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Weight cycling during growth: A risk factor for cardiovascular and renal diseases

English title Weight cycling during growth: A risk factor for cardiovascular and renal diseases
Applicant Montani Jean-Pierre
Number 118041
Funding scheme Project funding
Research institution Division de Physiologie Département de Médecine Université de Fribourg
Institution of higher education University of Fribourg - FR
Main discipline Cardiovascular Research
Start/End 01.10.2007 - 30.09.2011
Approved amount 296'000.00
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Keywords (8)

hypertension; obesity; weight cycling; renal diseases; weight cycling; renal diseases; hypertension; obesity

Lay Summary (English)

Lead
Lay summary
The repetition of periods of diet-induced weight loss and periods of weight gain, a phenomenon known as weight cycling, is common in obese adults and adolescents.  Using young growing rats with cycled food intake on a normal chow (cycles of 3 days of food restriction followed by 3 days of food excess) followed by 2 weeks of high fat controlled refeeding, we analyzed body weight and body composition changes, as well as hormonal profile, key enzymes of the lipid metabolism and controllers of the oxidative balance.  The results show that the lipogenic machinery is maximally activated before refeeding.  In addition, stress hormones are activated and key regulators of the oxidative balance show that weight cycling may promote oxidative stress.  Altogether, our studies show that weight cycling show a detrimental metabolic profile, with fat accumulation and activation of stress and oxidative pathways.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

Employees

Publications

Publication
A role for pancreatic beta-cell secretory hyperresponsiveness in catch-up growth hyperinsulinemia: Relevance to thrifty catch-up fat phenotype and risks for type 2 diabetes.
Casimir Marina, de Andrade Paula B, Gjinovci Asllan, Montani Jean-Pierre, Maechler Pierre, Dulloo Abdul G (2011), A role for pancreatic beta-cell secretory hyperresponsiveness in catch-up growth hyperinsulinemia: Relevance to thrifty catch-up fat phenotype and risks for type 2 diabetes., in Nutrition & metabolism, 8(1), 2-2.
Dietary modulation of body composition and insulin sensitivity during catch-up growth in rats: effects of oils rich in n-6 or n-3 PUFA.
Yepuri Gayathri, Marcelino Helena, Shahkhalili Yasaman, Aprikian Olivier, Macé Katherine, Seydoux Josiane, L Miles Jennifer, Montani Jean-Pierre, Dulloo Abdul G (2011), Dietary modulation of body composition and insulin sensitivity during catch-up growth in rats: effects of oils rich in n-6 or n-3 PUFA., in The British journal of nutrition, 1-14.
Angiogenesis
Adair Thomas H., Montani Jean-Pierre (2010), Angiogenesis, Morgan & Claypool Life Sciences, San Rafael, California.
Angiogenic growth factor responses to long-term treadmill exercise in mice.
Pryor Janelle S, Montani Jean-Pierre, Adair Thomas H (2010), Angiogenic growth factor responses to long-term treadmill exercise in mice., in Indian journal of physiology and pharmacology, 54(4), 309-17.
Body composition phenotypes in pathways to obesity and the metabolic syndrome.
Dulloo A G, Jacquet J, Solinas G, Montani J-P, Schutz Y (2010), Body composition phenotypes in pathways to obesity and the metabolic syndrome., in International journal of obesity (2005), 34 Suppl 2, 4-17.
Phenotyping for early predictors of obesity and the metabolic syndrome.
Dulloo A G, Montani J-P (2010), Phenotyping for early predictors of obesity and the metabolic syndrome., in International journal of obesity (2005), 34 Suppl 2, 1-3.
Exposure to a high-fat diet alters leptin sensitivity and elevates renal sympathetic nerve activity and arterial pressure in rabbits.
Prior Larissa J, Eikelis Nina, Armitage James A, Davern Pamela J, Burke Sandra L, Montani Jean-Pierre, Barzel Benjamin, Head Geoffrey A (2010), Exposure to a high-fat diet alters leptin sensitivity and elevates renal sympathetic nerve activity and arterial pressure in rabbits., in Hypertension, 55(4), 862-8.
Role of mutation of the circadian clock gene Per2 in cardiovascular circadian rhythms.
Vukolic Ana, Antic Vladan, Van Vliet Bruce N, Yang Zhihong, Albrecht Urs, Montani Jean-Pierre (2010), Role of mutation of the circadian clock gene Per2 in cardiovascular circadian rhythms., in American journal of physiology. Regulatory, integrative and comparative physiology, 298(3), R627-R634.
Weight cycling during growth and beyond as a risk factor for later cardiovascular diseases: the 'repeated overshoot' theory.
Montani J-P, Viecelli A K, Prévot A, Dulloo A G (2006), Weight cycling during growth and beyond as a risk factor for later cardiovascular diseases: the 'repeated overshoot' theory., in International journal of obesity (2005), 30 Suppl 4, 58-66.

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
Body composition, Thermogenesis & Inflammation in Pathogenesis of Obesity and Metabolic Syndrome 23.09.2011 University of Fribourg
Phenotyping for Early Predictors of Obesity and Metabolic Syndrome 04.09.2009 University of fribourg


Associated projects

Number Title Start Funding scheme
102146 Obesity-Induced Hypertension and Weight Cycling: the Contributory Role of Progressive Vascular Dysfunction 01.10.2003 Project funding

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