Swiss National Cohort; Cardiovascular disease; Mortality; Social inequality; Risk factors; French paradox; CVD risk score; Calibration; CHD; stroke; self-perceived health; self-reported data; surveys; large nested project; Swiss National Cohort 2.0
Faeh David (2016), Independent at heart: persistent association of altitude with ischemic heart disease mortality after consideration of climate, topography and built environment - a longitudinal cohort study, in JECH
, 70, 798-806.
Wanner Miriam, Tarnutzer Silvan, Martin Brian W, Braun Julia, Rohrmann Sabine, Bopp Matthias, Faeh David (2014), Impact of different domains of physical activity on cause-specific mortality: A longitudinal study, in Preventive Medicine
, 62, 89-95.
Roh Lucienne, Braun Julia, Chiolero Arnaud, Bopp Matthias, Rohrmann Sabine, Faeh David (2014), Mortality risk associated with underweight: a census-linked cohort of 31,578 individuals with up to 32 years of follow-up, in BMC Public Health
, 14, 371.
Bopp Matthias, Braun Julia, Faeh David (2014), Variation in mortality patterns among the general population, study participants and different types of nonparticipants: evidence from 25 years of follow-up, in AJE
, 180(10), 1028-1035.
Braun Julia, Bopp Matthias, Faeh David (2013), Blood glucose may be an alternative to cholesterol in CVD risk prediction models, in Cardiovascular Diabetology
, 12, 24.
Faeh David, Braun Julia, Rufibach Kaspar, Puhan Milo A, Marques-Vidal Pedro, Bopp Matthias (2013), Country specific and up to date cardiovascular risk charts can be efficiently obtained with record linkage of routine and observational data, in PLoS ONE
, 8(2), e56149.
Maag Judith, Braun Julia, Bopp Matthias, Faeh David (2013), Direct estimation of death attributable to smoking in Switzerland based on record linkage of routine and observational data, in Nicotine&Tobacco Research
, 15, 1588-1597.
Rohrmann Sabine, Braun Julia, Bopp Matthias, Faeh David (2013), Inverse association between circulating vitamin D and mortality – dependent on sex and cause of death?, in Nutrition, Metabolism and Cardiovascular Diseases
, 23, 960-966.
von Gunten Elisabeth, Braun Julia, Bopp Matthias, Keller Ulrich, Faeh David (2013), J-shaped association between plasma glucose concentration and cardiovascular disease mortality over a follow-up of 32 years, in Preventive Medicine
, 57, 623-628.
Van Hemelrijck Mieke, Eichholzer Monika, Faeh David, Rohrmann Sabine (2012), Ability of a biomarker-based score to predict death from circulatory disease and cancer in NHANES III., in BMC public health
, 12(1), 895-895.
Faeh David, Braun Julia, Bopp Matthias (2012), Body mass index vs cholesterol in cardiovascular disease risk prediction models, in Archives of Internal Medicine
, 172, 1766-1768.
Bopp Matthias, Braun Julia, Gutzwiller Felix, Faeh David (2012), Health Risk or Resource? Gradual and Independent Association Between Self-Rated Health and Mortality Persists Over 30 Years, in PloSOne
, 7(2), 0-0.
Faeh David, Hauser Renward (2012), Possible consequences of the new operation criteria for bariatric surgery in Switzerland., in Obesity surgery
, 22(1), 192-3.
Bopp Matthias, Faeh David (2012), Response to comment on: Routine Data Sources Challenge International Diabetes Federation Extrapolations of National Diabetes Prevalence in Switzerland. Diabetes Care. 2011;34:2387-2389, in Diabetes Care
Faeh David, Braun Julia, Tarnutzer Silvan, Bopp Matthias (2011), Obesity but not overweight is associated with increased mortality risk., in European journal of epidemiology
, 26(8), 647-55.
Faeh D, Braun J, Bopp M (2011), Prevalence of obesity in Switzerland 1992-2007: the impact of education, income and occupational class., in Obesity reviews : an official journal of the International Association for the Study of Obesity
, 12(3), 151-66.
Faeh David, Braun Julia, Tarnutzer Silvan, Bopp Matthias (2011), Public health significance of four cardiovascular risk factors assessed 25 years ago in a low prevalence country., in European journal of cardiovascular prevention and rehabilitation : official journal of the European
Bopp Matthias, Zellweger Ueli, Faeh David (2011), Routine data sources challenge international diabetes Federation extrapolations of national diabetes prevalence in Switzerland., in Diabetes care
, 34(11), 2387-9.
Faeh David, Gutzwiller Felix, Bopp Matthias (2010), Correspondence: Response to Letters Regarding Article, "Lower Mortality from Coronary Heart Disease and Stroke at Higher Altitudes in Switzerland" Circulation. 2010;121:e378, in Circulation
, 121, e378-e379.
Faeh David, Bopp Matthias, Swiss National Cohort Study Group (2010), Educational inequalities in mortality and associated risk factors: German--versus French-speaking Switzerland., in BMC public health
, 10, 567-567.
