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Cardiovascular diseases and psychiatric disorders in the general population: a prospective follow-up study

English title Cardiovascular diseases and psychiatric disorders in the general population: a prospective follow-up study
Applicant Preisig Martin
Number 122661
Funding scheme Cohort Studies Large
Research institution Dépt. Universitaire de Psychiatrie Adulte Département de Psychiatrie CHUV
Institution of higher education University of Lausanne - LA
Main discipline Internal Medicine
Start/End 01.01.2009 - 31.03.2012
Approved amount 4'920'000.00
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All Disciplines (4)

Discipline
Internal Medicine
Methods of Epidemiology and Preventive Medicine
Genetics
Neurology, Psychiatry

Keywords (7)

Mental diseases; Cardiovascular risk factors; Cardiovascular diseases; Epidemiology; Genetics; Public Health; Mental disorders

Lay Summary (English)

Lead
Lay summary
Background: Cardio-vascular diseases (CVD), their well established risk factors (CVRF) and mental disorders are common and co-occur more frequently than would be expected by chance. However, the pathogenetic mechanisms and course determinants of both CVD and mental disorders have only been partially identified. In particular, the mechanisms underlying their association still need to be elucidated. Several non-mutually exclusive hypotheses have been suggested to explain this association: a) mental disorders could increase vulnerability to CVD through damaging health behavior including smoking, poor diet, sedentary lifestyle or the side effects of psychotropic drugs; b) CVD or its treatment could promote the development of mental disorders; or c) mental disorders and CVD/CVRF could share pathogenetic mechanisms, such as metabolic processes or genes. The primary aim of the cohort proposal is to follow-up a large population-based sample, which underwent a comprehensive somatic, psychiatric and genetic investigation in order to prospectively assess the complex association between CVD, CVRF and mental disorders. Data collection at follow-up surveys will include: 1) the course of the conditions related to CVD or mental disorders observed at baseline; 2) the incidence of conditions related to CVD or mental disorders during the follow-up; 3) supplementary data on relevant phenotypes that were not part of the baseline investigation; and 4) the evaluation of candidates variables which could be either mediators of a causal relationship or shared factors underlying the association between mental disorders and CVD/CVRF. This list includes biological (genetic, inflammatory, hormonal), clinical (persistent pain, sleep disorders), behavioral (nutrition, physical activity, smoking, alcohol and drug consumption, coping style) and environmental factors (major life-events, social support). The collection of this follow-up information is crucial for the establishment of the dynamic relationship between CVD/CVRF and mental disorders. Specifically, it will allow us to address:Three main study questions: 1) Do mental disorders increase vulnerability to CVRF and CVD? 2) Do CVRF and CVD or their drug treatment promote the development of mental disorders? 3) Do CVRF/CVD and mental disorders share common pathogenetic processes?Methods: The proposal will combine a comprehensive follow-up of CVRF and CVD with a psychiatric exam in all subjects of the original CoLaus sample (n = 6'738) who will participate at the first follow-up (expected n = 6'000 for the somatic and 4'000 for the psychiatric evaluation). The somatic investigation will include a shortened questionnaire on CVRF, CV events and new CVD since baseline and measurements of the same clinical and biological variables in the fasting state as at baseline. Similarly, data on the cause of death will be collected from the Swiss National Death Registry. The comprehensive psychiatric investigation will employ contemporary epidemiological methods. In addition, screening for subjective and objective cognitive impairment will be performed in subjects older than 65 years. Expected value of the project: The combined CoLaus/PsyCoLaus sample provides a unique opportunity to obtain prospective data on the interplay between CVRF/CVD and mental disorders, overcoming limitations of previous research by bringing together a comprehensive investigation of both CVRF and mental disorders as well as a large number of biological variables and a genome-wide genotype assessment in subjects recruited from the general population. With the recent rapid progress in identifying genetic markers for complex diseases, we anticipate that numerous genetic markers for the index diseases in this study can also be used to inform us on the mechanisms of the associations between CVD/CVRF and mental disorders, as well as to predict risk for the development of these conditions.. A better understanding of the psychological, physiological and behavioral links underlying these conditions will result in the development of more specific and efficient strategies of prevention and treatment for both psychiatric and CVD/CVRF, two major elements of burden of disease.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

