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Multi-nuclear magnetic resonance spectroscopy (MRS) and imaging (MRI) on a clinical whole-body MR-system: integration and application of the MR-toolbox for studies on insulin resistance

English title Multi-nuclear magnetic resonance spectroscopy (MRS) and imaging (MRI) on a clinical whole-body MR-system: integration and application of the MR-toolbox for studies on insulin resistance
Applicant Boesch Chris
Number 118219
Funding scheme Project funding
Research institution Abt. Magnetresonanz-Spektroskopie u. Method. Departement für Klinische Forschung Universität Bern
Institution of higher education University of Berne - BE
Main discipline Endocrinology
Start/End 01.12.2007 - 30.11.2010
Approved amount 296'000.00
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All Disciplines (6)

Discipline
Endocrinology
Biophysics
Clinical Nutritional Research
Clinical Endocrinology
Physiology : other topics
Nutritional Research, Vitaminology

Keywords (10)

magnetic resonance spectroscopy; magnetic resonance imaging; intramyocellular lipids; Magnetic resonance methodology; Diabetes; Insulin-resistance; Intrahepatic lipids; Lipid metabolism; Glycogen metabolism; Mitochondrial activity

Lay Summary (English)

Lead
Lay summary
Insulin resistance and the related risk factors became epidemic dimensions in the last two decades. Magnetic resonance imaging (MRI) and spectroscopy (MRS) are specifically suited to study the pathogenesis of this cluster of diseases. This grant proposal will contribute to this methodology and apply it to questions of causes and effects in this pathology.Insulin resistance is strongly related to energy intake and the ability to use this energy - a mismatch of these factors leads to an accumulation of high-energy metabolites and, subsequently, to an imbalance of the regulation. While modern life style is a major factor for this imbalance, it is not the only possible reason. E.g. slim offsprings of diabetes patients already show an increased probability for insulin-resistance.Knowing that mainly visceral fat is correlated with insulin resistance, MRI is very helpful since it can provide data on whole body fat distribution, i.e. on the ratio of subcutaneous fat vs. visceral fat, non-invasively and repeatedly. MRS reveals data on the major energy supply of the human body non-invasively, in particular intramyocellular lipids (IMCL), intra-hepatic lipids (IHCL), and on glycogen in skeletal muscle and liver. In addition to these energy stores, MRS reveals data on mitochondrial function and, therefore, on the ability of the body to make the energy reserves available for physical activity. While these MRI/MRS methods are known and applied, a lot needs to be done to combine within a reasonable time frame and to improve them, in particular in overweight patients.Changes of the whole body fat distribution, the major energy reserves, and the mitochondrial activity can be followed in diet and exercise studies as well as in the comparison of different patient groups. This shall allow evaluating the correlation between these measurements and the insulin-sensitivity. Subsequently, these studies shall help to distinguish between cause and effect, e.g. are high levels of intramyocellular lipids a cause or an effect of insulin-resistance? If it is a cause, an interventional reduction may help to improve insulin-sensitivity, if is an effect, a reduction would just silence a messenger without changing the disease. Since athletes also have high levels of these lipids, we hypothesize that the absolute level of these lipids is less relevant than the ability to reduce and replenish these stores. Similar questions are raised for the other energy reserves.The non-ionizing, safe and non-invasive measurement, the repeatability and the relatively high accuracy of MRI/MRS make these methods particularly suited for clinical studies.
Direct link to Lay Summary Last update: 21.02.2013

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105815 Multi-nuclear magnetic resonance spectroscopy (MRS) and imaging (MRI) on a clinical whole-body MR-system: non-invasive observation of metabolism in healthy and diabetic skeletal muscle and liver tissue 01.12.2004 Project funding
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