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Conditional triggered drug release

English title Conditional triggered drug release
Applicant Fromm Katharina M.
Number 126055
Funding scheme NRP 62 Smart Materials
Research institution Département de Chimie Université de Fribourg
Institution of higher education University of Fribourg - FR
Main discipline Inorganic Chemistry
Start/End 01.07.2010 - 28.02.2015
Approved amount 642'867.00
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All Disciplines (5)

Discipline
Inorganic Chemistry
Organic Chemistry
Diseases of Bones and Joints
Experimental Microbiology
Medical Microbiology

Keywords (6)

Antimicrobial compounds; Nano-containers; Triggered drug release; Molecular Recognition; DNA-templated synthesis; Signal transduction

Lay Summary (English)

Lead
Lay summary
Conditional triggered drug release from nanocontainers

Nanocontainers loaded with antibacterial compounds are to be coupled on implant surfaces with biosensors in such a way that the nanocontainers can release antibiotics only in the presence of bacteria.

Background
Today’s medicinal technology offers a wide and still increasing variety of implants that are required by a growing number of patients. As more and more implants are
used in various branches of medicine, also the number of postoperative infections increases with corresponding financial consequences. In addition, there exists a growing resistance of bacteria towards antibiotics.

Aim
The main target is the development of novel implant coatings with antibacterial function. One part of the research consists of the synthesis of suitable nanocontainers loaded with antibiotics. A second part is devoted to the development of bacteria sensors. As a straightforward approach the drug containing nanocapsules are coupled with biosensors. The novel coatings will release the antibacterial drug only upon bacterial presence.

Significance
The novel coatings of implants to be developed will not only significantly reduce the risk of postoperative infections but will also prevent bacterial resistance toward antibiotics. Both aspects are relevant with regard to health costs.

Application
A first direct application of the drug loaded nanocontainers coupled with bacteria sensors is the coating of medical implants for various surgical techniques. Apart from surgical implants, the novel materials could be used in other sectors such as food technology, hygiene or human care.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

Employees

Publications

Publication
Toxicity and Protective Effects of Cerium Oxide Nanoparticles (Nanoceria) Depending on Their Preparation Method, Particle Size, Cell Type, and Exposure Route
Gagnon Jacinthe, Fromm Katharina M. (2015), Toxicity and Protective Effects of Cerium Oxide Nanoparticles (Nanoceria) Depending on Their Preparation Method, Particle Size, Cell Type, and Exposure Route, in Eur. J. Inorg. Chem., 27, 4510.
Nanobio Silver – Its Interactions with Peptides & Bacteria, and Its Uses in Medicine
Eckhardt Sonja, Brunetto P. S., Gagnon Jacinthe, Priebe Magdalena, Giese Bernd, Fromm Katharina M. (2013), Nanobio Silver – Its Interactions with Peptides & Bacteria, and Its Uses in Medicine, in Chem. Rev., 113, 4708-4754.
Nanoencapsulation of Anti-Microbial Drugs
Gagnon Jacinthe, Weber Pierric, Fromm Katharina M. (2011), Nanoencapsulation of Anti-Microbial Drugs, in Europ. Cells & Materials, ecm journal, ecm journal.
One-pot synthesis and catalytic properties of encapsulated silver nanoparticles in silica nanocontainers
Priebe Magdalena, Fromm Katharina M. (2011), One-pot synthesis and catalytic properties of encapsulated silver nanoparticles in silica nanocontainers, in Europ. Cells & Materials, Wiley, Wiley.
Integrating Silver Compounds and Nanoparticles into Ceria Nanocontainers for Antimicrobial Applications
Gagnon Jacinthe, Clift Martin J. D., Vanhecke D., Kuhn D. A., Weber P., Petri-Fink Alke, Rothen-Rutishauser B., Fromm Katharina M., Integrating Silver Compounds and Nanoparticles into Ceria Nanocontainers for Antimicrobial Applications, in Journal of Materials Chemistry B.
Nanorattles or Yolk-Shell Nanoparticles - What they are, How are they Made, and What Are They Good For?
Priebe Magdalena, Fromm Katharina M., Nanorattles or Yolk-Shell Nanoparticles - What they are, How are they Made, and What Are They Good For?, in Chem. Eur. J., 20.

