tuberculosis; virulence; phagosome maturation; lipoprotein; secretion
Widdick David A., Hicks Matthew G., Thompson Benjamin J., Tschumi Andreas, Chandra Govind, Sutcliffe Iain C., Bruelle Juliane K., Sander Peter, Palmer Tracy, Hutchings Matthew I. (2011), Dissecting the complete lipoprotein biogenesis pathway in Streptomyces scabies, in
MOLECULAR MICROBIOLOGY, 80(5), 1395-1412.
Johansen Pal, Fettelschoss Antonia, Amstutz Beat, Selchow Petra, Waeckerle-Men Ying, Keller Peter, Deretic Vojo, Held Leonhard, Kuendig Thomas M., Boettger Erik C., Sander Peter (2011), Relief from Zmp1-Mediated Arrest of Phagosome Maturation Is Associated with Facilitated Presentation and Enhanced Immunogenicity of Mycobacterial Antigens, in
CLINICAL AND VACCINE IMMUNOLOGY, 18(6), 907-913.
Joller Nicole, Weber Stefan S., Mueller Andreas J., Spoerri Roman, Selchow Petra, Sander Peter, Hilbi Hubert, Oxenius Annette (2010), Antibodies protect against intracellular bacteria by Fc receptor-mediated lysosomal targeting, in
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 107(47), 20441-20446.
Bruelle Juliane K., Grau Thomas, Tschumi Andreas, Auchli Yolanda, Burri Reto, Polsfuss Silke, Keller Peter M., Hunziker Peter, Sander Peter (2010), Cloning, expression and characterization of Mycobacterium tuberculosis lipoprotein LprF, in
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 391(1), 679-684.
Imkamp Frank, Rosenberger Tobias, Striebel Frank, Keller Peter M., Amstutz Beat, Sander Peter, Weber-Ban Eilika (2010), Deletion of dop in Mycobacterium smegmatis abolishes pupylation of protein substrates in vivo, in
MOLECULAR MICROBIOLOGY, 75(3), 744-754.
Imkamp Frank, Striebel Frank, Sutter Markus, Oezcelik Dennis, Zimmermann Natalie, Sander Peter, Weber-Ban Eilika (2010), Dop functions as a depupylase in the prokaryotic ubiquitin-like modification pathway, in
EMBO REPORTS, 11(10), 791-797.
Tschumi Andreas, Nai Corrado, Auchli Yolanda, Hunziker Peter, Gehrig Peter, Keller Peter, Grau Thomas, Sander Peter (2009), Identification of Apolipoprotein N-Acyltransferase (Lnt) in Mycobacteria, in
JOURNAL OF BIOLOGICAL CHEMISTRY, 284(40), 27146-27156.
Walch Michael, Rampini Silvana K., Stoeckli Isabelle, Latinovie-Golic Sonja, Dumrese Claudia, Sundstrom Hanna, Vogetseder Alexander, Marino Joseph, Glauser Daniel L., van den Broek Maries, Sander Peter, Groscurth Peter, Ziegler Urs (2009), Involvement of CD252 (CD134L) and IL-2 in the Expression of Cytotoxic Proteins in Bacterial- or Viral-Activated Human T Cells, in
JOURNAL OF IMMUNOLOGY, 182(12), 7569-7579.
Guo Ying Lan, Mayer Hermann, Vollmer Waldemar, Dittrich Dorothea, Sander Peter, Schultz Anita, Schultz Joachim E. (2009), Polyphosphates from Mycobacterium bovis- potent inhibitors of class III adenylate cyclases, in
FEBS JOURNAL, 276(4), 1094-1103.
Weber Wilfried, Schoenmakers Ronald, Keller Bettina, Gitzinger Marc, Grau Thomas, Baba Marie Daoud-El, Sander Peter, Fussenegger Martin (2008), A synthetic mammalian gene circuit reveals antituberculosis compounds, in
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105(29), 9994-9998.
Rampini Silvana K., Selchow Petra, Keller Christine, Ehlers Stefan, Boettger Erik C., Sander Peter (2008), LspA inactivation in Mycobacterium tuberculosis results in attenuation without affecting phagosome maturation arrest, in
MICROBIOLOGY-SGM, 154, 2991-3001.
Keller Peter M., Boettger Erik C., Sander Peter (2008), Tuberculosis vaccine strain Mycobacterium bovis BCG Russia is a natural recA mutant, in
BMC MICROBIOLOGY, 8, 120.
Lipoproteins: Synthesis, localization and function in mycobacteriaMycobacterium tuberculosis is still a major threat in our days claiming annually 1.7 million deaths worldwide. A better understanding of M. tuberculosis, its biology and host-pathogen interaction is required for rational approaches to combat this deadly disease and for the development of novel drugs and innovative vaccines. The submitted research proposal focuses on two aspects: 1. lipoprotein synthesis, localization and function, 2. phagosome maturation arrest and intracellular survival. We will combine genetic and biochemical investigations and perform virulence assays along with cell biology and physiological studies a) to characterize genes of the lipoprotein synthesis pathway, b) to study the role of defined lipoproteins, c) to identify lipoprotein transport mechanisms and d) to investigate genes involved in phagosome maturation arrest.