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Islet inflammation in diabetes: from adaptation to failure

English title Islet inflammation in diabetes: from adaptation to failure
Applicant Donath Marc Yves
Number 116701
Funding scheme Project funding (Div. I-III)
Research institution Klinik für Endokrinologie, Diabetologie und Klinische Ernährung Universitätsspital Zürich
Institution of higher education University of Zurich - ZH
Main discipline Endocrinology
Start/End 01.04.2007 - 31.03.2010
Approved amount 377'000.00
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All Disciplines (2)

Discipline
Endocrinology
Pathophysiology

Keywords (4)

diabetes; pancreatic islet; IL-1 beta; IL-1Ra

Lay Summary (English)

Lead
Lay summary
Our research focuses on the mechanisms regulating beta-cell (the cell that produces insulin) adaptation to metabolic stress in type 2 diabetes. We have described a specific inflammatory process responsible for the failure of beta-cells in type 2 diabetes. In the present project, we hypothesise that islet inflammation is initially an attempt of the islet to adapt and repair itself in response to metabolic stress. If this initially physiological response is short-lived, it may be beneficial. If the response is sustained over a prolonged period of time at a high level of activity it will eventually become deleterious. Therefore, remodelling this response may promote survival and regeneration. Our overall goal is to characterize the putative physiological role of islet-derived cytokines and chemokines as well as of some immune cells in islet regeneration. It may open the door to therapeutic strategies aiming at remodeling this response. Several drugs enabling modulation of cytokines and chemokines are in clinical trials for the treatment of other diseases, e.g. rheumatic arthritis. Therefore, timely clinical evaluation is a realistic goal of this project.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

Employees

Associated projects

Number Title Start Funding scheme
68874 Mechanisms and modulation of glucose-induced Fas signaling in pancreatic beta-cells 01.03.2003 SNSF Professorships
130008 Islet inflammation in type 2 diabetes: pathogenesis and therapy 01.04.2010 Project funding (Div. I-III)
146840 Role of the innate immune system in the regulation of pancreatic islet function 01.04.2013 Project funding (Div. I-III)

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