Nanomedicine; Medicine; Cancer; Intelligent Materials; Nanoscience
Hunziker P (2015), Towards Personalized and Curative Medicine, in Bengt Fadeel (ed.), CRC press, London, 523-532.
Hunziker P (2013), Comprehensive targeting: the avenue to a personalized, highly effective, innocuous, and cost-effective medicine of the future., in European Journal of Nanomedicine
, 5, 3-4.
R Lehner X Wang S Marsch P Hunziker (2013), Intelligent nanomaterials for medicine: Carrier platforms and targeting strategies in the context of clinical application, in Nanomedicine: Nanotechnology, Biology and Medicine
, 9, 742-757.
R Lehner X Wang P Hunziker (2013), Plasmid linearization changes shape and efficiency of transfection complexes, in European Journal of Nanomedicine
, 5, 205-212.
Hunziker (2012), “Widespread orphan diseases”–A call for research, development strategies, and regulatory pathways for fre-quent diseases with multiple molecularly defined subgroups, in Eur J Nanomedicine
, 4, 55-56.
R Lehner X Wang M Wolf P Hunziker (2012), Designing switchable nanosystems for medical application, in J Controlled Release
, 161(2), 307-316.
Lehner R, Wang XY, Wolf M, Hunziker P (2012), Designing switchable nanosystems for medical application, in JOURNAL OF CONTROLLED RELEASE
, 161(2), 307-316.
Hunziker P (2012), Nanomedicine - shaping the medicine of the future
, 22(1), 22(1).
Hunziker Patrick (2012), Nanomedicine - shaping the medicine of the future, in ZEITSCHRIFT FUR MEDIZINISCHE PHYSIK
, 22(1), 1-3.
Wang Xueya, Wolf Marc P., Keel Rahel Banziger, Lehner Roman, Hunziker Patrick R. (2012), Polydimethylsiloxane embedded mouse aorta ex vivo perfusion model: proof-of-concept study focusing on atherosclerosis, in JOURNAL OF BIOMEDICAL OPTICS
, 17(7), 0760061-0760068.
R Lehner P Hunziker (2012), Why not just switch on the light?: light and its versatile applications in the field of nanomedicine, in European Journal of Nanomedicine
, 4, 73-80.
Morozov OV, Unser M, Hunziker P (2011), Reconstruction of Large, Irregularly Sampled Multidimensional Images. A Tensor-Based Approach, in IEEE TRANSACTIONS ON MEDICAL IMAGING
, 30(2), 366-374.
Egli S, Fischer B, Hartmann S, Hunziker P, Meier W, Rigler P (2010), Towards Targeted Drug Delivery by Covalent Ligand-Modified Polymeric Nanocontainers, in MODERN TRENDS IN POLYMER SCIENCE-EPF 09
, 296, 278-285.
The goals of the project are to develop, and to explore the medical utility of a novel class of intelligent synthetic nanoscale materials built from polymers, that are able to react upon external stimuli, to trigger or perform biochemical reactions, and to perform this functionality on the level of a target cell and within the organism and to assess the potential of such materials in cancer in cell culture and small animal models.By combining medical synthesis, physical characterisation, and biomedical evaluation, we have created a number of novel intelligent materials that proved to be highly promizing for future cancer therapies: They are non-toxic, are able to target cancer tissues in several human cancer models selectively, and can be "switched on" at the target to exert strong therapeutic effects while sparing healthy cells and tissues.