Employees

Name Institute

Publications

Publication
Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Function
Pattaro Cristian, Köttgen Anna, Teumer Alexander, Garnaas Maija, Böger Carsten A., Fuchsberger Christian, Olden Matthias, Chen Ming-Huei, Tin Adrienne, Taliun Daniel, Li Man, Gao Xiaoyi, Gorski Mathias, Yang Qiong, Hundertmark Claudia, Foster Meredith C., O'Seaghdha Conall M., Glazer Nicole, Isaacs Aaron, Liu Ching-Ti, Smith Albert V., O'Connell Jeffrey R., Struchalin Maksim, Tanaka Toshiko, et al. (2012), Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Function, in PLoS Genetics, 8(3), e1002584-e1002584.
Genome-Wide Association Study to Identify Common Variants Associated with Brachial Circumference: A Meta-Analysis of 14 Cohorts
Boraska Vesna, Day-Williams Aaron, Franklin Christopher S., Elliott Katherine S., Panoutsopoulou Kalliope, Tachmazidou Ioanna, Albrecht Eva, Bandinelli Stefania, Beilin Lawrence J., Bochud Murielle, Cadby Gemma, Ernst Florian, Evans David M., Hayward Caroline, Hicks Andrew A., Huffman Jennifer, Huth Cornelia, James Alan L., Klopp Norman, Kolcic Ivana, Kutalik Zoltán, Lawlor Debbie A., Musk Arthur W., Pehlic Marina, et al. (2012), Genome-Wide Association Study to Identify Common Variants Associated with Brachial Circumference: A Meta-Analysis of 14 Cohorts, in PLoS ONE, 7(3), e31369-e31369.
Not All Inflammatory Markers Are Linked to Kidney Function: Results from a Population-Based Study
Pruijmª Menno, Ponte Belén, Vollenweider Peter, Mooser Vincent, Paccaud Fred, Waeber Gérard, Marques-Vidal Pedro, Burnier Michel, Bochud Murielle (2012), Not All Inflammatory Markers Are Linked to Kidney Function: Results from a Population-Based Study, in American Journal of Nephrology, 35(3), 288-294.
Prevalence, awareness and treatment of type 2 diabetes mellitus in Switzerland: the CoLaus studyType 2 diabetes management in Switzerland
Kaiser A., Vollenweider P., Waeber G., Marques-Vidal P. (2012), Prevalence, awareness and treatment of type 2 diabetes mellitus in Switzerland: the CoLaus studyType 2 diabetes management in Switzerland, in Diabetic Medicine, 29(2), 190-197.
The prevalence and management of cardiovascular risk factors in immigrant groups in Switzerland
Marques-Vidal Pedro, Vollenweider Peter, Waeber Gérard, Paccaud Fred (2012), The prevalence and management of cardiovascular risk factors in immigrant groups in Switzerland, in International Journal of Public Health, 57(1), 63-77.
Hyperhomocysteinemia is independently associated with albuminuria in the population-based CoLaus study
Marti Franziska, Vollenweider Peter, Marques-Vidal Pedro-Manuel, Mooser Vincent, Waeber Gérard, Paccaud Fred, Bochud Murielle (2011), Hyperhomocysteinemia is independently associated with albuminuria in the population-based CoLaus study, in BMC Public Health, 11(1), 733-733.
Prevalence and factors associated with difficulty and intention to quit smoking in Switzerland
Marques-Vidal Pedro, Melich-Cerveira João, Paccaud Fred, Waeber Gérard, Vollenweider Peter, Cornuz Jacques (2011), Prevalence and factors associated with difficulty and intention to quit smoking in Switzerland, in BMC Public Health, 11(1), 227-227.
Dose-dependent positive association between cigarette smoking, abdominal obesity and body fat: cross-sectional data from a population-based survey
Clair Carole, Chiolero Arnaud, Faeh David, Cornuz Jacques, Marques-Vidal Pedro, Paccaud Fred, Mooser Vincent, Waeber Gérard, Vollenweider Peter (2011), Dose-dependent positive association between cigarette smoking, abdominal obesity and body fat: cross-sectional data from a population-based survey, in BMC Public Health, 11(1), 23-23.
Genetic variation at CHRNA5-CHRNA3-CHRNB4 interacts with smoking status to influence body mass index
Freathy R. M., Kazeem G. R., Morris R. W., Johnson P. C. D., Paternoster L., Ebrahim S., Hattersley A. T., Hill A., Hingorani A. D., Holst C., Jefferis B. J., Kring S. I. I., Mooser V., Padmanabhan S., Preisig M., Ring S. M., Sattar N., Upton M. N., Vollenweider P., Waeber G., Sorensen T. I. A., Frayling T. M., Watt G., Lawlor D. A., et al. (2011), Genetic variation at CHRNA5-CHRNA3-CHRNB4 interacts with smoking status to influence body mass index, in International Journal of Epidemiology, 40(6), 1617-1628.
SIRT1 Activates MAO-A in the Brain to Mediate Anxiety and Exploratory Drive
Libert Sergiy, Pointer Kelli, Bell Eric L., Das Abhirup, Cohen Dena E., Asara John M., Kapur Karen, Bergmann Sven, Preisig Martin, Otowa Takeshi, Kendler Kenneth S., Chen Xiangning, Hettema John M., van den Oord Edwin J., Rubio Justin P., Guarente Leonard (2011), SIRT1 Activates MAO-A in the Brain to Mediate Anxiety and Exploratory Drive, in Cell, 147(7), 1459-1472.
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma
Chambers John C, Zhang Weihua, Sehmi Joban, Li Xinzhong, Wass Mark N, Van der Harst Pim, Holm Hilma, Sanna Serena, Kavousi Maryam, Baumeister Sebastian E, Coin Lachlan J, Deng Guohong, Gieger Christian, Heard-Costa Nancy L, Hottenga Jouke-Jan, Kühnel Brigitte, Kumar Vinod, Lagou Vasiliki, Liang Liming, Luan Jian'an, Vidal Pedro Marques, Leach Irene Mateo, O'Reilly Paul F, Peden John F, et al. (2011), Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma, in Nature Genetics, 43(11), 1131-1138.
