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Memory T cell subsets in man and mouse: identification, characterization and function

English title Memory T cell subsets in man and mouse: identification, characterization and function
Applicant Sallusto Federica
Number 116440
Funding scheme Project funding
Research institution Istituto di ricerca in biomedicina (IRB) Facoltà di scienze biomedice
Institution of higher education Università della Svizzera italiana - USI
Main discipline Immunology, Immunopathology
Start/End 01.07.2007 - 30.06.2010
Approved amount 582'400.00
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Keywords (6)

human; mouse; immunology memory; T lymphocyte; Th1; Th2

Lay Summary (English)

Lead
Lay summary
The general aim of our project is to study effector and memory T lymphocytes, cells of the immune system that are generated in response to infectious pathogens and vaccination but that can also be generated in response to “self” structures, called autoantigens. These cells play an important role in protection but can also cause autoimmunity. We want to study the heterogeneity of effector and memory T cells, their functions, their role in the immune response and their differentiation from precursors, the so called naïve T cells. In the next three years we will focus on several open questions which will be addressed primarily in the human system and, when necessary, in experimental small animal models. These studies are expected to increase our understanding of effector and memory T cells in normal and pathological conditions and to provide relevant information for designing effective vaccines capable to elicit appropriate specific immune responses.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

Employees

Associated projects

Number Title Start Funding scheme
101962 Dissection of human memory T lymphocytes 01.10.2003 Project funding
131092 Effector and memory T cell subsets in man and mouse 01.07.2010 Project funding

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