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The role of humoral immunity in HIV infection

English title The role of humoral immunity in HIV infection
Applicant Trkola Alexandra
Number 120739
Funding scheme Project funding
Research institution Abteilung für Infektionskrankheiten Universitätsspital
Institution of higher education University of Zurich - ZH
Main discipline Clinical Immunology and Immunopathology
Start/End 01.04.2008 - 31.03.2011
Approved amount 510'000.00
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Keywords (3)

humoral immune response; neutralization; HIV

Lay Summary (English)

Lead
Lay summary
In the present proposal we aim to unravel mechanistic aspects of the humoral immune response in HIV infection to define if and which responses should be elicited by a successful vaccine regimen. We seek to define if neutralization of free virus is the sole effective antiviral activity of the humoral immune response in vivo or if antibodies against HIV also act through effector mechanisms of the immune system by inducing action of the complement system, killer cells or phagocytes. We will study how neutralizing antibodies mediate their antiviral activity in vivo, how they interfere with different modes of viral dissemination in tissue and which epitopes the neutralizing antibody response elicited in vivo recognizes. Lastly, we will investigate how virus escapes neutralizing antibodies and, in turn, the immune system adapts to the emerged viral variants to derive a more complete understanding of the interplay between virus and host immune system.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

Employees

Associated projects

Number Title Start Funding scheme
135527 The role of humoral immunity in HIV infection 01.04.2011 Project funding
172790 Understanding HIV-1 broadly neutralizing antibody evolution - The Swiss 4.5K Screen 01.04.2017 Project funding (special)
102647 HIV entry: a target for the host immune response and antiviral approaches 01.03.2004 SNSF Professorships

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