Project

Back to overview

Neue antibakterielle Oberflächen auf Implantat- Materialien

English title New Anti-Bacterial Coatings for Implant Materials
Applicant Fromm Katharina M.
Number 121813
Funding scheme Project funding (Div. I-III)
Research institution Département de Chimie Université de Fribourg
Institution of higher education University of Fribourg - FR
Main discipline Organic Chemistry
Start/End 01.10.2008 - 30.09.2011
Approved amount 478'655.00
Show all

All Disciplines (2)

Discipline
Organic Chemistry
Biomedical Engineering

Keywords (9)

Implant Materials; Surface Coatings; Anti-microbial properties; biofilm formation; prosthetic joint infection; nano- and microcalorimetry; antimicrobial coatings; silver coordination chemistry; in vitro and in vivo tests

Lay Summary (English)

Lead
Lay summary
In all European countries, devices are increasingly inserted in patients to relieve pain or improve function or for esthetic reasons. These implants can be foci for infection, which still represents one of the most serious and devastating complications, forcing patients back to surgery for infection control and/or implant replacement. In this context the development of new bioactive surfaces, aimed to reduce the high vulnerability of the interstitial milieu between implant and surrounding tissue, has a large impact on a growing medical problem, quality of patient life, and an opportunity for the production of new marketable technologies.In this interdisciplinary research project, we plan i) the synthesis of new silver coordination compounds, including complexes of Ag+ with antibiotics, ii) to test bacterial strains with and without biofilms for completeness, iii) to make systematic investigations on the mechanism of action of the compounds on the bacteria, using mutants as well as different screening methods such as agarose plates, confocal microscopy, micro- and nano-calorimetry and iv) in vivo studies of our promising candidates giving insights into real-life measurements, pharmaco-kinetics, and biocompatibility. To realize this project, we propose an interdisciplinary research team consisting of a chemist (synthesis and analysis), a material scientist (biomechanics, calorimetry), a microbiologist/infectious diseases specialist (in vitro and animal studies) and an orthopedic surgeon (in vitro).
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

Employees

Publications

Publication
Silver coordination polymers for prevention of implant infection: Thiol interaction, impact on respiratory chain enzymes, and hydroxyl radical induction
Gordon O, Slenters TV, Brunetto PS, Villaruz AE, Sturdevant DE, Otto M, Landmann R, Fromm KM (2010), Silver coordination polymers for prevention of implant infection: Thiol interaction, impact on respiratory chain enzymes, and hydroxyl radical induction, in Antimicrobial Agents and Chemotherapy, 54(10), 4208-4218.
Silver nanoparticle formation in different sizes induced by peptides identified within split-and-mix libraries
Belser K, Slenters TV, Pfumbidzai C, Upert G, Mirolo L, Fromm KM, Wennemers H (2009), Silver nanoparticle formation in different sizes induced by peptides identified within split-and-mix libraries, in Angewandte Chemie - International Edition, 48(20), 3661-3664.
Antimicrobial coatings for implant surfaces
Brunetto PS, Fromm KM (2008), Antimicrobial coatings for implant surfaces, in Chimia, 62(4), 249-252.
Combating implant infections. Remarks by a women's team
Arciolai CR, Balaban N, Baldassarri L, Fromm K, Hansch GM, Obst U, Presterl E, Stefani S, Verran J, Visai L (2008), Combating implant infections. Remarks by a women's team, in INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS, 31(9), 858-864.
Silver coordination compounds as light-stable, nano-structured and anti-bacterial coatings for dental implant and restorative materials
Slenters TV, Hauser-Gerspach I, Daniels AU, Fromm KM (2008), Silver coordination compounds as light-stable, nano-structured and anti-bacterial coatings for dental implant and restorative materials, in Journal of Materials Chemistry, 18(44), 5359-5362.

Awards

Title Year
Doktorandenpreis der CUSO in Chemie 2009

Associated projects

Number Title Start Funding scheme
128686 Towards a more bulk sensitive photoemission experiment 01.06.2010 R'EQUIP
138122 New anti-bacterial coatings for implant materials 01.10.2011 Project funding (Div. I-III)
139147 R'Equip grant proposal for a MALDI ToF mass spectrometer 01.04.2012 R'EQUIP
137362 SupraChem@Balkans.eu : Supramolecular training for students and young researchers in the Balkan area 01.01.2012 SCOPES
139226 IncuCyte-based high throughput imaging-based platform for determination of cellular and molecular events in real time in cultured cells in vitro: application to nanomaterial studies, cancer and cardiovascular research 01.12.2011 R'EQUIP
114149 Neue antibakterielle Oberflächen auf Implantat- Materialien 01.10.2006 Project funding (Div. I-III)
138122 New anti-bacterial coatings for implant materials 01.10.2011 Project funding (Div. I-III)

-