Project

Back to overview

Breastfeeding and the risk of childhood asthma: a population-based study

English title Breastfeeding and the risk of childhood asthma: a population-based study
Applicant Kühni Claudia
Number 122341
Funding scheme Project funding (Div. I-III)
Research institution Institut für Sozial- und Präventivmedizin Universität Bern
Institution of higher education University of Berne - BE
Main discipline Paediatrics
Start/End 01.05.2009 - 31.07.2012
Approved amount 310'076.00
Show all

All Disciplines (4)

Discipline
Paediatrics
Respiratory Diseases
Medical Statistics
Methods of Epidemiology and Preventive Medicine

Keywords (11)

breastfeeding; infant; childhood; preschool; asthma; wheeze; longitudinal studies; prognosis; epidemiology; risk factors; etiology

Lay Summary (English)

Lead
Lay summary
Background: The question whether breastfeeding protects against asthma and allergies is a matter of ongoing debate. Systematic reviews of all research done until 2001 conclude that breastfeeding might have a small protective effect, but stress that overall the evidence is inconclusive because of methodological weaknesses of many studies. Since then, several new publications suggested that breastfeeding might even increase the risk of asthma, especially in children of allergic mothers.Objectives of the planned research: We will conduct a series of studies to describe the effect of breastfeeding on the development of asthma in children.First, we will summarise the results from earlier studies in a systematic review, paying special attention to the methodological quality of studies.Second, we will analyse data from 3,994 children from Leicestershire, UK, who had been followed from birth to the age of 9 years, to determine whether duration of breastfeeding influences the risk of the child to develop asthma. In doing so, we will investigate whether allergy status of the mother and ethnic group affect the results. Third, using data from the same children, we want to find out if breastfeeding influences lung growth, by studying various measures of lung function in children at the age of 10 years, including lung volumes, measures of airway obstruction and measures of alveolar growth. Significance of the research: This project will give a critical summary of the available literature on this topic and will add important new evidence from a large well established cohort study. Analyses will avoid or minimise important methodological pitfalls. In view of the high public health relevance of breastfeeding, and the rising asthma prevalence also in many developing countries, our study is topical and results are likely to inform policy.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

