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Role of neuroprotective factors and specific mutations in murine experimental autoimmune encephalitis (EAE)

English title Role of neuroprotective factors and specific mutations in murine experimental autoimmune encephalitis (EAE)
Applicant Lalive Patrice
Number 113653
Funding scheme Project funding
Research institution Département de Pathologie et Immunologie Faculté de Médecine / CMU Université de Genève
Institution of higher education University of Geneva - GE
Main discipline Immunology, Immunopathology
Start/End 01.10.2006 - 30.09.2009
Approved amount 227'000.00
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Keywords (6)

autoimmune disease; multiple sclerosis (MS); Experimental autoimmune encephalomyelitis (EAE); central nervous system (CNS); remyelination; neuroprotection

Lay Summary (English)

Lead
Lay summary
The experiments proposed in this project should first elucidate whether HGF/SF, a factor newly investigated in inflammatory demyelinating diseases of the CNS, can induce myelinoprotection and neuroprotection in EAE. This question is of great importance since we know that neuro/myelino-protection is a crucial issue for patients affected by demyelinating diseases like MS. Our recent report showed that IFN-beta, an efficient drug that prevent relapses in MS, can induce HGF/SF secretion in inflammatory cells. Beside its role on OPC migration and differentiation, HGF/SF has a strong neuroprotective function as well as some anti-inflammatory properties in vitro and in vivo. These experiments could lead to new therapeutic strategies targeting the enhancement of remyelination/neuroprotection in MS through both direct and indirect increase of HGF/SF in the CNS.

Secondly, we plan to extend our investigation on specific gene mutations in vivo (PAI-1-/-). The results of these experiments may also contribute to a better understanding of MS pathogenesis and could thereby lead to specific therapies.

Finally, the project conducted in different mice lines represents a great opportunity to further test biomarkers of MS like anti-native MOG antibodies. Validation of these Abs as biomarkers and understanding of their function could be beneficial for both clinical follow up and therapeutic approach of MS patients.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

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Associated projects

Number Title Start Funding scheme
132705 Investigation of immunomodulatory effects of HGF in CNS autoimmunity 01.10.2010 Project funding

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