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The conversion of mild cognitive impairement to alzheimer's disease

English title The conversion of mild cognitive impairement to alzheimer's disease
Applicant Hock Christoph
Number 124111
Funding scheme SPUM
Research institution Abteilung für Psychiatrische Forschung Psychiatrische Universitätsklinik Zürich
Institution of higher education University of Zurich - ZH
Main discipline Neurology, Psychiatry
Start/End 01.07.2009 - 30.06.2016
Approved amount 3'555'174.00
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Keywords (2)

MCI; Alzheimers Disease

Lay Summary (English)

Lay summary
This project is designed to reveal the fundamental biological factors that determine the conversion from benign memory impairment in the elderly, also referred to as "mild cognitive impairment", to overt dementia, in particular Alzheimer's disease. Alzheimer's disease affects approximately 100'000 individuals in Switzerland, 5 million in the United States and 15 million worldwide. Alzheimer's disease is a chronic, progressive, neurodegenerative disorder that places a substantial burden on patients, their families, the communities and health care systems. Approximately 15% of subjects with mild cognitive impairment convert to Alzheimer's disease every year, indicating that mild cognitive impairment is a precursor syndrome of Alzheimer's disease. Halting cognitive decline at the mild cognitive impairment stage would essentially result in the prevention of Alzheimer's disease. This longitudinal naturalistic study aims at following the course of 300 elderly subjects with mild cognitive impairment over time. The clinical investigations comprise neuropsychology, neuroimaging procedures (MRI, PET), genetics and immunological tests in blood. This study is a joint endeavor of the Universities of Zurich, Geneva and Basel with an integrated training program for young physician scientists.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants


Name Institute

Associated projects

Number Title Start Funding scheme
125378 Imaging Brain Beta-Amyloid in Asymptomatic Elderly Subjects 01.08.2009 Project funding