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Second-line regimens after treatment failure in HIV-infected patients in resource-constrained settings: a multicentre collaborative study

English title Second-line regimens after treatment failure in HIV-infected patients in resource-constrained settings: a multicentre collaborative study
Applicant Calmy Alexandra
Number 122116
Funding scheme Project funding (special)
Research institution Département Médecine interne HUG
Institution of higher education University of Geneva - GE
Main discipline Infectious Diseases
Start/End 01.10.2008 - 30.09.2009
Approved amount 96'106.00
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Keywords (6)

HIV; resource-limited; antiretroviral therapy; second-line therapy; large nested project; Swiss HIV Cohort Study

Lay Summary (English)

Lead
Lay summary
Background: in industrialized countries, the prognosis of HIV infection has improved considerably since the advent of highly active antiretroviral therapy (ART) in 1996. In lower-income countries with a high burden of HIV/AIDS, ART has become more widely available only in recent years. Most of the time however, patients are maintained in a first line regimen unless a clinical event trigger a switch to a subsequent new so-called second line regimen. With increased exposure to ART, the risk of resistance and subsequent treatment failure is rising.Aim: this study aims to analyse a combined dataset based on two large collaborations of ART treatment programmes in lower income settings, the ART-LINC collaboration and Médecins sans Frontières (MSF); we aim at determining the rates and determinants of switching to second-line regimens and at comparing clinical and biological outcomes between patients who switched and patients who did not switch to a second line regimen. Significance: This project provides a unique opportunity to study antiretroviral treatment outcomes on second-line ART in various treatment programmes in lower income settings. Because of its very large sample size (more than 100’000 patients will be included), we will be able to investigate patients and sites with different characteristics, and therefore be able to generalize our findings. The results are likely to contribute significantly to the ongoing debate on second-line ART in resource-limited settings and inform policy makers on the critical actions that should be taken to allow more patients to benefit from an efficient second-line HIV therapy.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

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Associated projects

Number Title Start Funding scheme
131629 Long-term antiretroviral therapy of HIV-infected patients in sub-Saharan Africa - insights from causal and mathematical modelling 01.01.2011 Ambizione

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