Association of statins with inflammatory cytokines: A population-based Colaus study
Lyngdoh Tanica, Vollenweider Peter, Waeber Gérard, Marques-Vidal Pedro (2011), Association of statins with inflammatory cytokines: A population-based Colaus study, in Atherosclerosis, 219(1), 253-258.
Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children
Kilpeläinen Tuomas O., Qi Lu, Brage Soren, Sharp Stephen J., Sonestedt Emily, Demerath Ellen, Ahmad Tariq, Mora Samia, Kaakinen Marika, Sandholt Camilla Helene, Holzapfel Christina, Autenrieth Christine S., Hyppönen Elina, Cauchi Stéphane, He Meian, Kutalik Zoltan, Kumari Meena, Stančáková Alena, Meidtner Karina, Balkau Beverley, Tan Jonathan T., Mangino Massimo, Timpson Nicholas J., Song Yiqing, et al. (2011), Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children, in PLoS Medicine, 8(11), e1001116-e1001116.
A Genome-Wide Screen for Interactions Reveals a New Locus on 4p15 Modifying the Effect of Waist-to-Hip Ratio on Total Cholesterol
Surakka Ida, Isaacs Aaron, Karssen Lennart C., Laurila Pirkka-Pekka P., Middelberg Rita P. S., Tikkanen Emmi, Ried Janina S., Lamina Claudia, Mangino Massimo, Igl Wilmar, Hottenga Jouke-Jan, Lagou Vasiliki, van der Harst Pim, Mateo Leach Irene, Esko Tõnu, Kutalik Zoltán, Wainwright Nicholas W., Struchalin Maksim V., Sarin Antti-Pekka, Kangas Antti J., Viikari Jorma S., Perola Markus, Rantanen Taina, Petersen Ann-Kristin, et al. (2011), A Genome-Wide Screen for Interactions Reveals a New Locus on 4p15 Modifying the Effect of Waist-to-Hip Ratio on Total Cholesterol, in PLoS Genetics, 7(10), e1002333-e1002333.
Association between Variants of the Leptin Receptor Gene (LEPR) and Overweight: A Systematic Review and an Analysis of the CoLaus Study
Bender Nicole, Allemann Noëmi, Marek Diana, Vollenweider Peter, Waeber Gérard, Mooser Vincent, Egger Matthias, Bochud Murielle (2011), Association between Variants of the Leptin Receptor Gene (LEPR) and Overweight: A Systematic Review and an Analysis of the CoLaus Study, in PLoS ONE, 6(10), e26157-e26157.
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk
(2011), Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk, in Nature, 478(7367), 103-109.
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure
Wain Louise V, Verwoert Germaine C, O'Reilly Paul F, Shi Gang, Johnson Toby, Johnson Andrew D, Bochud Murielle, Rice Kenneth M, Henneman Peter, Smith Albert V, Ehret Georg B, Amin Najaf, Larson Martin G, Mooser Vincent, Hadley David, Dörr Marcus, Bis Joshua C, Aspelund Thor, Esko Tõnu, Janssens A Cecile J W, Zhao Jing Hua, Heath Simon, Laan Maris, Fu Jingyuan, et al. (2011), Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure, in Nature Genetics, 43(10), 1005-1011.
Association of eGFR-Related Loci Identified by GWAS with Incident CKD and ESRD
Böger Carsten A., Gorski Mathias, Li Man, Hoffmann Michael M., Huang Chunmei, Yang Qiong, Teumer Alexander, Krane Vera, O'Seaghdha Conall M., Kutalik Zoltán, Wichmann H.-Erich, Haak Thomas, Boes Eva, Coassin Stefan, Coresh Josef, Kollerits Barbara, Haun Margot, Paulweber Bernhard, Köttgen Anna, Li Guo, Shlipak Michael G., Powe Neil, Hwang Shih-Jen, Dehghan Abbas, et al. (2011), Association of eGFR-Related Loci Identified by GWAS with Incident CKD and ESRD, in PLoS Genetics, 7(9), e1002292-e1002292.
Genome-wide association study identifies two loci strongly affecting transferrin glycosylation
Kutalik Zoltán, Benyamin Beben, Bergmann Sven, Mooser Vincent, Waeber Gérard, Montgomery Grant W., Martin Nicholas G., Madden Pamela A.F., Heath Andrew C., Beckmann Jacques S., Vollenweider Peter, Marques-Vidal Pedro, Whitfield John B. (2011), Genome-wide association study identifies two loci strongly affecting transferrin glycosylation, in Human Molecular Genetics, 20(18), 3710-3717.
Variant Within the Promoter Region of the CHRNA3 Gene Associated With FTN Dependence Is Not Related to Self-Reported Willingness to Quit Smoking
Marques-Vidal Pedro, Kutalik Zoltán, Paccaud Fred, Bergmann Sven, Waeber Gérard, Vollenweider Peter, Cornuz Jacques (2011), Variant Within the Promoter Region of the CHRNA3 Gene Associated With FTN Dependence Is Not Related to Self-Reported Willingness to Quit Smoking, in Nicotine & Tobacco Research, 13(9), 833-839.
Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile
Kilpeläinen Tuomas O, Zillikens M Carola, Stančákova Alena, Finucane Francis M, Ried Janina S, Langenberg Claudia, Zhang Weihua, Beckmann Jacques S, Luan Jian'an, Vandenput Liesbeth, Styrkarsdottir Unnur, Zhou Yanhua, Smith Albert Vernon, Zhao Jing-Hua, Amin Najaf, Vedantam Sailaja, Shin So-Youn, Haritunians Talin, Fu Mao, Feitosa Mary F, Kumari Meena, Halldorsson Bjarni V, Tikkanen Emmi, Mangino Massimo, et al. (2011), Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile, in Nature Genetics, 43(8), 753-760.