Employees

Publications

Publication
Lung function in the children of immigrant and UK-born south-Asian mothers.
Kuehni Claudia E, Strippoli Marie-Pierre F, Spycher Ben D, Silverman Michael, Beardsmore Caroline S (2015), Lung function in the children of immigrant and UK-born south-Asian mothers., in The European respiratory journal, 45(4), 1163-6.
A simple asthma prediction tool for preschool children with wheeze or cough.
Pescatore Anina M, Dogaru Cristian M, Duembgen Lutz, Silverman Michael, Gaillard Erol A, Spycher Ben D, Kuehni Claudia E (2014), A simple asthma prediction tool for preschool children with wheeze or cough., in The Journal of allergy and clinical immunology, 133(1), 111-118.
Breastfeeding and childhood asthma: systematic review and meta-analysis.
Dogaru Cristian M, Nyffenegger Denise, Pescatore Aniña M, Spycher Ben D, Kuehni Claudia E (2014), Breastfeeding and childhood asthma: systematic review and meta-analysis., in American journal of epidemiology, 179(10), 1153-67.
Copy Number Variation of the Beta-Defensin Genes in Europeans: No Supporting Evidence for Association with Lung Function, Chronic Obstructive Pulmonary Disease or Asthma
Wain Louise V., Odenthal-Hesse Linda, Abujaber Razan, Sayers Ian, Beardsmore Caroline, Gaillard Erol A., Chappell Sally, Dogaru Cristian M., McKeever Tricia, Guetta-Baranes Tamar, Kalsheker Noor, Kuehni Claudia E., Hall Ian P., Tobin Martin D., Hollox Edward J. (2014), Copy Number Variation of the Beta-Defensin Genes in Europeans: No Supporting Evidence for Association with Lung Function, Chronic Obstructive Pulmonary Disease or Asthma, in PLOS ONE, 9(1), e84192.
Increased prevalence of pre-school wheeze is not explained by time trends in body mass index.
Goutaki Myrofora, Pescatore Anina M, Singh Parvinder, Beardsmore Caroline S, Kuehni Claudia E (2014), Increased prevalence of pre-school wheeze is not explained by time trends in body mass index., in The European respiratory journal, 44(4), 1078-82.
Catch-up alveolarization in ex-preterm children: evidence from (3)He magnetic resonance.
Narayanan Manjith, Beardsmore Caroline S, Owers-Bradley John, Dogaru Cristian M, Mada Marius, Ball Iain, Garipov Ruslan R, Kuehni Claudia E, Spycher Ben D, Silverman Michael (2013), Catch-up alveolarization in ex-preterm children: evidence from (3)He magnetic resonance., in American journal of respiratory and critical care medicine, 187(10), 1104-9.
Etiology of Ethnic Differences in Childhood Spirometry
Strippoli Marie-Pierre Françoise, Kuehni Claudia Elisabeth, Dogaru Cristian Mihai, Spycher Ben Daniel, McNally Teresa, Silverman Michael, Beardsmore Caroline Sarah (2013), Etiology of Ethnic Differences in Childhood Spirometry, in Pediatrics, online.
Alveolarization continues during childhood and adolescence: new evidence from helium-3 magnetic resonance.
Narayanan Manjith, Owers-Bradley John, Beardsmore Caroline S, Mada Marius, Ball Iain, Garipov Ruslan, Panesar Kuldeep S, Kuehni Claudia E, Spycher Ben D, Williams Sian E, Silverman Michael (2012), Alveolarization continues during childhood and adolescence: new evidence from helium-3 magnetic resonance., in American journal of respiratory and critical care medicine, 185(2), 186-91.
Breastfeeding and lung function at school age: does maternal asthma modify the effect?
Dogaru Cristian M, Strippoli Marie-Pierre F, Spycher Ben D, Frey Urs, Beardsmore Caroline S, Silverman Michael, Kuehni Claudia E (2012), Breastfeeding and lung function at school age: does maternal asthma modify the effect?, in American journal of respiratory and critical care medicine, 185(8), 874-80.
Exclusive viral wheeze and allergic wheeze: evidence for discrete phenotypes.
Strippoli M-P F, Spycher B D, Pescatore A M, Beardsmore C S, Silverman M, Kuehni C E (2011), Exclusive viral wheeze and allergic wheeze: evidence for discrete phenotypes., in The European respiratory journal : official journal of the European Society for Clinical Respiratory, 38(2), 472-4.
Validation of the Asthma Predictive Index and comparison with simpler clinical prediction rules.
Leonardi Nora A, Spycher Ben D, Strippoli Marie-Pierre F, Frey Urs, Silverman Michael, Kuehni Claudia E (2011), Validation of the Asthma Predictive Index and comparison with simpler clinical prediction rules., in The Journal of allergy and clinical immunology, 127(6), 1466-1466.

