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Prize Reinforcement Contingency Management for Cocaine Dependence: a 24-week randomized controlled trial

Applicant Petitjean Sylvie
Number 120675
Funding scheme Project funding (Div. I-III)
Research institution Psychiatrische Klinik Universitäre Psychiatrische Kliniken UPK
Institution of higher education University of Basel - BS
Main discipline Psychology
Start/End 01.09.2008 - 31.10.2014
Approved amount 496'954.00
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All Disciplines (2)

Discipline
Psychology
Neurology, Psychiatry

Keywords (15)

randomized controlled trial; cocaine dependence; contingency management; cognitive behavioral therapy; clinical trial; prize-based; cognitive-behavioral therapy; cocaine abuse; substance abuse; treatment outcome; Cocaine Dependence; Contingency Management; Cognitive Behavioral Therapy; Randomized Controlled Trial; Substance Use Disorders

Lay Summary (English)

Lead
Lay summary
Some epidemiological data indicate a rising cocaine use in Switzerland. The latest report by the United Nations Office for Drugs and Crime (2007) showed overall highest levels of cocaine consumption in the United States (U.S.), followed by Spain, Italy, UK and Switzerland based on waste-water analysis. Total costs from drug use are estimated at 1412 millions per year in Switzerland and of concern for Public Health authorities. The increase of cocaine use has recently led to the need to develop appropriate treatments in patients with cocaine abuse and dependence. Until now no pharmacotherapy has been found to treat cocaine dependence effectively. However, there is an extensive body of clinical evidence in the U.S. showing that programs based on Contingency management (CM) ore prize-based CM are effective in the treatment of substance use disorders, especially in improving treatment outcomes in cocaine-dependent patients. CM is a strategy that provides reinforcing consequences when patients meet treatment goals (e.g. abstinence). Results from a series of randomized trials demonstrated that a combined type of treatment intervention (Cognitive Behavioral Interventions [e.g. CBT] plus prize-based CM) produced significantly better treatment outcomes as compared to drug counseling, CBT alone or vouchers only. Currently prize-based CM as a treatment model has not been implemented in addiction research or in clinical outpatient settings in Europe or in Switzerland, with only one exception, a recently published randomized controlled trial from Spain (2007). Nevertheless, because there are virtually no performed controlled trials with cocaine-dependent individuals performed outside of the US, further research is needed for the generalizability of the CBT plus prize-based CM in beyond that country. The purpose of this study is to analyze the efficacy (cocaine abstinence) and acceptability of an individual Cognitive Behavioral Therapy (CBT) combined with prize-reinforcement CM in two outpatient addiction clinics in Switzerland (Basel and Geneva). In a parallel groups design we will randomly assign cocaine-dependent patients to prize reinforcement CM combined with individual CBT or to individual CBT alone. After a 2-week intake phase, eligible patients will be randomly assigned to one of the two interventions for 12 weeks, followed by a 12 weeks maintenance period. Urine samples will be collected over the total study period of 24 weeks. Patients in the CBT + prize reinforcement CM condition will have the chance to earn prizes throughout the total study period of different magnitudes (‘mini’, ‘medium’ and ‘jumbo prizes’) for submitting cocaine negative urine samples. The chance of winning prizes will increase with continuous time abstinence. Patients in the CBT condition will get no prizes at all. Primary (efficacy) outcomes are the proportion of cocaine-positive samples at different endpoints (4, 12, 24 weeks, and at 6 month follow-up), weeks of continuous cocaine abstinence, self-reported drug use, and number of dropouts. Secondary outcomes are patients’ rating about satisfaction with the interventions and changes in important life areas.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

Employees

Publications

Publication
A randomized, controlled trial of combined cognitive-behavioral therapy plus prize-based contingency management for cocaine dependence
Petitjean Sylvie (2014), A randomized, controlled trial of combined cognitive-behavioral therapy plus prize-based contingency management for cocaine dependence, in Drug and Alcohol Dependence, 145, 94-100.
A systematic Review Comparing Cognitive-Behavioral Therapy and Contingency Management in Cocaine Dependence
Farronato Nadine, Petitjean Sylvie (2013), A systematic Review Comparing Cognitive-Behavioral Therapy and Contingency Management in Cocaine Dependence, in Journal of Addictive Diseases, 32(3), 274-287.
Therapiemanual Kokainabhängigkeit
Dürsteler-MacFarland Kenneth M., Schmid Otto, Strasser Johannes, Wiesbeck Gerhard A. (2010), Therapiemanual Kokainabhängigkeit.

