neuroscience; decision making; social decision making; self-control; neuroimaging; brain stimulation; impulse control disorder; dopamine; genetics
Knoch Daria, Schiller Bastian (2012), Neuronales Bremspedal, in Gehirn und Geist
, Januar/Februar, 44-55.
Gianotti Lorena, Figner Bernd, Ebstein Robert, Knoch Daria (2012), Why some people discount more than others: baseline activation in the dorsal PFC mediates the link between COMT genotype and impatient choice, in Frontiers in Decision Neuroscience
Baumgartner Thomas, Knoch Daria, Hotz Philine, Eisenegger Christoph, Fehr Ernst (2011), Dorsolateral and ventromedial prefrontal cortex orchestrate normative choice., in Nature Neuroscience
, 14(11), 1468-74.
Figner Bernd, Knoch Daria, Johnson Eric, Krosch Amy, Lisanby Sarah, Fehr Ernst, Weber Elke (2010), Lateral prefrontal cortex and self-control in intertemporal choice, in NATURE NEUROSCIENCE
, 13(5), 538-539.
Eisenegger Christoph, Knoch Daria, Ebstein Richard, Gianotti Lorena, Sandor Peter, Fehr Ernst (2010), Dopamine Receptor D4 Polymorphism Predicts the Effect of L-DOPA on Gambling Behavior, in BIOLOGICAL PSYCHIATRY
, 67(8), 702-706.
Knoch Daria, Gianotti Lorena, Baumgartner Thomas, Fehr Ernst (2010), A Neural Marker of Costly Punishment Behavior, in PSYCHOLOGICAL SCIENCE
, 21(3), 337-342.
Knoch Daria, Schneider Frederic, Schunk Daniel, Hohmann Martin, Fehr Ernst (2009), Disrupting the prefrontal cortex diminishes the human ability to build a good reputation, in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
, 106(49), 20895-20899.
Eisenegger Christoph, Pedroni Andreas, Rieskamp Jörg, Zehnder Christian, Ebstein Robert, Fehr Ernst, Knoch Daria, DAT1 Polymorphism Determines L-DOPA Effects on Learning about Others’ Prosociality, in Plos One
Baumgartner Thomas, Schiller Bastian, Rieskamp Jörg, Gianotti Lorena, Knoch Daria, Diminishing parochialism in intergroup conflict by disrupting the right temporo-parietal junction, in Social and Affective Neuroscience
Pedroni Andreas, Eisenegger Christoph, Hartmann Matthias, Fischbacher Urs, Knoch Daria, Dopaminergic Stimulation Increases Selfish Behavior in the Absence of Punishment Threat, in Psychopharmacology
Schiller Bastian, Gianotti Lorena, Nash Kyle, Knoch Daria, EEG baseline activation in lateral prefrontal regions is related to individual differences in an electrophysiological marker of response inhibition capacity, in Cerebral Cortex
Baumgartner Thomas, Schiller Bastian, Hill Christopher, Knoch Daria, Impartiality in humans is predicted by brain structure of dorsomedial prefrontal cortex, in NeuroImage
Baumgartner Thomas, Gianotti Lorena, Knoch Daria, Who is honest and why: Baseline activation in anterior insula predicts inter-individual differences in deceptive behavior, in Biological Psychology
The capacity of self-control, i.e. the conscious control of thought, action, and emotions, is essential for adaptive decision making. Problems revolving around self-control failure are numerous (e.g. spending sprees, eating binges, pathological gambling, substance addiction, risk seeking behavior). Moreover, self-control failure is a key component in a variety of neurological and psychiatric syndromes. In addition to their importance in individual decision making, self-control processes are of fundamental significance in social interaction behavior. For example, appropriate social conduct often requires individuals to control or regulate their internal demands or desires in order to conform to social rules and moral norms. The study of self-control can be significantly improved, taking relatively newly emerging theoretical and empirical perspectives as well as new methodological directions into account. The proposed research program has a strong interdisciplinary focus involving psychology, economics, and neuroscience. It aims to answer the following questions: Which brain regions are involved in the neural networks that implement self-control processes? Can pharmacological interventions or external brain stimulation modulate these processes? Do any individual dispositions explain why some individuals have higher self-control capacities than others?From a theoretical and empirical perspective, I will use paradigms derived from social psychology and economics that allow examining self-control processes in highly complex social and non-social situations. From a methodological perspective, these paradigms will be investigated using neuroscientific research methods such as brain stimulation techniques, pharmacological intervention, metabolic and electrical functional imaging, and molecular genetics. The specific scientific aims are i) to characterize the neural mechanisms underlying self-control by experimentally manipulating brain activity with transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS), ii) using pharmacological interventions to investigate the neurochemical nature of mechanisms underlying self-control, and iii) to investigate whether individual dispositional differences in neural and genetic characteristics might explain individual variability in self-control ability. A better understanding of the neural mechanisms that underlie self-control processes has implications for our understanding of the processes leading to substance addiction and other impulse control disorders, as well as to social conduct disorders. Furthermore, it may open up avenues for the development of novel, focal, and effective therapeutic strategies.The ambitious project plan profits from collaborations with outstanding national and international institutes and will contribute to a further understanding of the neural basis of self-control and social functioning.