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Genetic and functional characterization of a family of membrane proteins modulating methicillin resistance and cell envelope composition in Staphylococcus aureus

English title Genetic and functional characterization of a family of membrane proteins modulating methicillin resistance and cell envelope composition in Staphylococcus aureus
Applicant Stutzmann Meier Patricia
Number 114323
Funding scheme Marie Heim-Voegtlin grants
Research institution Institut für Medizinische Mikrobiologie Universität Zürich
Institution of higher education University of Zurich - ZH
Main discipline Medical Microbiology
Start/End 01.10.2006 - 30.09.2008
Approved amount 233'568.00
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Keywords (5)

Staphylococcus aureus; membrane proteins; methicillin resistence; cell envelope; virulence

Lay Summary (English)

Lead
Lay summary
Staphylococcus aureus is an important pathogen with a high virulence potential and which has acquired resistance to most commonly used antibiotics. Three members of the poorly characterized family of LytR-CpsA-Psr cell-envelope attenuators have been detected in S. aureus.One member, MsrR, was shown to act as a repressor of sarA transcription, a global staphylococcal regulator, and to modulate beta-lactam susceptibility. We hypothesize that this protein family is involved in sensing and modulating the composition of the cell envelope. We propose a thorough genetic and functional analysis of the third, yet uncharacterized, member of this family, SA2103, with regard to its role in antibiotic resistance, influence on global regulators, adhesion and biofilm formation, and composition of the staphylococcal cell envelope. In addition, we propose to search for interacting members of a putative cell envelope regulatory network able to sense and modulate modifications of the cell surface according to the needs of S. aureus to survive and propagate.
Direct link to Lay Summary Last update: 21.02.2013

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