Estimating the Risk of Developing Type 2 Diabetes: A Comparison of Several Risk ScoresThe Cohorte Lausannoise study
Schmid Rémy, Vollenweider Peter, Waeber Gérard, Marques-Vidal Pedro (2011), Estimating the Risk of Developing Type 2 Diabetes: A Comparison of Several Risk ScoresThe Cohorte Lausannoise study, in Diabetes Care, 34(8), 1863-1868.
Novel method to estimate the phenotypic variation explained by genome-wide association studies reveals large fraction of the missing heritability
Kutalik Zoltán, Whittaker John, Waterworth Dawn, Beckmann Jacques S., Bergmann Sven (2011), Novel method to estimate the phenotypic variation explained by genome-wide association studies reveals large fraction of the missing heritability, in Genetic Epidemiology, 35(5), 341-349.
Levels and Determinants of Inflammatory Biomarkers in a Swiss Population-Based Sample (CoLaus Study)
Marques-Vidal Pedro, Bochud Murielle, Bastardot François, Lüscher Thomas, Ferrero François, Gaspoz Jean-Michel, Paccaud Fred, Urwyler Adrian, von Känel Roland, Hock Christoph, Waeber Gérard, Preisig Martin, Vollenweider Peter (2011), Levels and Determinants of Inflammatory Biomarkers in a Swiss Population-Based Sample (CoLaus Study), in PLoS ONE, 6(6), e21002-e21002.
Prevalence of overweight and obesity among migrants in Switzerland: association with country of origin
Marques-Vidal Pedro, Vollenweider Peter, Waeber Gérard, Paccaud Fred (2011), Prevalence of overweight and obesity among migrants in Switzerland: association with country of origin, in Public Health Nutrition, 14(7), 1148-1156.
Elevated Serum Uric Acid Is Associated with High Circulating Inflammatory Cytokines in the Population-Based Colaus Study
Lyngdoh Tanica, Marques-Vidal Pedro, Paccaud Fred, Preisig Martin, Waeber Gérard, Bochud Murielle, Vollenweider Peter (2011), Elevated Serum Uric Acid Is Associated with High Circulating Inflammatory Cytokines in the Population-Based Colaus Study, in PLoS ONE, 6(5), e19901-e19901.
Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption
Schumann G., Coin L. J., Lourdusamy A., Charoen P., Berger K. H., Stacey D., Desrivieres S., Aliev F. A., Khan A. A., Amin N., Aulchenko Y. S., Bakalkin G., Bakker S. J., Balkau B., Beulens J. W., Bilbao A., de Boer R. A., Beury D., Bots M. L., Breetvelt E. J., Cauchi S., Cavalcanti-Proenca C., Chambers J. C., Clarke T.-K., et al. (2011), Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption, in Proceedings of the National Academy of Sciences, 108(17), 7119-7124.
Serum Calcium Levels Are Associated with Novel Cardiometabolic Risk Factors in the Population-Based CoLaus Study
Guessous Idris, Bonny Olivier, Paccaud Fred, Mooser Vincent, Waeber Gérard, Vollenweider Peter, Bochud Murielle (2011), Serum Calcium Levels Are Associated with Novel Cardiometabolic Risk Factors in the Population-Based CoLaus Study, in PLoS ONE, 6(4), e18865-e18865.
CUBN Is a Gene Locus for Albuminuria
Böger Carsten A., Chen Ming-Huei, Tin Adrienne, Olden Matthias, Köttgen Anna, de Boer Ian H., Fuchsberger Christian, O'Seaghdha Conall M., Pattaro Cristian, Teumer Alexander, Liu Ching-Ti, Glazer Nicole L., Li Man, O'Connell Jeffrey R., Tanaka Toshiko, Peralta Carmen A., Kutalik Zoltán, Luan Jian'an, Zhao Jing Hua, Hwang Shih-Jen, Akylbekova Ermeg, Kramer Holly, van der Harst Pim, Smith Albert V., et al. (2011), CUBN Is a Gene Locus for Albuminuria, in Journal of the American Society of Nephrology, 22(3), 555-570.
High expectation in non-evidence-based smoking cessation interventions among smokers—The Colaus study
Marques-Vidal Pedro, Melich-Cerveira João, Paccaud Fred, Waeber Gérard, Vollenweider Peter, Cornuz Jacques (2011), High expectation in non-evidence-based smoking cessation interventions among smokers—The Colaus study, in Preventive Medicine, 52(3-4), 258-261.
Public health impact of statin prescribing strategies based on JUPITER
Nanchen David, Pletcher Mark J., Cornuz Jacques, Marques-Vidal Pedro-Manuel, Paccaud Fred, Waeber Gérard, Vollenweider Peter, Rodondi Nicolas (2011), Public health impact of statin prescribing strategies based on JUPITER, in Preventive Medicine, 52(2), 159-163.
Methods for testing association between uncertain genotypes and quantitative traits
Kutalik Z., Johnson T., Bochud M., Mooser V., Vollenweider P., Waeber G., Waterworth D., Beckmann J. S., Bergmann S. (2010), Methods for testing association between uncertain genotypes and quantitative traits, in Biostatistics, 12(1), 1-17.
FGF21 signalling pathway and metabolic traits – genetic association analysis
Kaess Bernhard M, Barnes Timothy A, Stark Klaus, Charchar Fadi J, Waterworth Dawn, Song Kijoung, Wang William Y S, Vollenweider Peter, Waeber Gerard, Mooser Vincent, Zukowska-Szczechowska Ewa, Samani Nilesh J, Hengstenberg Christian, Tomaszewski Maciej (2010), FGF21 signalling pathway and metabolic traits – genetic association analysis, in European Journal of Human Genetics, 18(12), 1344-1348.
Use of A Mendelian Randomization Approach to Assess the Causal Relation of -Glutamyltransferase with Blood Pressure and Serum Insulin Levels