Collaboration

Group / person Country
Types of collaboration
Dr. Nina Khanna, Uni Spital Basel, CH Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
Prof. Bernard Grobéty, Fribourg Center of Nanomaterials FriMat Switzerland (Europe)
- Research Infrastructure
Prof. C. Bourquin, Departement Medizin, Uni Fribourg Switzerland (Europe)
- Research Infrastructure

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
Forum OFAC Talk given at a conference Smart Materials for Medicine 26.09.2014 Basel, Switzerland Fromm Katharina M.;
CLINAM Talk given at a conference Nanoencapsulation of Silver-based antimicrobial drugs 23.06.2014 Basel, Switzerland Gagnon Jacinthe;
Jahresversammlung der Schweizerischen Gesellschaft für Mikrobiologie Talk given at a conference Combating Implant Infection with Smart Nanotechnology 20.06.2014 Fribourg, Switzerland Fromm Katharina M.;
Snow Symposium of the Swiss Chemical Society Talk given at a conference Towards a DNA-based bacterial sensor 24.01.2014 Saas Fee, Switzerland Janett Elia;
International Congress of Young Chemists "YoungChem2013" Talk given at a conference Microemulsion approach to Ag@SiO2 nanorattles 09.10.2013 Poznan, Poland Fromm Katharina M.;
Fall Meeting of the Swiss Chemical Society Talk given at a conference Towards a DNA-Based Bacterial Sensor 06.09.2013 Lausanne, Switzerland Janett Elia; Bochet Christian;
Fall Meeting of the Swiss Chemical Society Poster Conditional Triggered Drug Release 06.09.2013 Lausanne, Switzerland Bochet Christian; Janett Elia; Cotting Tatiana;
Fall Meeting of the Swiss Chemical Society Poster One-pot synthesis of antimicrobial Ag@SiO2 nano-rattle through the microemulsion approach 06.09.2013 Lausanne, Switzerland Fromm Katharina M.; Bochet Christian; Cotting Tatiana; Janett Elia;
Fall Meeting of the Swiss Chemical Society Talk given at a conference Towards a DNA-based bacterial sensor 06.09.2013 Lausanne, Switzerland Janett Elia;
FriMat Day 2013 Poster One-pot synthesis of catalytic Ag@SiO2 nano-rattles 04.07.2013 Fribourg, Switzerland Bochet Christian; Fromm Katharina M.;
CLINAM, The European Foundation for Clinical Nanomedicine Poster NRP-62: Conditional Triggered Drug Release 25.06.2013 Basel, Switzerland Gagnon Jacinthe; Cotting Tatiana; Fromm Katharina M.; Janett Elia; Bochet Christian;
Technology Briefing NRP 62 Poster NRP-62: Conditional Triggered Drug Release 17.06.2013 Dübendorf, Switzerland Gagnon Jacinthe; Fromm Katharina M.; Janett Elia; Bochet Christian; Cotting Tatiana;
Particulate Fluids Processing Center (PFPC) Meeting Talk given at a conference Nanoencapsulation of Antimicrobial Drugs 11.06.2013 Melbourne, Australia Gagnon Jacinthe;
Kick of Meeting of NRP-62 2nd phase Talk given at a conference NRP-62: Conditional Triggered Drug Release 30.05.2013 Murten, Switzerland Bochet Christian; Janett Elia; Fromm Katharina M.; Cotting Tatiana; Gagnon Jacinthe;
2nd research day in medicine of the university of Fribourg Poster Inorganic nanocontainers modulate immune responses 22.05.2013 Fribourg, Switzerland Fromm Katharina M.;
Workshop on Sensing Applications of Supramolecular Chemistry Poster Nanoencapsulation of Antimicrobial Drugs 25.03.2013 Plovdiv, Bulgaria Fromm Katharina M.; Gagnon Jacinthe;
Workshop "Sensing Applications of Supramolecular Chemistry" Poster Conditional Triggered Drug Release 25.03.2013 Plovdiv, Bulgaria Bochet Christian; Janett Elia; Cotting Tatiana;
Rigi-Workshop 2013: Thinking Big in a Small World: Creativity in the Molecular Sciences Poster One-pot synthesis and encapsulation of silver nanoparticles into silica nanocontainers 22.01.2013 Rigi Kulm, Switzerland Fromm Katharina M.;
Fall Meeting of the Swiss Chemical Society Poster Nanoencapsulation of Antimicrobial Drugs 13.09.2012 Zurich, Switzerland Janett Elia; Gagnon Jacinthe; Bochet Christian; Fromm Katharina M.; Cotting Tatiana;
1st-year graduate student symposium Talk given at a conference Nanoencapsulation of Silver-Based Drugs 11.09.2012 Bern, Switzerland Gagnon Jacinthe; Fromm Katharina M.; Janett Elia;
CUSO Summer School Poster Conditional Triggered Drug Release 26.08.2012 Villars-sur-Ollon, Switzerland Bochet Christian; Janett Elia; Cotting Tatiana;
3rd International Conference on Nanotechnology: Fundamentals and Applications, Montreal, Canada Talk given at a conference Nanoencapsulation of Silver-Based Drugs 07.08.2012 Montreal, Canada Fromm Katharina M.; Gagnon Jacinthe;
1st year Graduate Student Symposium Talk given at a conference Conditional Triggered Drug Release (2 talks) 10.09.2011 Bern, Switzerland Cotting Tatiana; Janett Elia;
CUSO Summer Schools 2010/2011 Poster 3 Posters on "Conditional Triggered Drug Release" 15.08.2010 Villars-sur-Ollon, Switzerland Bochet Christian; Cotting Tatiana; Janett Elia;


