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Cholinergic Mechanisms of Learning and Cognition

English title Cholinergic Mechanisms of Learning and Cognition
Applicant Rainer Gregor
Number 117106
Funding scheme EURYI (European Young Investigators)
Research institution Division de Physiologie Département de Médecine Université de Fribourg
Institution of higher education University of Fribourg - FR
Main discipline Neurophysiology and Brain Research
Start/End 01.04.2008 - 31.12.2016
Approved amount 1'947'411.00
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Keywords (4)

fMRI; cognitive; neuroscience; neuropharmacology

Lay Summary (English)

Lay summary
The overall aim of Rainer and his team’s proposed research is to localize and characterize effects of the cholinergic system on cognition and learning. They will study cholinergic effects in non-human primates, allowing the combination of a variety of state-of-the-art neurochemical, neurophysiological and biomedical imaging methods to study different aspects of cholinergic neuromodulation during precisely defined behavioral tasks. This will permit them to delineate acetylcholine-sensitive functional networks, revealing where, and by which mechanisms acetylcholine contributes to cognition and learning.Advances in the understanding of the processes that facilitate or degrade our cognitive abilities are likely to have a large impact on human welfare, allowing us to optimize conditions for learning, or counteract deficits associated with aging or neuropsychiatric disorders. In addition, the combination of these methods may prove ideal for assessing the potential of novel cholinergic pharmacological agents, speeding the process of drug discovery and testing.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants


Associated projects

Number Title Start Funding scheme
144998 Tracking visual information processing in humans and monkeys: from eye movements to neural coding 01.01.2013 R'EQUIP
143390 Impact of basal forebrain deep brain stimulation on information processing in the tree shrew visual cortex 01.10.2013 Project funding
182504 Basal forebrain modulatory circuit dissection 01.02.2019 Project funding
150801 High-density, multi-electrode array recordings in behaving monkeys - Fribourg application 01.10.2014 R'EQUIP
121308 High resolution mass spectrometry for in vivo characterization of bioactive compounds for brain and tumor research 01.10.2008 R'EQUIP
127179 Cholinergic Control of Attention in the Visual System 01.10.2009 ProDoc
141786 The Role of the Pulvinar in Visual Cognition 01.11.2012 ProDoc