Cancer; Single-Molecule Magnets; Chemotherapy; Quantum-Based Computing
Zobi Fabio Blacque Olivier Jacobs Robert A. Schaub Marcus C. Bogdanova Anna Yu. (2012), 17 e− rhenium dicarbonyl CO-releasing molecules on a cobalamin scaffold for biological application, in Dalton Transactions
, 41, 370-378.
Zobi Fabio Splingler Bernhard (2012), Post-Protein-Binding Reactivity and Modifications of the fac-[Re(CO)3]+ Core, in Inorganic Chemistry
, Article ASAP (available online), ASAP-ASAP.
Zobi Fabio Blacque Olivier (2011), Reactivity of 17e- Complex [ReIIBr4(CO)2]2- with Bridging Aromatic Ligands. Characterization and CO-Releasing Properties, in Dalton Transactions
, 40, 4994-5001.
Zobi Fabio (2010), A Different ‘Spin’ on Rhenium Chemistry. Synthetic Approaches and Perspectives of 17-Electron Rhenium Complexes, in Chimia
, 64, 259-265.
Zobi Fabio Degonda Alois Schaub Marcus C. Bogdanova Anna Yu. (2010), CO Releasing Properties and Cytoprotective Effect of cis-trans-[ReII(CO)2Br2L2]n Complexes, in Inorganic Chemistry
, 49, 7313-7322.
Zobi Fabio Degonda Alois (2010), CO Releasing Properties of cis-trans-[ReII(CO)2Br2L2]n Complexes, in Nuclear Medicine and Biology
, 37, 712-712.
Zobi Fabio (2010), Ligand Electronic Parameters as a Measure of the Polarization of C≡O Bond in [M(CO)xLy]n Complexes and of the Relative Stabilization of [M(CO)xLy]n/n+1 Species, in Inorganic Chemistry
, 49, 10370-10377.
Zobi Fabio Alberto Roger (2010), Redox Induced Binding of [(tacn)ReIIBr(CO)2]+ to Guanine, Oligonucleotides and Peptides, in Chemistry a European Journal
, 16, 2710-2713.
Zobi Fabio Spingler Bernhard Alberto Roger (2009), Formation and Reactivity of [(tacn)-N-CO-ReIIIBr(CO)2]+ in Water: a Theoretical and Experimental Study, in Inorganic Chemistry
, 48, 4963-4970.
Zobi Fabio (2009), Parametrization of the Contribution of Mono- and Bidentate Ligands on the Symmetric C=O Stretching Frequency of fac-[Re(CO)3]+ Complexes, in Inorganic Chemistry
, 48, 10845-10855.
Zobi Fabio Kromer Lukas Spingler Bernhard Alberto Roger (2009), Synthesis and Reactivity of the 17 e- Complex [ReIIBr4(CO)2]2-: A Convenient Entry into Rhenium(II) Chemistry, in Inorganic Chemistry
, 48, 8965-8970.
Santoro Giuseppe Blacque Olivier Zobi Fabio, Post-Protein-Binding Metal-Mediated Coupling of an Acridine Orange-Based Fluorophore, in Metallomics
Rhenium (II) chemistry is rare. There is no systematic synthetic strategy to Re(II) precursors. Rhenium (II) compounds, however, are particularly attractive from a medicinal inorganic chemistry point of view (specially as Tc congeners) and (as recently demonstrated) as precursors for single-molecule magnetic clusters. Besides our compounds to be described later in this proposal, our research group has recently introduced substitution labile Re(II) compounds of the form [ReBr3(NCCH3)(CO)2]-. These compounds enable a systematic study of complexes comprising the cis-[ReII(CO)2]2+ core with various ligands for medicinal and supramolecular studies. Furthermore and of high relevance for this proposal, we recently discovered a synthetic method (henceforth called “ligand-mediated decarbonylation” LMD) which allowed the systematic synthesis of rare Re(II)-based complexes starting from common and easily accessible fac-ReI(CO)3 species in high yields.On this base, the objectives of this proposal can be summarized as follows:1.Explore Re(II) chemistry starting from synthons comprising the “fac-[(N3)Re]2+“ or the cis-[ReII(CO)2]2+ core.2.Generalize the LMD reaction to other amine-based ligands3.Investigate the action of specially designed Re(II) complexes with biologically relevant molecules such as DNA 4.Introduce bridging ligands such as cyanide into the building blocks received under 1 for building up supramolecular structures for single molecular magnetsWe argue that systematic synthetic methods to Re(II) complexes represent an important leap forward in the field of rhenium chemistry, opening new horizons in basic chemistry, technology, application and scholarship. The proposal describes an undisclosed synthetic method to unique Re(II) complexes and the directions we intend to pursue for applications of these species.