Collaboration

Group / person Country
Types of collaboration
University of Leicester Great Britain and Northern Ireland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
European Respiratory Society Annual Congress 2012 Talk given at a conference Does breastfeeding influence development of atopy? A cohort study 02.09.2012 Vienna, Austria Cristian Dogaru; Kühni Claudia;
European Respiratory Society Annual Congress 2012 Poster How do patterns of wheeze change over the first 14 years of life 02.09.2012 Vienna, Austria Strippoli Marie-Pierre; Kühni Claudia;
European Respiratory Society Annual Congress 2012 Poster Multiple trigger and episodic viral wheeze in early childhood: Are these phenotypes stable over time? 02.09.2012 Vienna, Austria Kühni Claudia;
European Respiratory Society Annual Congress 2011 Poster Natural history of chronic non-specific cough in children 24.09.2011 Amsterdam, Netherlands Kühni Claudia; Strippoli Marie-Pierre;
European Respiratory Society Annual Congress 2011 Poster Prediction of later asthma in symptomatic toddlers: a novel approach 24.09.2011 Amsterdam, Netherlands Cristian Dogaru; Kühni Claudia;
European Respiratory Society Annual Congress 2011 Poster Physical activity and asthma symptoms in a population-based cohort 24.09.2011 Amsterdam, Netherlands Strippoli Marie-Pierre; Kühni Claudia; Cristian Dogaru;
European Respiratory Society Annual Congress 2011 Talk given at a conference Early life exposure to locally-generated PM10 and lung function measurements at school-age 24.09.2011 Amsterdam, Netherlands Strippoli Marie-Pierre; Kühni Claudia;
European Respiratory Society Annual Congress 2011 Talk given at a conference Breastfeeding, lung volumes and alveolar size (Oral presentation) 24.09.2011 Amsterdam, Netherlands Strippoli Marie-Pierre; Kühni Claudia; Cristian Dogaru;
European respiratory Society Annual Congress 2010 Poster Association between breastfeeding and  lung function in childhood 18.09.2010 Barcelona, Spain Kühni Claudia; Strippoli Marie-Pierre; Cristian Dogaru; Egger Matthias; Frey Urs;
European respiratory Society Annual Congress 2010 Talk given at a conference Phenotypes of childhood wheeze and cough: can they be identified from epidemiological data? 18.09.2010 Barcelona, Spain Strippoli Marie-Pierre; Kühni Claudia;
European respiratory Society Annual Congress 2010 Poster Paracetamol, non-steroidal anti-inflammatory drugs and risk of asthma in adult survivors of childhood cancer 18.09.2010 Barcelona, Spain Kühni Claudia; Strippoli Marie-Pierre;
European respiratory Society Annual Congress 2010 Poster Impact of early life parental smoking on acinar airway inhomogeneity 18.09.2010 Barcelona, Spain Cristian Dogaru; Kühni Claudia;
European respiratory Society Annual Congress 2010 Poster Conductive and acinar ventilation inhomogeneity by nitrogen washout in healthy children 18.09.2010 Barcelona, Spain Kühni Claudia;
European respiratory Society Annual Congress 2010 Poster Does the difference in lung function between UK-born south Asian and white children diminish with successive generations since immigration? 18.09.2010 Barcelona, Spain Strippoli Marie-Pierre; Kühni Claudia;
European respiratory Society Annual Congress 2010 Talk given at a conference Validating of the Tucson asthma predictive index in an independent cohort 18.09.2010 Barcelona, Spain Kühni Claudia;
European respiratory Society Annual Congress 2010 Poster Early life parental smoking is associated with enlarged alveoli in later childhood: Evidence from 3-helium magnetic resonance 18.09.2010 Barcelona, Spain Kühni Claudia; Cristian Dogaru;
European respiratory Society Annual Congress 2010 Poster Triggers of wheeze in 1-9 year old children: evidence for independent mechanisms? 18.09.2010 Barcelona, Spain Strippoli Marie-Pierre; Kühni Claudia;
European Respiratory Society Annual Congress 2009 Talk given at a conference Paediatric respiratory epidemiology year in review if yes: how many, and which? 12.09.2009 Vienna, Austria Kühni Claudia;
European Respiratory Society Annual Congress 2009 Talk given at a conference Evidence for Continuous Alveolisation in Childhood using 3He Magnetic Resonance 12.09.2009 Vienna, Austria Kühni Claudia;
European Respiratory Society Annual Congress 2009 Talk given at a conference Paracetamol use and the risk of wheeze: causation or bias? 12.09.2009 Vienna, Austria Kühni Claudia; Strippoli Marie-Pierre;
European Respiratory Society Annual Congress 2009 Poster Childhood wheeze: one or several diseases? 12.09.2009 Vienna, Austria Kühni Claudia; Strippoli Marie-Pierre;
European Respiratory Society Annual Congress 2009 Poster Early daycare and the risk of wheeze from 1 to 8 years 12.09.2009 Vienna, Austria Strippoli Marie-Pierre; Kühni Claudia;


Communication with the public

Communication Title Media Place Year
New media (web, blogs, podcasts, news feeds etc.) Should asthmatic mothers nurse their babies? German-speaking Switzerland International 2012
New media (web, blogs, podcasts, news feeds etc.) Should Mothers with Asthma Nurse Their Babies? International 2012
New media (web, blogs, podcasts, news feeds etc.) European involvement International 2011
New media (web, blogs, podcasts, news feeds etc.) Facebook and Twitter communities-Join us! International 2011
New media (web, blogs, podcasts, news feeds etc.) Predicting asthma in young children International 2011
New media (web, blogs, podcasts, news feeds etc.) The 2010-2011 survey is ongoing International 2011
New media (web, blogs, podcasts, news feeds etc.) The Leicestershire Study School-Successful completion! International 2011
New media (web, blogs, podcasts, news feeds etc.) The Lung Development Study International 2011
New media (web, blogs, podcasts, news feeds etc.) Phenotypes of asthma International 2010
New media (web, blogs, podcasts, news feeds etc.) The Leicestershire School Study-Completion by July 2010 International 2010

Associated projects

Number Title Start Funding scheme
162820 Phenotypes and prognostic modelling in childhood asthma: moving towards clinical applications 01.10.2015 Project funding (Div. I-III)
144068 Breastfeeding and respiratory outcomes from infancy to school-age: pathways and temporal sequence 01.10.2012 Project funding (Div. I-III)
137033 Defining phenotypes and risk factors of chronic non-specific cough in children 01.10.2012 ProDoc

-