Conen D., Vollenweider P., Rousson V., Marques-Vidal P., Paccaud F., Waeber G., Bochud M. (2010), Use of A Mendelian Randomization Approach to Assess the Causal Relation of -Glutamyltransferase with Blood Pressure and Serum Insulin Levels, in American Journal of Epidemiology, 172(12), 1431-1441.
Genetic Architecture of Ambulatory Blood Pressure in the General PopulationInsights From Cardiovascular Gene-Centric Array
Tomaszewski Maciej, Debiec Radoslaw, Braund Peter S., Nelson Christopher P., Hardwick Robert, Christofidou Paraskevi, Denniff Matthew, Codd Veryan, Rafelt Suzanne, van der Harst Pim, Waterworth Dawn, Song Kijoung, Vollenweider Peter, Waeber Gerard, Zukowska-Szczechowska Ewa, Burton Paul R., Mooser Vincent, Charchar Fadi J., Thompson John R., Tobin Martin D., Samani Nilesh J. (2010), Genetic Architecture of Ambulatory Blood Pressure in the General PopulationInsights From Cardiovascular Gene-Centric Array, in Hypertension, 56(6), 1069-1076.
Prevalence, treatment and control of dyslipidaemia in Switzerland: still a long way to go
Firmann Mathieu, Marques-Vidal Pedro, Paccaud Fred, Mooser Vincent, Rodondi Nicolas, Waeber Gérard, Vollenweider Peter (2010), Prevalence, treatment and control of dyslipidaemia in Switzerland: still a long way to go, in European Journal of Cardiovascular Prevention & Rehabilitation, 17(6), 682-687.
Alcohol drinking, the metabolic syndrome and diabetes in a population with high mean alcohol consumptionAlcohol, metabolic syndrome and diabetes
Clerc O., Nanchen D., Cornuz J., Marques-Vidal P., Gmel G., Daeppen J.-B., Paccaud F., Mooser V., Waeber G., Vollenweider P., Rodondi N. (2010), Alcohol drinking, the metabolic syndrome and diabetes in a population with high mean alcohol consumptionAlcohol, metabolic syndrome and diabetes, in Diabetic Medicine, 27(11), 1241-1249.
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
Speliotes Elizabeth K, Willer Cristen J, Berndt Sonja I, Monda Keri L, Thorleifsson Gudmar, Jackson Anne U, Allen Hana Lango, Lindgren Cecilia M, Luan Jian'an, Mägi Reedik, Randall Joshua C, Vedantam Sailaja, Winkler Thomas W, Qi Lu, Workalemahu Tsegaselassie, Heid Iris M, Steinthorsdottir Valgerdur, Stringham Heather M, Weedon Michael N, Wheeler Eleanor, Wood Andrew R, Ferreira Teresa, Weyant Robert J, Segrè Ayellet V, et al. (2010), Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index, in Nature Genetics, 42(11), 937-948.
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
Heid Iris M, Jackson Anne U, Randall Joshua C, Winkler Thomas W, Qi Lu, Steinthorsdottir Valgerdur, Thorleifsson Gudmar, Zillikens M Carola, Speliotes Elizabeth K, Mägi Reedik, Workalemahu Tsegaselassie, White Charles C, Bouatia-Naji Nabila, Harris Tamara B, Berndt Sonja I, Ingelsson Erik, Willer Cristen J, Weedon Michael N, Luan Jian'an, Vedantam Sailaja, Esko Tõnu, Kilpeläinen Tuomas O, Kutalik Zoltán, Li Shengxu, et al. (2010), Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution, in Nature Genetics, 42(11), 949-960.
Genetic Variants Influencing Circulating Lipid Levels and Risk of Coronary Artery Disease
Waterworth Dawn M., Ricketts Sally L., Song Kijoung, Chen Li, Zhao Jing Hua, Ripatti Samuli, Aulchenko Yurii S., Zhang Weihua, Yuan Xin, Lim Noha, Luan Jian'an, Ashford Sofie, Wheeler Eleanor, Young Elizabeth H., Hadley David, Thompson John R., Braund Peter S., Johnson Toby, Struchalin Maksim, Surakka Ida, Luben Robert, Khaw Kay-Tee, Rodwell Sheila A., Loos Ruth J.F., et al. (2010), Genetic Variants Influencing Circulating Lipid Levels and Risk of Coronary Artery Disease, in Arteriosclerosis, Thrombosis, and Vascular Biology, 30(11), 2264-2276.
Normal weight obesity: Relationship with lipids, glycaemic status, liver enzymes and inflammation
Marques-Vidal P., Pécoud A., Hayoz D., Paccaud F., Mooser V., Waeber G., Vollenweider P. (2010), Normal weight obesity: Relationship with lipids, glycaemic status, liver enzymes and inflammation, in Nutrition, Metabolism and Cardiovascular Diseases, 20(9), 669-675.
Hundreds of variants clustered in genomic loci and biological pathways affect human height
Lango Allen Hana, Estrada Karol, Lettre Guillaume, Berndt Sonja I., Weedon Michael N., Rivadeneira Fernando, Willer Cristen J., Jackson Anne U., Vedantam Sailaja, Raychaudhuri Soumya, Ferreira Teresa, Wood Andrew R., Weyant Robert J., Segrè Ayellet V., Speliotes Elizabeth K., Wheeler Eleanor, Soranzo Nicole, Park Ju-Hyun, Yang Jian, Gudbjartsson Daniel, Heard-Costa Nancy L., Randall Joshua C., Qi Lu, Vernon Smith Albert, et al. (2010), Hundreds of variants clustered in genomic loci and biological pathways affect human height, in Nature, 467(7317), 832-838.
Metabolically healthy obesity: different prevalences using different criteria
Velho S, Paccaud F, Waeber G, Vollenweider P, Marques-Vidal P (2010), Metabolically healthy obesity: different prevalences using different criteria, in European Journal of Clinical Nutrition, 64(10), 1043-1051.
Biological, clinical and population relevance of 95 loci for blood lipids
