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Sleep and brain plasticity during development

English title Sleep and brain plasticity during development
Applicant Huber Reto
Number 114923
Funding scheme SNSF Professorships
Research institution Interdisziplinäres Zentrum für Schlafmedizin Universitäts-Kinderkliniken
Institution of higher education University of Zurich - ZH
Main discipline Neurophysiology and Brain Research
Start/End 01.07.2007 - 30.06.2011
Approved amount 1'268'425.00
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Keywords (8)

sleep regulation; plasticity; brain development; synaptic homeostasis; children; adolescence; human brain; plastic processes

Lay Summary (English)

Lead
Lay summary
Children spend half of their lives asleep (Iglowstein et al., 2003). This increased sleep need is accompanied by extensive learning processes during the day. Because of the intertwined relationship between sleep and wakefulness (Borbély, 1982; Jenni and LeBourgeois, 2006) the question arises whether sleep and learning share common mechanisms in developmental processes of the brain. This question is of particular clinical interest because a large percentage of children suffer from sleep disorders (~ 20-30%; (Mindell et al., 1999) and/or learning disabilities (e.g. up to 10% of the children require special schooling in Switzerland; (Walther-Müller and Häfeli, 2005). Is there a direct link between sleep disorders and learning disabilities? To address this question the relationship between sleep and learning in children and adolescents needs to be examined. We propose to address this question by using a combination of high-density electroencephalographic (hd-EEG) recordings, and visuomotor learning tasks in children and adolescents.


Kinder verbringen die Hälfte ihres Lebens schlafend (Iglowstein et al., 2003). Dieses grosse Schlafbedürfnis geht einher mit intensiven Lernvorgängen während dem Tag. Wegen der verflochtenen Beziehung von Schlaf und Wach (Borbély, 1982; Jenni and LeBourgeois, 2006) stellt sich die Frage, ob während der Hirnentwicklung Schlaf und Lernen gemeinsame Mechanismen teilen. Die Frage ist von grossem klinischem Interesse da ein grosser Prozentsatz von Kindern unter Schlafstörungen leidet (~ 20-30%; Mindell et al., 1999) und/oder Lernbehinderungen haben (zum Beispiel bis zu 10% der Schweizer Kinder benötigen Sonderschulung; Walther-Müller and Häfeli, 2005). Gibt es also einen direkten Zusammenhang zwischen Schlafstörungen und Lernbehinderung? Um dieser Frage nachzugehen muss die Beziehung zwischen Schlaf und Lernen in Kindern und Jugendlichen untersucht werden. In meinem Projekt schlage ich vor dieser Frage mit einer Kombination von hochauflösender Hirnstrommessung während dem Schlaf und visuomotorischen Lerntests nachzugehen.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