Collaboration

Group / person Country
Types of collaboration
Prof. Cathleen Carroll; Yale School of Medicine, Westhaven CT United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
Prof. Nancy Petry; University of Connecticut United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
- Publication

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
43rd Annual Congress of the European Association for Behavioural and Cognitive Therapies Talk given at a conference Prize Reinforcement Contingency Management for Cocaine Dependence: a Swiss 24-week randomized controlled trial. Preliminary Results 25.09.2013 Marrakech, Morocco Croquette Marina; Petitjean Sylvie;
Swiss Addiction Research Day VI, Swiss Society of Addiction Medicine (SSAM) Talk given at a conference Prize Reinforcement Contingency Management for Cocaine Dependence: a 24-week randomized controlled trial. Preliminary Results 13.09.2013 Montreux, Switzerland Wiesbeck Gerhard; Farronato Nadine; Dürsteler Kenneth; Petitjean Sylvie;
14th annual meeting of the International Society of Addiction Medicine: Young Investigator Symposium: Predictors of treatment dropout in cocaine-dependent patients Talk given at a conference Predictors of treatment dropout in cocaine-dependent patients 15.10.2012 Genf, Schweiz, Switzerland Croquette Marina; Dürsteler Kenneth; Wiesbeck Gerhard; Petitjean Sylvie; Farronato Nadine;
10th European and International Colloque of Toxicomanie, Hépatites, SIDA (THS) Talk given at a conference Prize Reinforcement Contingency Management for Cocaine Dependence 11.10.2011 Biarritz, France Petitjean Sylvie; Croquette Marina;
DGPPN Kongress: Prize Reinforcement Contingency Management for Cocaine Dependence (Poster). Poster Prize Reinforcement Contingency Management for Cocaine Dependence 26.11.2010 Berlin, Germany Müller Sandra; Degen Bigna; Farronato Nadine; Trombini Mauro; Wiesbeck Gerhard;
Meeting of the Swiss Society of Biological Psychiatry (SSBP): Prize Reinforcement Contingency Management for Cocaine Dependence (Poster). Poster Prize Reinforcement Contingency Management for Cocaine Dependence 18.03.2010 Zürich, Switzerland Croquette Marina; Wiesbeck Gerhard; Farronato Nadine; Degen Bigna; Petitjean Sylvie; Dürsteler Kenneth;
Swiss Addiction Research Day der Swiss Society of Addiction Medicine (SSAM): Prize Reinforcement Contingency Management for Cocaine Dependence. Talk given at a conference Prize Reinforcement Contingency Management for Cocaine Dependence 13.11.2009 Basel, Switzerland Croquette Marina; Dürsteler Kenneth; Farronato Nadine; Petitjean Sylvie;
Swiss Addiction Research Day der Swiss Society of Addiction Medicine (SSAM): Prize Reinforcement Contingency Management for Cocaine Dependence (Poster). Poster Prize Reinforcement Contingency Management for Cocaine Dependence 13.11.2009 Basel, Switzerland Petitjean Sylvie; Trombini Mauro; Wiesbeck Gerhard; Farronato Nadine; Dürsteler Kenneth; Degen Bigna;


Self-organised

Title Date Place
6. Basler Frühjahrstagung der UPK Basel: Kognitive Verhaltenstherapie bei kokainbedingten Störungen. 07.05.2010 Universitären Psychiatrischen Kliniken Basel , Switzerland

Knowledge transfer events

Active participation

Title Type of contribution Date Place Persons involved
Neue Behandlungsmöglichkeiten bei Problemen mit Kokain 16.12.2010 Basel, Switzerland Farronato Nadine; Petitjean Sylvie;


Communication with the public

Communication Title Media Place Year
Media relations: print media, online media Jahresbericht Fondation Phénix: Rapport annuel 2012 Webseite Western Switzerland 2013
Media relations: print media, online media Gut integriert und doch süchtig Basler Zeitung German-speaking Switzerland 2011
Media relations: radio, television „Neue Behandlungsmethoden der Kokainabhängigkeit“ RadioBasel German-speaking Switzerland 2010

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