Teslovich Tanya M., Musunuru Kiran, Smith Albert V., Edmondson Andrew C., Stylianou Ioannis M., Koseki Masahiro, Pirruccello James P., Ripatti Samuli, Chasman Daniel I., Willer Cristen J., Johansen Christopher T., Fouchier Sigrid W., Isaacs Aaron, Peloso Gina M., Barbalic Maja, Ricketts Sally L., Bis Joshua C., Aulchenko Yurii S., Thorleifsson Gudmar, Feitosa Mary F., Chambers John, Orho-Melander Marju, Melander Olle, Johnson Toby, et al. (2010), Biological, clinical and population relevance of 95 loci for blood lipids, in Nature, 466(7307), 707-713.
Genome-Wide Association Study of Major Recurrent Depression in the U.K. Population
Lewis Cathryn M., Ng Mandy Y., Butler Amy W., Cohen-Woods Sarah, Uher Rudolf, Pirlo Katrina, Weale Michael E., Schosser Alexandra, Paredes Ursula M., Rivera Margarita, Craddock Nicholas, Owen Mike J., Jones Lisa, Jones Ian, Korszun Ania, Aitchison Katherine J., Shi Jianxin, Quinn John P., MacKenzie Alasdair, Vollenweider Peter, Waeber Gerard, Heath Simon, Lathrop Mark, Muglia Pierandrea, et al. (2010), Genome-Wide Association Study of Major Recurrent Depression in the U.K. Population, in American Journal of Psychiatry, 167(8), 949-957.
No interaction between alcohol consumption and HDL-related genes on HDL cholesterol levels
Marques-Vidal Pedro, Bochud Murielle, Paccaud Fred, Waterworth Dawn, Bergmann Sven, Preisig Martin, Waeber Gérard, Vollenweider Peter (2010), No interaction between alcohol consumption and HDL-related genes on HDL cholesterol levels, in Atherosclerosis, 211(2), 551-557.
Opinions on tobacco control policies in Lausanne, Switzerland, 2003–2006
Marques-Vidal Pedro, Melich-Cerveira João, Paccaud Fred, Waeber Gérard, Vollenweider Peter, Cornuz Jacques (2010), Opinions on tobacco control policies in Lausanne, Switzerland, 2003–2006, in Preventive Medicine, 51(2), 193-194.
Genome-Wide Meta-Analysis for Serum Calcium Identifies Significantly Associated SNPs near the Calcium-Sensing Receptor (CASR) Gene
Kapur Karen, Johnson Toby, Beckmann Noam D., Sehmi Joban, Tanaka Toshiko, Kutalik Zoltán, Styrkarsdottir Unnur, Zhang Weihua, Marek Diana, Gudbjartsson Daniel F., Milaneschi Yuri, Holm Hilma, DiIorio Angelo, Waterworth Dawn, Li Yun, Singleton Andrew B., Bjornsdottir Unnur S., Sigurdsson Gunnar, Hernandez Dena G., DeSilva Ranil, Elliott Paul, Eyjolfsson Gudmundur I., Guralnik Jack M., Scott James, et al. (2010), Genome-Wide Meta-Analysis for Serum Calcium Identifies Significantly Associated SNPs near the Calcium-Sensing Receptor (CASR) Gene, in PLoS Genetics, 6(7), e1001035-e1001035.
A Genome-Wide Association Study of Neuroticism in a Population-Based Sample
Calboli Federico C. F., Tozzi Federica, Galwey Nicholas W., Antoniades Athos, Mooser Vincent, Preisig Martin, Vollenweider Peter, Waterworth Dawn, Waeber Gerard, Johnson Michael R., Muglia Pierandrea, Balding David J. (2010), A Genome-Wide Association Study of Neuroticism in a Population-Based Sample, in PLoS ONE, 5(7), e11504-e11504.
Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Liu Jason Z, Tozzi Federica, Waterworth Dawn M, Pillai Sreekumar G, Muglia Pierandrea, Middleton Lefkos, Berrettini Wade, Knouff Christopher W, Yuan Xin, Waeber Gérard, Vollenweider Peter, Preisig Martin, Wareham Nicholas J, Zhao Jing Hua, Loos Ruth J F, Barroso Inês, Khaw Kay-Tee, Grundy Scott, Barter Philip, Mahley Robert, Kesaniemi Antero, McPherson Ruth, Vincent John B, Strauss John, et al. (2010), Meta-analysis and imputation refines the association of 15q25 with smoking quantity, in Nature Genetics, 42(5), 436-440.
Genetic loci influencing kidney function and chronic kidney disease
Chambers John C, Zhang Weihua, Lord Graham M, van der Harst Pim, Lawlor Debbie A, Sehmi Joban S, Gale Daniel P, Wass Mark N, Ahmadi Kourosh R, Bakker Stephan J L, Beckmann Jacqui, Bilo Henk J G, Bochud Murielle, Brown Morris J, Caulfield Mark J, Connell John M C, Cook H Terence, Cotlarciuc Ioana, Smith George Davey, de Silva Ranil, Deng Guohong, Devuyst Olivier, Dikkeschei Lambert D, Dimkovic Nada, et al. (2010), Genetic loci influencing kidney function and chronic kidney disease, in Nature Genetics, 42(5), 373-375.
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge
Saxena Richa, Hivert Marie-France, Langenberg Claudia, Tanaka Toshiko, Pankow James S, Vollenweider Peter, Lyssenko Valeriya, Bouatia-Naji Nabila, Dupuis Josée, Jackson Anne U, Kao W H Linda, Li Man, Glazer Nicole L, Manning Alisa K, Luan Jian'an, Stringham Heather M, Prokopenko Inga, Johnson Toby, Grarup Niels, Boesgaard Trine W, Lecoeur Cécile, Shrader Peter, O'Connell Jeffrey, Ingelsson Erik, et al. (2010), Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge, in Nature Genetics, 42(2), 142-148.
Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1
(2010), Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1, in Nature Genetics, 42(2), 128-131.
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
