, Dilworth F Jeffrey, Trono Didier (2015), A KAP1 phosphorylation switch controls MyoD function during skeletal muscle differentiation., in
Genes & development, 29(5), 513-25.
Rauwel Benjamin, Jang Suk Min, Cassano Marco, Kapopoulou Adamandia, Barde Isabelle, Trono Didier (2015), Release of human cytomegalovirus from latency by a KAP1/TRIM28 phosphorylation switch., in
eLife, 4, 0.
Fasching Liana, Kapopoulou Adamandia, Sachdeva Rohit, Petri Rebecca, Jönsson Marie E, Männe Christian, Turelli Priscilla, Jern Patric, Cammas Florence, Trono Didier, Jakobsson Johan (2015), TRIM28 represses transcription of endogenous retroviruses in neural progenitor cells., in
Cell reports, 10(1), 20-8.
Barde Isabelle, Rauwel Benjamin, Marin-Florez Ray Marcel, Corsinotti Andrea, Laurenti Elisa, Verp Sonia, Offner Sandra, Marquis Julien, Kapopoulou Adamandia, Vanicek Jiri, Trono Didier (2014), [A KRAB/KAP1-miRNA cascade regulates erythropoiesis through stage-specific control of mitophagy]., in
Médecine sciences : M/S, 30(1), 12-5.
Imbeault Michael, Trono Didier (2014), As time goes by: KRABs evolve to KAP endogenous retroelements., in
Developmental cell, 31(3), 257-8.
Castro-Diaz Nathaly, Ecco Gabriela, Coluccio Andrea, Kapopoulou Adamandia, Yazdanpanah Benyamin, Friedli Marc, Duc Julien, Jang Suk Min, Turelli Priscilla, Trono Didier (2014), Evolutionally dynamic L1 regulation in embryonic stem cells., in
Genes & development, 28(13), 1397-409.
Gubelmann Carine, Schwalie Petra C, Raghav Sunil K, Röder Eva, Delessa Tenagne, Kiehlmann Elke, Waszak Sebastian M, Corsinotti Andrea, Udin Gilles, Holcombe Wiebke, Rudofsky Gottfried, Trono Didier, Wolfrum Christian, Deplancke Bart (2014), Identification of the transcription factor ZEB1 as a central component of the adipogenic gene regulatory network., in
eLife, 3, 03346-03346.
Turelli Priscilla, Castro-Diaz Nathaly, Marzetta Flavia, Kapopoulou Adamandia, Raclot Charlène, Duc Julien, Tieng Vannary, Quenneville Simon, Trono Didier (2014), Interplay of TRIM28 and DNA methylation in controlling human endogenous retroelements., in
Genome research, 24(8), 1260-70.
Friedli Marc, Turelli Priscilla, Kapopoulou Adamandia, Rauwel Benjamin, Castro-Díaz Nathaly, Rowe Helen M, Ecco Gabriela, Unzu Carmen, Planet Evarist, Lombardo Angelo, Mangeat Bastien, Wildhaber Barbara E, Naldini Luigi, Trono Didier (2014), Loss of transcriptional control over endogenous retroelements during reprogramming to pluripotency., in
Genome research, 24(8), 1251-9.
Barde Isabelle, Rauwel Benjamin, Marin-Florez Ray Marcel, Corsinotti Andrea, Laurenti Elisa, Verp Sonia, Offner Sandra, Marquis Julien, Kapopoulou Adamandia, Vanicek Jiri, Trono Didier (2013), A KRAB/KAP1-miRNA cascade regulates erythropoiesis through stage-specific control of mitophagy., in
Science (New York, N.Y.), 340(6130), 350-3.
Andrey Guillaume, Montavon Thomas, Mascrez Bénédicte, Gonzalez Federico, Noordermeer Daan, Leleu Marion, Trono Didier, Spitz François, Duboule Denis (2013), A switch between topological domains underlies HoxD genes collinearity in mouse limbs., in
Science (New York, N.Y.), 340(6137), 1234167-1234167.
Rowe Helen M, Friedli Marc, Offner Sandra, Verp Sonia, Mesnard Daniel, Marquis Julien, Aktas Tugce, Trono Didier (2013), De novo DNA methylation of endogenous retroviruses is shaped by KRAB-ZFPs/KAP1 and ESET., in
Development (Cambridge, England), 140(3), 519-29.
Corsinotti Andrea, Kapopoulou Adamandia, Gubelmann Carine, Imbeault Michael, Santoni de Sio Francesca R, Rowe Helen M, Mouscaz Yoann, Deplancke Bart, Trono Didier (2013), Global and stage specific patterns of Krüppel-associated-box zinc finger protein gene expression in murine early embryonic cells., in
PloS one, 8(2), 56721-56721.
Márquez C, Poirier G L, Cordero M I, Larsen M H, Groner A, Marquis J, Magistretti P J, Trono D, Sandi C (2013), Peripuberty stress leads to abnormal aggression, altered amygdala and orbitofrontal reactivity and increased prefrontal MAOA gene expression., in
Translational psychiatry, 3, 216-216.
Rowe Helen M, Kapopoulou Adamandia, Corsinotti Andrea, Fasching Liana, Macfarlan Todd S, Tarabay Yara, Viville Stéphane, Jakobsson Johan, Pfaff Samuel L, Trono Didier (2013), TRIM28 repression of retrotransposon-based enhancers is necessary to preserve transcriptional dynamics in embryonic stem cells., in
Genome research, 23(3), 452-61.
Friedli Marc, Trono Didier, The developmental control of transposable elements and the evolution of higher species, in
Annual Revue Cell Develpment Biology.
KAP1 is a transcriptional silencer that serves as universal cofactor to the hundreds of KRAB-zinc finger proteins encoded by the genomes of higher vertebrates. We previously demonstrated that the KRAB/KAP1 system is essential to the homeostasis of embfyonic stem cells as it is responsible for the silencing of endogenous retroelements, the maintenance of impriting marks, and the establishment of site-specific DNA methylation patterns conserved during development. In the second phase of this grant, we will further explore the molecular mechanisms of these events, and the roles played by particular KRAB-ZFPs in this process.