Self-organised

Title Date Place
Treffen aller NFP62-Gruppen, die mit Nanokapseln arbeiten 22.08.2011 Fribourg, Switzerland

Knowledge transfer events

Active participation

Title Type of contribution Date Place Persons involved
Technology Briefing NRP 62 Poster 17.06.2013 Dübendorf, Switzerland Fromm Katharina M.; Cotting Tatiana; Janett Elia; Gagnon Jacinthe; Bochet Christian;
Technology Apero Talk 14.09.2011 Fribourg, Switzerland Gagnon Jacinthe; Janett Elia; Fromm Katharina M.; Cotting Tatiana; Bochet Christian;
Technology Apero Talk 16.05.2011 Basel, Switzerland Fromm Katharina M.;


Self-organised

Title Date Place
Nanocontainer Workshop 22.08.2011 Fribourg, Switzerland

Communication with the public

Communication Title Media Place Year
Media relations: print media, online media Materials - Science and Technology in Fribourg: A nanomaterials & mega-networking hub FRM-Magazine German-speaking Switzerland Western Switzerland Italian-speaking Switzerland International Rhaeto-Romanic Switzerland 2013
Media relations: print media, online media A silver solution International Innovation International 2012

Awards

Title Year
Prix Jaubert 2018
ACS Fellow (K. M. Fromm is the first scientist in Europe and only the third non-US citizen to receive this nomination from the American Chemical Society) 2013
Best Poster Award (1st Prize) at the Workshop "Sensing Applications of Supramolecular Chemistry" in Plovdiv, Bulgaria 2013
Best oral presentation at the Snow Symposium 2012

Patents

Title Date Number Inventor Owner
Sensor 21.10.2010 PCT/EP2011/068563

Associated projects

Number Title Start Funding scheme
139226 IncuCyte-based high throughput imaging-based platform for determination of cellular and molecular events in real time in cultured cells in vitro: application to nanomaterial studies, cancer and cardiovascular research 01.12.2011 R'EQUIP
139147 R'Equip grant proposal for a MALDI ToF mass spectrometer 01.04.2012 R'EQUIP

Abstract

The number of patients requiring joint replacement or internal fixation devices is steadily increasing. E.g. in the U.S., 600’000 joint prostheses and 2 million fracture fixation devices are implanted every year. Infections of these implants can become a very serious problem, the infection rate being ca. 1-2% for hip or knee implants, and up to almost 20% for pacemakers. These infections frequently occur perioperatively by bacterial contamination of the surgical site, which form biofilms, allowing bacteria to resist antimicrobial agents and immune responses. We therefore propose to develop new materials which i) release drugs only when and where they are needed, ii) dramatically reduce the percentage of implant infection, iii) decrease the trend of resistance build-up by bacteria, iv) reduce health costs, v) improve the quality of life for patients, and vi) yield new products to be produced and sold by manufacturers of implants and fracture fixation devices. In two work packages, we will i) develop a concept of drug-filled nanocontainers attached to a (coated) implant surface and ii) bacterial sensors which shall trigger increased drug release from these nanocapsules.
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