Dupuis Josée, Langenberg Claudia, Prokopenko Inga, Saxena Richa, Soranzo Nicole, Jackson Anne U, Wheeler Eleanor, Glazer Nicole L, Bouatia-Naji Nabila, Gloyn Anna L, Lindgren Cecilia M, Mägi Reedik, Morris Andrew P, Randall Joshua, Johnson Toby, Elliott Paul, Rybin Denis, Thorleifsson Gudmar, Steinthorsdottir Valgerdur, Henneman Peter, Grallert Harald, Dehghan Abbas, Hottenga Jouke Jan, Franklin Christopher S, et al. (2010), New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk, in Nature Genetics, 42(2), 105-116.
A new highly penetrant form of obesity due to deletions on chromosome 16p11.2
Walters R. G., Jacquemont S., Valsesia A., de Smith A. J., Martinet D., Andersson J., Falchi M., Chen F., Andrieux J., Lobbens S., Delobel B., Stutzmann F., El-Sayed Moustafa J. S., Chèvre J.-C., Lecoeur C., Vatin V., Bouquillon S., Buxton J. L., Boute O., Holder-Espinasse M., Cuisset J.-M., Lemaitre M.-P., Ambresin A.-E., Brioschi A., et al. (2010), A new highly penetrant form of obesity due to deletions on chromosome 16p11.2, in Nature, 463(7281), 671-675.
Clear detection of ADIPOQ locus as the major gene for plasma adiponectin: Results of genome-wide association analyses including 4659 European individuals
Heid Iris M., Henneman Peter, Hicks Andrew, Coassin Stefan, Winkler Thomas, Aulchenko Yurii S., Fuchsberger Christian, Song Kijoung, Hivert Marie-France, Waterworth Dawn M., Timpson Nicholas J., Richards J. Brent, Perry John R.B., Tanaka Toshiko, Amin Najaf, Kollerits Barbara, Pichler Irene, Oostra Ben A., Thorand Barbara, Frants Rune R., Illig Thomas, Dupuis Josée, Glaser Beate, Spector Tim, et al. (2010), Clear detection of ADIPOQ locus as the major gene for plasma adiponectin: Results of genome-wide association analyses including 4659 European individuals, in Atherosclerosis, 208(2), 412-420.
Distribution of plasma levels of adiponectin and leptin in an adult Caucasian populationLeptin and adiponectin in Switzerland
Marques-Vidal Pedro, Bochud Murielle, Paccaud Fred, Mooser Vincent, Waeber Gérard, Vollenweider Peter (2010), Distribution of plasma levels of adiponectin and leptin in an adult Caucasian populationLeptin and adiponectin in Switzerland, in Clinical Endocrinology, 72(1), 38-46.
The PsyCoLaus study: methodology and characteristics of the sample of a population-based survey on psychiatric disorders and their association with genetic and cardiovascular risk factors
Preisig Martin, Waeber Gérard, Vollenweider Peter, Bovet Pascal, Rothen Stéphane, Vandeleur Caroline, Guex Patrice, Middleton Lefkos, Waterworth Dawn, Mooser Vincent, Tozzi Federica, Muglia Pierandrea (2009), The PsyCoLaus study: methodology and characteristics of the sample of a population-based survey on psychiatric disorders and their association with genetic and cardiovascular risk factors, in BMC Psychiatry, 9(1), 9-9.
Genetic evidence for a role of adiponutrin in the metabolism of apolipoprotein B-containing lipoproteins
Kollerits B., Coassin S., Beckmann N. D., Teumer A., Kiechl S., Doring A., Kavousi M., Hunt S. C., Lamina C., Paulweber B., Kutalik Z., Nauck M., van Duijn C. M., Heid I. M., Willeit J., Brandstatter A., Adams T. D., Mooser V., Aulchenko Y. S., Volzke H., Kronenberg F. (2009), Genetic evidence for a role of adiponutrin in the metabolism of apolipoprotein B-containing lipoproteins, in Human Molecular Genetics, 18(23), 4669-4676.
Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution
Lindgren Cecilia M., Heid Iris M., Randall Joshua C., Lamina Claudia, Steinthorsdottir Valgerdur, Qi Lu, Speliotes Elizabeth K., Thorleifsson Gudmar, Willer Cristen J., Herrera Blanca M., Jackson Anne U., Lim Noha, Scheet Paul, Soranzo Nicole, Amin Najaf, Aulchenko Yurii S., Chambers John C., Drong Alexander, Luan Jian'an, Lyon Helen N., Rivadeneira Fernando, Sanna Serena, Timpson Nicholas J., Zillikens M. Carola, et al. (2009), Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution, in PLoS Genetics, 5(6), e1000508-e1000508.
Genome-wide association study identifies eight loci associated with blood pressure
Newton-Cheh Christopher, Johnson Toby, Gateva Vesela, Tobin Martin D, Bochud Murielle, Coin Lachlan, Najjar Samer S, Zhao Jing Hua, Heath Simon C, Eyheramendy Susana, Papadakis Konstantinos, Voight Benjamin F, Scott Laura J, Zhang Feng, Farrall Martin, Tanaka Toshiko, Wallace Chris, Chambers John C, Khaw Kay-Tee, Nilsson Peter, van der Harst Pim, Polidoro Silvia, Grobbee Diederick E, Onland-Moret N Charlotte, et al. (2009), Genome-wide association study identifies eight loci associated with blood pressure, in Nature Genetics, 41(6), 666-676.
Meta-Analysis of 28,141 Individuals Identifies Common Variants within Five New Loci That Influence Uric Acid Concentrations
Kolz Melanie, Johnson Toby, Sanna Serena, Teumer Alexander, Vitart Veronique, Perola Markus, Mangino Massimo, Albrecht Eva, Wallace Chris, Farrall Martin, Johansson Åsa, Nyholt Dale R., Aulchenko Yurii, Beckmann Jacques S., Bergmann Sven, Bochud Murielle, Brown Morris, Campbell Harry, Connell John, Dominiczak Anna, Homuth Georg, Lamina Claudia, McCarthy Mark I., Meitinger Thomas, et al. (2009), Meta-Analysis of 28,141 Individuals Identifies Common Variants within Five New Loci That Influence Uric Acid Concentrations, in PLoS Genetics, 5(6), e1000504-e1000504.

