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Cell-Cell Signaling in Morphogenese

English title Cell-Cell Signaling in Morphogenese
Applicant Affolter Markus
Number 122436
Funding scheme Project funding (Div. I-III)
Research institution Abteilung Zellbiologie Biozentrum Universität Basel
Institution of higher education University of Basel - BS
Main discipline Genetics
Start/End 01.12.2008 - 30.11.2011
Approved amount 840'000.00
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Keywords (10)

signaling; transcription; branching morphogenesis; TGFbeta/BMP; cell migration; tubulogenesis; organogenesis; Drosophila; zebrafish; angiogenese

Lay Summary (English)

Lay summary
To understand how shape and size of animal organs are determined and implemented during embryogenesis lies at the heart of developmental biology. We are using Drosophila and zebrafish to decipher the mechanisms controlling organ formation. In order to reach this goal, we combine genetic approaches with live imaging studies, trying to link the function of genes to particular cellular behavior important for organ morphogenesis. We are particularly interested in how secreted substances influence morphogenesis of epithelial organs, or how epithelial organs are restructured during branching morphogenesis to give rise to branched networks. Since we concentrate on angiogenesis processes in the zebrafish system, it is likely that our studies will have implications in the broader field of medecine, in attempts to either increase or decrease the formation of new blood vessels.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants


Associated projects

Number Title Start Funding scheme
138651 Zell Zell Interaktionen in der Morphogenese 01.12.2011 Project funding (Div. I-III)
192659 Drosophila Branching 2.0 01.04.2020 Project funding (Div. I-III)
102112 Zell Zell Interaktionen in der Morphogenese 01.10.2003 Project funding (Div. I-III)