Project

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The conversion of mild cognitive impairement to alzheimer's disease

English title The conversion of mild cognitive impairement to alzheimer's disease
Applicant Hock Christoph
Number 124111
Funding scheme SPUM
Research institution Abteilung für Psychiatrische Forschung Psychiatrische Universitätsklinik Zürich
Institution of higher education University of Zurich - ZH
Main discipline Neurology, Psychiatry
Start/End 01.07.2009 - 30.06.2016
Approved amount 3'555'174.00
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Keywords (2)

MCI; Alzheimers Disease

Lay Summary (English)

Lead
Lay summary
This project is designed to reveal the fundamental biological factors that determine the conversion from benign memory impairment in the elderly, also referred to as "mild cognitive impairment", to overt dementia, in particular Alzheimer's disease. Alzheimer's disease affects approximately 100'000 individuals in Switzerland, 5 million in the United States and 15 million worldwide. Alzheimer's disease is a chronic, progressive, neurodegenerative disorder that places a substantial burden on patients, their families, the communities and health care systems. Approximately 15% of subjects with mild cognitive impairment convert to Alzheimer's disease every year, indicating that mild cognitive impairment is a precursor syndrome of Alzheimer's disease. Halting cognitive decline at the mild cognitive impairment stage would essentially result in the prevention of Alzheimer's disease. This longitudinal naturalistic study aims at following the course of 300 elderly subjects with mild cognitive impairment over time. The clinical investigations comprise neuropsychology, neuroimaging procedures (MRI, PET), genetics and immunological tests in blood. This study is a joint endeavor of the Universities of Zurich, Geneva and Basel with an integrated training program for young physician scientists.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

Employees

Name Institute
Bouchet Noemie
Graf Christophe Abteilung für Psychiatrische Forschung Psychiatrische Universitätsklinik Zürich
Summermatter Daniel
Fisch Karin Abteilung für Psychiatrische Forschung Psychiatrische Universitätsklinik Zürich
Xekardaki Aikaterini Dépt. de Médecine Communautaire Policlinique de Médecine HUG
Meynet Marie-Pierre
Lorin Belhoucine Danièle
Kulic Luka Institut für Regenerative Medizin Medizinische Fakultät Universität Zürich
Riese Florian Psychiatric University Hospital Zurich Division of Psychiatry Research and Division of Psychogeriatric Medicine
Saake Antje
Bächinger Marc Neuronale Bewegungskontrolle Dept. Gesundheitswiss. und Technologie ETH Zürich
Carlier Sabrina Abteilung für Psychiatrische Forschung Psychiatrische Universitätsklinik Zürich
Prelaz Catherine Abteilung für Psychiatrische Forschung Psychiatrische Universitätsklinik Zürich
Florian Riese
Meyer Rafael Serafin
Rodriguez Cristelle
Leuzinger Andrea
Montandon Varoda Zaidi Maria Luiza Service de Médecine Nucléaire Hôpitaux Universitaires de Genève
Heyrani Nobari Bentolhoda
Missonnier-Evrard Pascal
Missonnier Pascal Applied neurophysiology Research Laboratory Dept. of Neuroscience and Movment Sciencce Section Medicine
Laurencet Patricia Alexandra
Giannelli Sandra Véronique Abteilung für Psychiatrische Forschung Psychiatrische Universitätsklinik Zürich
Schreiner Bettina Department of Neuroradiology University Hospital of Zurich
Martin-Casas Raphaelle
Moullet Barbara
Mikos Ania UFSP Dynamik Gesunden Alterns Universität Zürich

Associated projects

Number Title Start Funding scheme
125378 Imaging Brain Beta-Amyloid in Asymptomatic Elderly Subjects 01.08.2009 Project funding

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