Collaboration

Group / person Country
Types of collaboration
S. Libert, L. Guarente, Massachusetts Institute of Technology, Cambridge United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
C. Kühner, Central Institute of Mental Health, Mannheim Germany (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
I. Barroso, Wellcome Trust Sanger Institute Great Britain and Northern Ireland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Ch. Eap, University Hospital Center of Lausanne, Center of Neuroscience Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
K. Thiveos et al. (FP-7 project) Belgium (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
I. Skoog, Center of Neuropsychiatric Epidemiology, Gothenburg Sweden (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
J. Hettema, Virginia Institute for Psychiatric and Behavioral Genetics, Richmond United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
J. Kooner, National Heart and Lung Institute, Imperial College London Great Britain and Northern Ireland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
O. Devuyst, University of Zürich, Institute of Physiology Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
N. Wareham, University of Cambridge, MRC Epidemiology Unit Great Britain and Northern Ireland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
T. Frayling, Pesinsula Medical School, Exeter Great Britain and Northern Ireland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
B. Hasse, P. Tarr, Swiss HIV cohort, University Hospital of Zürich Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
F. Tozzi, Clinical Sciences - Aptuit Medicines Research Center, Verona Italy (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
A. von Gunten, J. Popp, University Hospital Center of Lausanne, Psychogeriatric service Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
K. Merikangas, National Institute of Health, Genetic Epidemiology Branch, Bethesda United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
D. M. Waterworth, GlaxoSmithKline, medical genetic division, Philadelphia United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
C. Hock, L. Rajendran, Division of Psychiatry Research, Universtiy of Zürich Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
P. McGuffin, King's College, London Great Britain and Northern Ireland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
J-F Démonet, M. Knyazeva, Leenaards Memory Center & LREN, Dpt. of Clinical Neurosciences, CHUV Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
M. Bochud, University Hospital Center of Lausanne, Institute of Social and Preventive Medicine Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
N. Probst, University of Basel, Institute of Social and preventive medicine Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Aubry, J-M, Department of Psychiatry, Universtity of Geneva Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
D. Hans, O. Lamy, University Hospital Center of Lausanne, Bone disease Center Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
B. Draganski, Department of clinical Neurosciences, CHUV, Lausanne Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
M. Tafti, R. Heinzer, CHUV, centre d'Investigation et de Recherche sur le Sommeil Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
18th Annual Conference of the International Society for Bipolar Disorder Talk given at a conference Mental and cardiovascular risk factors across bipolar spectrum disorders in adults 13.07.2016 Amsterdam, Netherlands Preisig Martin;
15th Congress of the International Federation of Psychiatric Epidemiology (IFPE) Talk given at a conference Prospective associations between depression subtypes and inflammatory markers 07.10.2015 Bergen, Norway Preisig Martin;
17th Symposium of the AEP Section Epidemiology and Social Psychiatry Talk given at a conference The role of Inflammatory processes in the prospective association between depression and the components of the metabolic syndrome 21.05.2014 Ulm, Germany Preisig Martin;
7th Biennial Conference of the International Society for Affective Disorders Talk given at a conference The role of Inflammatory processes in the prospective association between depression and the components of the metabolic syndrome 28.04.2014 Berlin, Germany Preisig Martin;
the International Congress of the World Psychiatric Association. Talk given at a conference Prospective association between depression subtypes and the components of the metabolic syndrome in the general population 27.10.2013 Vienne, Austria Preisig Martin;
14th Congress of the International Federation of Psychiatric Epidemiology (IFPE) Talk given at a conference Depression subtypes and the metabolic syndrome: the prospective association and the role of inflammatory processes 05.06.2013 Leipzig, Germany Preisig Martin;
Meeting of the International Group for the Study of Lithium Treated Patients Talk given at a conference Adequate care in bipolar disorder: treatment and health care service utilization data from a population sample 06.09.2012 Berlin, Germany Preisig Martin;
ESC Congress 2012 of the European Society of Cardiology Talk given at a conference Cytokines and hs-CRP levels in individuals treated with aspirin for cardiovascular prevention: a population-based study (CoLaus Study) 25.08.2012 Munich, Germany Vaucher Julien;
6th Biennial Conference of the International Society for Affective Disorders Talk given at a conference Inflammation and depression symptom profile. 18.04.2012 Londres, Great Britain and Northern Ireland Preisig Martin;
20th European Congress of Psychiatry Talk given at a conference Chronic course of depression in the general population. 03.03.2012 Prague, Czech Republic Preisig Martin;
5th Congress of the International Society for Vascular, Cognitive and Behavioral Disorders Talk given at a conference Bipolar disorders and cardio-vascular risk factors: Results of a population-based survey 11.09.2011 Lille, France Preisig Martin;
International Review of Bipolar Disorders Talk given at a conference Bipolar disorders and bipolar spectrum conditions in the community 04.04.2011 Rome, Italy Preisig Martin;
15th Symposium of the AEP Section Epidemiology and Social Psychiatry Talk given at a conference Bipolar disorders and cardio-vascular risk factors: results of a population-based survey 16.06.2010 Bergen, Norway Preisig Martin;
13th Congress of the International Federation of Psychiatric Epidemiology (IFPE) Talk given at a conference Associations between major depressive disorder and risk factors for cardiovascular diseases in a clinical sample and in the general population 16.04.2009 Vienne, Austria Preisig Martin;
the 4th Congress of the International Society for Vascular, Cognitive and Behavioural Disorders Talk given at a conference Associations between mental disorders and risk factors for cardiovascualar diseases 14.01.2009 Singapour, Singapore Preisig Martin;


Awards

Title Year
Biomedical translational research prize of the Leenards Fondation for the project "Les auto-anticorps anti-apoA-1 comme marqueur pronostique du risqué cardiovasculaire et nouvelle cible thérapeutique" 2014

Associated projects

Number Title Start Funding scheme
171352 Age-related renal function decline: a comprehensive study using metabolomic analysis 01.05.2017 Marie Heim-Voegtlin grants
186203 Age-related renal function decline: a comprehensive study using metabolomic analysis 01.05.2019 Marie Heim-Voegtlin grants
156978 Development of an adjustment factor of the ten year probability of fracture (FRAX®) based on an independent bone texture parameter (Trabecular Bone Score) to enhance the detection of patient at risk of fracture: The FRAXOS study 01.11.2014 Project funding (special)
188886 Towards semi-personalized (cluster) medicine with the optimal osteoporotic fracture prediction: artificial intelligence- or current human- based models? The OsteoLaus Project 01.10.2019 Project funding
139468 Cardiovascular diseases and psychiatric disorders in the general population: a prospective follow-up study 01.04.2012 Cohort Studies Large

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