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Familiäre Häufung des femoro-acetabulären Impingements: eine Pilotstudie

English title Familial aggregation of femoro-acetabular impingement: a pilot study
Applicant Jüni Peter
Number 117207
Funding scheme NRP 53 Musculoskeletal Health - Chronic Pain
Research institution Institut für Sozial- und Präventivmedizin Universität Bern
Institution of higher education University of Berne - BE
Main discipline Diseases of Bones and Joints
Start/End 01.08.2007 - 31.03.2009
Approved amount 131'241.00
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All Disciplines (2)

Discipline
Diseases of Bones and Joints
Respiratory Diseases

Keywords (2)

Osteoarthritis; Genteic epidemiology

Lay Summary (English)

Lead
Lay summary
Background
Osteoarthritis is one of the leading musculoskeletal causes of pain and disability. A decreased anterior offset i.e. a decreased difference between the anterior contour of the head and the femoral neck may result in repetitive damage of the peripheral articular cartilage of the hip joint during flexion and internal rotation, a phenomenon referred to as femoro-acetabular impingement. Cam type impingement, which is usually seen in men, is caused by the presence of a femoral neck protuberance with a non-spherical femoral head. Impingement can subsequently lead to osteoarthritis. Although several risk factors for femoro-acetabular impingement have been identified (e.g. fractures, surgery) most of the patients with femoro-acetabular impingement seen in orthopedic surgery lack a history of known predisposing factors. Previous studies suggest that femoral head and neck abnormalities develop during organogenesis.

Aim
To determine
• whether ‘cam’ type femoro-acetabular impingement clusters in families
• whether clustering is related to common risk factors or to genetic susceptibility
• how genetic susceptibility may be inherited


Significance
This project will help to understand the etiology of osteoarthritis. Patients with primary osteoarthritis are usually young with a considerable capacity to loose disability adjusted life-years. The identification of risk factors may help to develop additional treatment options including preventive interventions.
Direct link to Lay Summary Last update: 21.02.2013

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