Bopp Matthias, Braun Julia, Faeh David, Gutzwiller Felix, Swiss National Cohort Study Group (2010), Establishing a follow-up of the Swiss MONICA participants (1984-1993): record linkage with census and mortality data., in BMC public health
, 10, 562-562.
Faeh D, Bopp M (2010), Excess weight in the canton of Zurich, 1992-2009: harbinger of a trend reversal in Switzerland?, in Swiss medical weekly
, 140, 13090-13090.
Faeh David, Bopp Matthias (2010), Increase in the prevalence of obesity in Switzerland 1982-2007: birth cohort analysis puts recent slowdown into perspective., in Obesity (Silver Spring, Md.)
, 18(3), 644-6.
Bopp Matthias, Faeh David (2010), Where have all the conscripts gone?, in Swiss medical weekly
, 140(23-24), 354-354.
Faeh D, Braun J, Bopp M (2009), Underestimation of obesity prevalence in Switzerland: comparison of two methods for correction of self-report., in Swiss medical weekly
, 139(51-52), 752-6.
Background.Besides obesity and diabetes, risk factors for cardiovascular disease (CVD) include hypertension, unfavourable lipid profile and smoking. Based on these classical risk factors, algorithms have been proposed to assess an individual’s risk for fatal and non-fatal CVD events. In the past decades, several additional biological, socio-economic, psycho-social and lifestyle CVD risk factors emerged. Such data is typically gathered with cross-sectional, representative health surveys but only rarely combined with a mortality follow-up. Also, measuring risk factors in a general population is expensive: data are thus scarce and geographically limited. Only few studies have evaluated the potential of survey data in predicting CVD mortality and disentangling the respective contributions of risk factors. This project aims at compensating the lack of population-based cohorts relating risk factors with CVD mortality in Switzerland. Switzerland deserves special attention, as the incidence of CVD is globally low, albeit with a distinct gradient by socio-economic status (SES). Also, and similarly to that found between northern and southern regions of Europe, there is a pronounced German-Latin gradient for CVD risk factors and CVD mortality. Specific aims. With this project the following specific research questions will be answered:•What is the contribution of classical and additional lifestyle, SES, psycho-social and biological risk factors to the prediction of CVD mortality? Is alcohol consumption an effect modifier?•How much of the geographical patterns (e.g. difference between French, Italian and German Switzerland) and the SES gradient in CVD mortality are explained by lifestyle factors such as smoking, alcohol consumption and obesity? •How valid are the widely used CVD risk scores in the Swiss context? •Can CVD mortality be predicted by self-reported risk factors and derived multivariate risk models and how does this prediction perform compared to that of classical risk algorithms? Methods. To obtain a longitudinal design, we will construct historical cohorts based on four population-based surveys linked with the Swiss National Cohort (SNC), i.e., a nationwide record linkage of census data and death certificates since 1990. Linkage for deaths between 1977 and 1990 will be done with this project. All surveys have been carried out between 1977 and 1993. They include nearly 40,000 participants and provide comparable information on risk factors. Summing up the follow-up time of all study participants, we will obtain 630,000 person-years and we expect to obtain 7,400 deaths, of which 3,300 due to CVD. The SNC will provide additional socio-demographic information (e.g. place of birth, household type, main language, dwelling attributes and changes in these variables) as well as survival time and cause of death. Poisson, logistic and proportional hazards (Cox and Weibull) regression will be used to examine the independent effects of risk factors on mortality. For discrimination and calibration of risk scores we will apply C statistics and modified Hosmer-Lemeshow statistics and alternative measures of fit. Significance. The quality and the wide range of information, a follow-up time of 30 years and the number of subjects in this study will enable to assess the respective contributions of CVD risk factors in the different language regions of Switzerland. The cultural diversity of this country will further allow a simulation of European patterns within common health care and data management systems. Special attention will be devoted to the role of alcohol consumption, as a low-moderate consumption can be protective and a higher consumption harmful. This project will also permit to evaluate, how indicators of self-reported health and well-being can increase the efficacy in predicting CVD mortality. Since measured data on population level is lacking, multivariate risk models derived from health surveys could allow monitoring of distinct subpopulations and trends. Modelled absolute risk estimations can be adopted to validate and recalibrate CVD risk algorithms in order to provide clinicians a customized tool that improves risk assessment in their patients and facilitates decision making. In light of the large SES gradient found in Switzerland, efforts should be taken in order to reduce the disparity in CVD mortality. We aim at providing information on CVD risk factors that mediate the difference in mortality between high and low SES strata. These findings could indicate public health authorities fields for intervention and make an important contribution to the international discussion. The presented project offers the unique opportunity to establish a life course approach in a cost-efficient and elegant manner. It further exploits the potential of the SNC which is one of the largest longitudinal datasets worldwide. The combination with risk factor data from population surveys generates substantial added value and is much more than just an additional feature. It will provide for all parts of Switzerland region-specific results in many aspects comparable with those from a large - very costly, time consuming and still less representative - cohort study.