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Molecular mechanisms of nutrient acquisition in parasites

English title Molecular mechanisms of nutrient acquisition in parasites
Applicant Mäser Pascal
Number 114819
Funding scheme SNSF Professorships
Research institution Swiss Tropical and Public Health Institute
Institution of higher education University of Basel - BS
Main discipline Experimental Microbiology
Start/End 01.05.2007 - 30.09.2009
Approved amount 589'058.00
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All Disciplines (2)

Discipline
Experimental Microbiology
Molecular Biology

Keywords (11)

MOLECULAR PARASITOLOGY; chemotherapy; transporters; adenosine; potassium; functional genomics; Comparative genomics; Adenosine transporter; Potassium channel; Drug resistance; Trypanosoma brucei

Lay Summary (English)

Lead
Lay summary
All parasites acquire nutrients from their hosts - that's the very essence of parasitism. Elucidation of the molecular mechanisms underlying import and metabolism of nutrients will help to understand how parasites have adapted to living within a host. It will also disclose drug targets for specific chemotherapy because nutrient acquisition is essential for parasite survival. Furthermore, nutrient uptake pathways may be exploited for drug targeting, delivering toxic compounds to parasites via conduits that are absent in host cells. Here I propose to combine experimental and computational approaches to (i) dissect adenosine salvage pathways in Trypanosoma brucei and exploit them for drug targeting; (ii) elucidate the molecular mechanisms of K+ homeostasis in T. brucei; (iii) perform genome-wide comparisons between parasites and their hosts based on predicted transportomes. The anticipated results will reveal divergent and convergent metabolic strategies of parasites, deepening our understanding of how they adapted for life within a host. They will also indicate new possibilities for specific antiparasitic chemotherapy, for drug targets as well as for drug targeting.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

Employees

Associated projects

Number Title Start Funding scheme
66150 Molecular mechanisms of nutrient transport and drug resistance in Trypanosoma brucei 01.05.2003 SNSF Professorships
135746 Drug resistance in African trypanosomes - a deep sequencing approach 01.07.2011 Project funding (Div. I-III)
127300 Functional genomics of nutrient transporters in Trypanosoma brucei: From physiology to pharmacology 01.01.2010 Sinergia
127300 Functional genomics of nutrient transporters in Trypanosoma brucei: From physiology to pharmacology 01.01.2010 Sinergia

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