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Regulation of translation initiation in the yeast Saccharomyces cerevisia

English title Regulation of translation initiation in the yeast Saccharomyces cerevisia
Applicant Altmann Michael
Number 119996
Funding scheme Project funding (Div. I-III)
Research institution Institut für Biochemie und Molekulare Medizin Universität Bern
Institution of higher education University of Berne - BE
Main discipline Molecular Biology
Start/End 01.09.2008 - 30.04.2012
Approved amount 243'000.00
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All Disciplines (2)

Discipline
Molecular Biology
Biochemistry

Keywords (6)

Initiation of translation; eukaryotic initiation factors; cap-independent translation; yeast; filamentous; invasive growth

Lay Summary (English)

Lead
Lay summary
From our current knowledge we can conclude that the mechanism and the regulation of translation are very conserved among all eukaryotes. The yeast Saccharomyces cerevisiae provides a valuable system to study the fundamental steps of translation and its regulation in eukaryotes. Repressors of protein synthesis play a very important role in helping to regulate the metabolic activity of the cell under a variety of nutritional and developmental conditions. A structural and functional characterization of so far identified repressors under conditions when cap-independent translation allows for a developmental switch for invasive / filamentous growth and for mitotic division will help to understand this process.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

Employees

Publications

Publication
Unique modifications of translation elongation factors.
Greganova Eva, Altmann Michael, Bütikofer Peter (2011), Unique modifications of translation elongation factors., in The FEBS journal, 278(15), 2613-24.
Power of yeast for analysis of eukaryotic translation initiation.
Altmann Michael, Linder Patrick (2010), Power of yeast for analysis of eukaryotic translation initiation., in The Journal of biological chemistry, 285(42), 31907-12.
Origins and evolution of the mechanisms regulating translation initiation in eukaryotes.
Hernández Greco, Altmann Michael, Lasko Paul (2010), Origins and evolution of the mechanisms regulating translation initiation in eukaryotes., in Trends in biochemical sciences, 35(2), 63-73.
Selective pharmacological targeting of a DEAD box RNA helicase.
Lindqvist Lisa, Oberer Monika, Reibarkh Mikhail, Cencic Regina, Bordeleau Marie-Eve, Vogt Emily, Marintchev Assen, Tanaka Junichi, Fagotto Francois, Altmann Michael, Wagner Gerhard, Pelletier Jerry (2008), Selective pharmacological targeting of a DEAD box RNA helicase., in PloS one, 3(2), 1-11.
Crystal structure of the yeast eIF4A-eIF4G complex: an RNA-helicase controlled by protein-protein interactions.
Schütz Patrick, Bumann Mario, Oberholzer Anselm Erich, Bieniossek Christoph, Trachsel Hans, Altmann Michael, Baumann Ulrich (2008), Crystal structure of the yeast eIF4A-eIF4G complex: an RNA-helicase controlled by protein-protein interactions., in Proceedings of the National Academy of Sciences of the United States of America, 105(28), 9564-9.
Binding specificities and potential roles of isoforms of eukaryotic initiation factor 4E in Leishmania.
Yoffe Yael, Zuberek Joanna, Lerer Asaf, Lewdorowicz Magdalena, Stepinski Janusz, Altmann Michael, Darzynkiewicz Edward, Shapira Michal (2006), Binding specificities and potential roles of isoforms of eukaryotic initiation factor 4E in Leishmania., in Eukaryotic cell, 5(12), 1969-79.

Associated projects

Number Title Start Funding scheme
104207 Regulation of translation initiation in the yeast Saccharomyces cerevisiae 01.04.2004 Project funding (Div. I-III)
146722 Regulation of translation initiation in the yeast Saccharomyces cerevisiae 01.06.2013 Project funding (Div. I-III)

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