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DNA-Like Architectures with Polyaromatic Hydrocarbons

English title DNA-Like Architectures with Polyaromatic Hydrocarbons
Applicant Häner Robert
Number 117617
Funding scheme Project funding (Div. I-III)
Research institution Departement für Chemie, Biochemie und Pharmazie Universität Bern
Institution of higher education University of Berne - BE
Main discipline Organic Chemistry
Start/End 01.10.2007 - 30.09.2010
Approved amount 459'993.00
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Keywords (7)

bioorganic chemistry; modified oligonucleotides; fluorescence; pistacking; DNA mimics; nanotechnology; pi-stacking

Lay Summary (English)

Lay summary
The construction of nucleic acid like structures with novel types of polyaromatic building blocks is pursued. Synthetic efforts will concentrate on the development of suitable pyrene derivatives for incoporation into oligodeoxynucleotides. Structural, spectroscopic and electronic properties of the obtained oligomers are investigated. DNA-like oligomers containing such types of building blocks give rise to hybrids with novel structural and functional properties. Hybridisation of the modified oligomers will result in the formation of duplex, triplex and quadruplex structures with biomimetic properties. Since the polyaromatic building blocks generally possess interesting spectroscopic properties, such as monomer or excimer fluorescence, the may also find application in the fields of diagnostics and material research.
Direct link to Lay Summary Last update: 21.02.2013

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Associated projects

Number Title Start Funding scheme
109482 Non-nucleosidic DNA building blocks 01.10.2005 Project funding (Div. I-III)
132581 DNA-assisted self-organization of aromatic chromophores 01.10.2010 Project funding (Div. I-III)
128724 Purchase of a single crystal X-ray diffractometer for high resolution and accurate studies on molecular crystals 01.12.2009 R'EQUIP