Employees

Publications

Publication
Chronic social stress leads to altered sleep homeostasis in mice
Olini Nadja, Rothfuchs Iru, Azzinnari Damiano, Pryce Christopher R., Kurth Salome, Huber Reto (2017), Chronic social stress leads to altered sleep homeostasis in mice, in Behavioural Brain Research, 327, 167-173.
Developmental trajectories of EEG sleep slow wave activity as a marker for motor skill development during adolescence: a pilot study.
Lustenberger Caroline, Mouthon Anne-Laure, Tesler Noemi, Kurth Salome, Ringli Maya, Buchmann Andreas, Jenni Oskar G, Huber Reto (2016), Developmental trajectories of EEG sleep slow wave activity as a marker for motor skill development during adolescence: a pilot study., in Developmental psychobiology.
Increased frontal sleep slow wave activity in adolescents with major depression.
Tesler Noemi, Gerstenberg Miriam, Franscini Maurizia, Jenni Oskar G, Walitza Susanne, Huber Reto (2015), Increased frontal sleep slow wave activity in adolescents with major depression., in NeuroImage. Clinical, 10, 250-6.
Reduced sleep spindle density in early onset schizophrenia: a preliminary finding.
Tesler Noemi, Gerstenberg Miriam, Franscini Maurizia, Jenni Oskar G, Walitza Susanne, Huber Reto (2015), Reduced sleep spindle density in early onset schizophrenia: a preliminary finding., in Schizophrenia research, 166(1-3), 355-7.
Diurnal changes in electrocorticogram sleep slow-wave activity during development in rats.
Olini Nadja, Huber Reto (2014), Diurnal changes in electrocorticogram sleep slow-wave activity during development in rats., in Journal of sleep research, 23(3), 261-7.
Overnight changes in the slope of sleep slow waves during infancy.
Fattinger Sara, Jenni Oskar G, Schmitt Bernhard, Achermann Peter, Huber Reto (2014), Overnight changes in the slope of sleep slow waves during infancy., in Sleep, 37(2), 245-53.
Sleep slow-wave activity reveals developmental changes in experience-dependent plasticity.
Wilhelm Ines, Kurth Salomé, Ringli Maya, Mouthon Anne-Laure, Buchmann Andreas, Geiger Anja, Jenni Oskar G, Huber Reto (2014), Sleep slow-wave activity reveals developmental changes in experience-dependent plasticity., in The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(37), 12568-75.
Spike wave location and density disturb sleep slow waves in patients with CSWS (continuous spike waves during sleep).
Bölsterli Heinzle Bigna K, Fattinger Sara, Kurth Salomé, Lebourgeois Monique K, Ringli Maya, Bast Thomas, Critelli Hanne, Schmitt Bernhard, Huber Reto (2014), Spike wave location and density disturb sleep slow waves in patients with CSWS (continuous spike waves during sleep)., in Epilepsia, 55(4), 584-91.
Developmental changes in sleep and their relationships to psychiatric illnesses.
Tesler Noemi, Gerstenberg Miriam, Huber Reto (2013), Developmental changes in sleep and their relationships to psychiatric illnesses., in Current opinion in psychiatry, 26(6), 572-9.
Stimulation of the brain with radiofrequency electromagnetic field pulses affects sleep-dependent performance improvement.
Lustenberger Caroline, Murbach Manuel, Dürr Roland, Schmid Marc Ralph, Kuster Niels, Achermann Peter, Huber Reto (2013), Stimulation of the brain with radiofrequency electromagnetic field pulses affects sleep-dependent performance improvement., in Brain stimulation, 6(5), 805-11.
The effects of caffeine on sleep and maturational markers in the rat.
Olini Nadja, Kurth Salomé, Huber Reto (2013), The effects of caffeine on sleep and maturational markers in the rat., in PloS one, 8(9), 72539-72539.
Topography of sleep slow wave activity in children with attention-deficit/hyperactivity disorder.
Ringli Maya, Souissi Soraya, Kurth Salomé, Brandeis Daniel, Jenni Oskar G, Huber Reto (2013), Topography of sleep slow wave activity in children with attention-deficit/hyperactivity disorder., in Cortex; a journal devoted to the study of the nervous system and behavior, 49(1), 340-7.
High density electroencephalography in sleep research: potential, problems, future perspective.
Lustenberger Caroline, Huber Reto (2012), High density electroencephalography in sleep research: potential, problems, future perspective., in Frontiers in neurology, 3, 77-77.
Mapping the electrophysiological marker of sleep depth reveals skill maturation in children and adolescents.
Kurth Salome, Ringli Maya, Lebourgeois Monique K, Geiger Anja, Buchmann Andreas, Jenni Oskar G, Huber Reto (2012), Mapping the electrophysiological marker of sleep depth reveals skill maturation in children and adolescents., in NeuroImage, 63(2), 959-65.
The sleep EEG as a marker of intellectual ability in school age children.
Geiger Anja, Huber Reto, Kurth Salomé, Ringli Maya, Jenni Oskar G, Achermann Peter (2012), The sleep EEG as a marker of intellectual ability in school age children., in Sleep, 34(2), 181-9.
Triangular relationship between sleep spindle activity, general cognitive ability and the efficiency of declarative learning.
Lustenberger Caroline, Maric Angelina, Dürr Roland, Achermann Peter, Huber Reto (2012), Triangular relationship between sleep spindle activity, general cognitive ability and the efficiency of declarative learning., in PloS one, 7(11), 49561-49561.
Anatomical markers of sleep slow wave activity derived from structural magnetic resonance images.
Buchmann Andreas, Kurth Salomé, Ringli Maya, Geiger Anja, Jenni Oskar G, Huber Reto (2011), Anatomical markers of sleep slow wave activity derived from structural magnetic resonance images., in Journal of sleep research, 20(4), 506-13.
Developmental aspects of sleep slow waves: linking sleep, brain maturation and behavior.
Ringli Maya, Huber Reto (2011), Developmental aspects of sleep slow waves: linking sleep, brain maturation and behavior., in Progress in brain research, 193, 63-82.
EEG sleep slow-wave activity as a mirror of cortical maturation.
Buchmann Andreas, Ringli Maya, Kurth Salomé, Schaerer Margot, Geiger Anja, Jenni Oskar G, Huber Reto (2011), EEG sleep slow-wave activity as a mirror of cortical maturation., in Cerebral cortex (New York, N.Y. : 1991), 21(3), 607-15.
Impaired slow wave sleep downscaling in encephalopathy with status epilepticus during sleep (ESES).
Bölsterli Bigna K, Schmitt Bernhard, Bast Thomas, Critelli Hanne, Heinzle Jakob, Jenni Oskar G, Huber Reto (2011), Impaired slow wave sleep downscaling in encephalopathy with status epilepticus during sleep (ESES)., in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiol, 122(9), 1779-87.
Characteristics of sleep slow waves in children and adolescents.
Kurth Salomé, Jenni Oskar G, Riedner Brady A, Tononi Giulio, Carskadon Mary A, Huber Reto (2010), Characteristics of sleep slow waves in children and adolescents., in Sleep, 33(4), 475-80.
Mapping of cortical activity in the first two decades of life: a high-density sleep electroencephalogram study.
Kurth Salomé, Ringli Maya, Geiger Anja, LeBourgeois Monique, Jenni Oskar G, Huber Reto (2010), Mapping of cortical activity in the first two decades of life: a high-density sleep electroencephalogram study., in The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(40), 13211-9.

Knowledge transfer events

Active participation

Title Type of contribution Date Place Persons involved
Brainfair Performances, exhibitions (e.g. for education institutions) 16.03.2013 Zurich, Switzerland Olini Nadja; Huber Reto; Kurth Salomé; Ringli Maya; Tesler Noemi Agneta; Mouthon Anne-Laure;
Scientifica Performances, exhibitions (e.g. for education institutions) 26.08.2011 Zurich, Switzerland Olini Nadja; Kurth Salomé; Ringli Maya; Huber Reto;


Associated projects

Number Title Start Funding scheme
179443 Manipulating cortical synchronization by means of closed-loop acoustic stimulation during sleep - method optimization and proof of concept study in childhood epilepsy 01.03.2019 Project funding (Div. I-III)
135438 Mapping sensitive periods of cortical development 01.07.2011 SNSF Professorships

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