Project

Back to overview

A peripheral dose calculation model for estimating second cancer risk after breast radiotherapy

English title A peripheral dose calculation model for estimating second cancer risk after breast radiotherapy
Applicant Moeckli Raphaël
Number 114101
Funding scheme Project funding (Div. I-III)
Research institution Institut de Radiophysique Département de Radiologie Université de Lausanne/CHUV
Institution of higher education University of Lausanne - LA
Main discipline Experimental Cancer Research
Start/End 01.07.2007 - 30.06.2009
Approved amount 104'263.00
Show all

All Disciplines (2)

Discipline
Experimental Cancer Research
Clinical Cancer Research

Keywords (6)

radiation dosimetry; radiation protection; second cancer; peripheral dose; dose modelisation; radiation oncology

Lay Summary (English)

Lead
Lay summary
With increasing survival time of patients after cancer treatment, the risk of second cancers is becoming an important clinical issue in evaluating the risk/benefit balance of different treatments, especially radiotherapy. With the introduction of new techniques like intensity modulated radiotherapy or tomotherapy, the risk may be even higher because of increased beam-on times. Second cancer risk following radiotherapy is directly related to peripheral dose, i.e. the dose outside the irradiation fields. Most second cancers occur around the periphery of the irradiated volume.Peripheral dosimetry is necessary for epidemiological studies which seek to quantify the dose-response relationship and estimate the incidence of second cancers. Breast cancer is of particular relevance because it is the most common cancer among women (one in ten women will develop breast cancer in her lifetime), and because it represents a sizeable population of long-term survivors for second cancer studies.It is proposed to develop a Monte Carlo-based method for estimating peripheral dose. It consists in developing a matrix-based model using MC calculated peripheral doses, taking into account different parameters related to treatment units, treatment techniques, and patient morphology. The method will be validated by comparison with TLD measurements in anthropomorphic phantoms and patient-specific peripheral dose calculations for a sample of one hundred patients.The method will be applied retrospectively to calculate peripheral dose for the “RVT & CHUV Breast Cancer Cohort” of 1549 patients treated using radiotherapy. Within this cohort, a study will be performed in order to investigate and validate the relationship between the dose delivered at a given anatomical site and the absolute and relative risk of a second cancer. Finally, the same MC simulation method will be used in a prospective study to optimise treatment plans for minimum second cancer risk.The overall objective of this study is to develop, validate and apply a novel simulation-based method to estimate peripheral doses for patients treated with radiotherapy for breast cancer. It will enable peripheral doses to be calculated retrospectively for large numbers of patients for use in epidemiological studies on second cancer after breast radiotherapy. Epidemiological data from second cancers in radiotherapy are also important for radiation protection in order to better quantify the effects of low doses. Finally, the treatment planning optimisation tool will enable clinicians to consider second cancer risk when selecting a radiotherapy technique.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

Employees

Publications

Publication
A critical evaluation of secondary cancer risk models applied to Monte Carlo dose distributions of 2-dimensional, 3-dimensional conformal and hybrid intensity-modulated radiation therapy for breast cancer.
Joosten A, Bochud F, Moeckli R (2014), A critical evaluation of secondary cancer risk models applied to Monte Carlo dose distributions of 2-dimensional, 3-dimensional conformal and hybrid intensity-modulated radiation therapy for breast cancer., in Physics in medicine and biology, 59(16), 4697-722.
Evaluation of organ-specific peripheral doses after 2-dimensional, 3-dimensional and hybrid intensity modulated radiation therapy for breast cancer based on Monte Carlo and convolution/superposition algorithms: Implications for secondary cancer risk assessment.
Joosten Andreas, Matzinger Oscar, Jeanneret-Sozzi Wendy, Bochud François, Moeckli Raphaël (2013), Evaluation of organ-specific peripheral doses after 2-dimensional, 3-dimensional and hybrid intensity modulated radiation therapy for breast cancer based on Monte Carlo and convolution/superposition algorithms: Implications for secondary cancer risk assessment., in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 106(1), 33-41.
Variability of a peripheral dose among various linac geometries for second cancer risk assessment
Joosten A, Bochud F, Baechler S, Levi F, Mirimanoff RO, Moeckli R (2011), Variability of a peripheral dose among various linac geometries for second cancer risk assessment, in PHYSICS IN MEDICINE AND BIOLOGY, 56(16), 5131-5151.
PERIPHERAL ORGAN DOSES BY MONTE CARLO FOR CONVENTIONAL BREAST CANCER TREATMENT
Joosten A, Levi F, Baechler S, Mirimanoff RO, Bochud F, Moeckli R (2010), PERIPHERAL ORGAN DOSES BY MONTE CARLO FOR CONVENTIONAL BREAST CANCER TREATMENT, in STRAHLENTHERAPIE UND ONKOLOGIE, 186(12), 727-728.
PERIPHERAL DOSIMETRY BY MONTE CARLO FOR 6MV AND CO-60 BEAMS
Joosten A, Levi F, Baechler S, Mirimanoff RO, Bochud F, Moeckli R (2009), PERIPHERAL DOSIMETRY BY MONTE CARLO FOR 6MV AND CO-60 BEAMS, in STRAHLENTHERAPIE UND ONKOLOGIE, 185(9), 636-636.

Associated projects

Number Title Start Funding scheme
136785 Le suivi de jeunes patients d'oncologie par des examens de radiodiagnostic: une évaluation du risque radiologique en vue d'une optimisation des partiques 01.06.2012 DORE project funding

-