Project

Back to overview

Rational design of organo-ruthenium anticancer compounds with novel modes of action

English title Rational design of organo-ruthenium anticancer compounds with novel modes of action
Applicant Dyson Paul
Number 116374
Funding scheme Project funding
Research institution Laboratoire de chimie organométallique et médicinale EPFL - SB - ISIC - LCOM
Institution of higher education EPF Lausanne - EPFL
Main discipline Inorganic Chemistry
Start/End 01.04.2007 - 31.03.2009
Approved amount 199'026.00
Show all

Keywords (8)

Bioorganometallic; Metal pharmaceuticals; Metal-DNA interactions; Metal-protein interactions; Molecular modelling; high resolution mass spectrometry; Metal-RNA interactions; Proteomics

Lay Summary (English)

Lead
Lay summary
In this project we are developing a new type of anticancer drug that show selective toxicity in secondary cancers (metastasis). Effective drugs for these secondary cancers are not available and with surgical removal of primary cancers being well developed it is these secondary cancers are largely responsible for death in cancer patients. Based on previous research we have discovered some compounds that are highly active on secondary cancers although at high doses. It is therefore necessary to modify their structure so that they are as effective at lower doses. In order to achieve this goal we must understand in detail how these drugs work, for example, how they reach the secondary cancer sites, what they do inside the cancer to destroy it, and why they are non-toxic to healthy tissue. In this project we try to answer these questions and at the same time, we intend to modify the drugs in a rational way to improve their activity. The successful outcome of this project will be having a greater understand of the mode of action of these drugs. In addition, we hope to develop a drug that is superior to those in current use and will enter clinical trials.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

Employees

Associated projects

Number Title Start Funding scheme
125173 Rational design of organo-ruthenium anticancer compounds with novel modes of action 01.04.2009 Project funding
107941 Rational design of organo-ruthenium anticancer compounds with novel modes of action 01.04.2005 Project funding
121262 R'Equip - Amélioration de deux spectromètres RMN 9.4T par des consôles digitales 01.07.2008 R'EQUIP
125173 Rational design of organo-ruthenium anticancer compounds with novel modes of action 01.04.2009 Project funding

-