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Mechanistic investigations of organocatalytic and metal based reactions / React-IR

English title Mechanistic investigations of organocatalytic and metal based reactions / React-IR
Applicant Wennemers Helma
Number 117360
Funding scheme R'EQUIP
Research institution Departement Chemie Universität Basel
Institution of higher education University of Basel - BS
Main discipline Organic Chemistry
Start/End 01.07.2007 - 30.06.2008
Approved amount 103'877.00
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Keywords (9)

asymmetric catalysis; hydrogenations; organocatalysis; peptides; material science; chiral coordination compounds; dendrimers; chiral induction; Pfeiffer effect

Lay Summary (English)

Lay summary
ReactIR spectroscopy allows for on-line monitoring of reactions under the actual reaction conditions. In comparison to other analysis methods it does not require to disturb the reaction by e.g. sample removal. In situ IR reaction monitoring is therefore a particularly valuable tool for mechanistic studies and optimization of reaction conditions. We will use the instrument to gain insight into the mechanism of reactions that are catalyzed by metal-based catalysts or organocatalysts and to optimize the reaction conditions.
With respect to metal-based catalysts, asymmetric hydrogenations, Cu-catalyzed asymmetric acylation of alcohols, Cu- and Ag-catalyzed cycloadditions as well as Heck reactions will be examined (research of Prof. A. Pfaltz, supported by SNF grant 200020-107587). In the area of organocatalysts, we will study the mechanism of aldol and conjugate addition reactions that are catalyzed by peptidic catalysts (research of Prof. H. Wennemers, supported by SNF grant 200020-109511). Furthermore, the self-assembly of functional solid state materials based upon one-, two and three-dimensional coordination structures will be elucidated (research of Prof. E. Constable, supported by SNF grant 200020-113305/1).
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

Associated projects

Number Title Start Funding scheme
109511 Peptide: molekulare Erkennung, Organokatalyse und Spaltung 01.10.2005 Project funding
131872 Bioinspirierte Chemie mit Peptiden: Von Asymmetrischer Katalyse zu Nanopartikeln 01.10.2010 Project funding