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Emotion and cognitive control in depression and anxiety

English title Emotion and cognitive control in depression and anxiety
Applicant Herwig Uwe
Number 112631
Funding scheme Project funding
Research institution Gerontopsychiatrisches Zentrum Psychiatrische Universitätsklinik Zürich
Institution of higher education University of Zurich - ZH
Main discipline Neurology, Psychiatry
Start/End 01.07.2006 - 30.09.2008
Approved amount 154'772.00
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Keywords (6)

Emotionen; kognitive Kontrolle; Depression; Angst; fMRT; TMS

Lay Summary (English)

Lead
Lay summary
Aims: Investigation of
-brain circuits involved in the processing of emotional information inpatients with major depression and anxiety
-the neural correlates of cognitive control as a psychotherapeuticintervention
-the influence of noradrenergic and serotonergic antidepressants onemotion processing brain regions
Strategically, neurobiological markers and more specific treatment strategies with response prediction on the pharmacological and psychotherapeutic level shall be proposed.
Context: Depression is one of the world’s leading causes for morbidity and disability. Anxiety is of high concomitance with depression, and anxiety disorders are of high prevalence. Investigating causes of depression and anxiety for developing more specific treatments is of high human and economic impact. Revealing disordered emotion processing circuits in depression and anxiety may provide a significant contribution towards elucidating their pathophysiology. An important cognitive function being concerned in depression and anxiety is expectation. According to the cognitive model of depression, patients have a negative expectation of future events. Anxiety itself can be seen as the expectation of an unknown future to be unpleasant. Another central aspect in emotion processing and emotion regulation is the cognitive control of emotions. On the neurobiological level, cognitive control may be accounted to prefrontal activity inhibiting relevant subcortical emotion processing regions.
Cognitive control is suggested to be dysfunctional in depression and anxiety. However, the underlying neurobiology of both, expectation and cognitive control, is not yet understood and should be further evaluated in order to establish biological markers for depression and anxiety. The results will further contribute to a pathophysiological concept of depression and anxiety on the systems neuroscience level..
Methods: A task for identifying brain areas involved in the expectation of unknown, unpleasant, pleasant, and neutral events will be applied. In healthy subjects, this task has been performed in pilot studies by using functional magnetic resonance imaging (fMRI) in a native version and by applying cognitive control. Both, the native task and the cognitive control version will be investigated in depressed and in anxiety patients.
The characteristics of cognitive control in depression and anxiety will be revealed in group comparing analyses. Further, the native task will be investigated under selective serotonergic and noradrenergic pharmacological challenge. Additionally, chronometric aspects of cortical emotion processing will be investigated by using transcranial magnetic stimulation (TMS).


Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

Employees

Publications

Publication
Chronometric features of processing unpleasant stimuli: a functional MRI-based transcranial magnetic stimulation study.
Kaffenberger Tina, Baumgartner Thomas, Koeneke Susan, Jäncke Lutz, Herwig Uwe (2008), Chronometric features of processing unpleasant stimuli: a functional MRI-based transcranial magnetic stimulation study., in Neuroreport, 19(7), 777-81.
Anticipation of aversive stimuli activates extended amygdala in unipolar depression.
Abler Birgit, Erk Susanne, Herwig Uwe, Walter Henrik (2007), Anticipation of aversive stimuli activates extended amygdala in unipolar depression., in Journal of psychiatric research, 41(6), 511-22.
Modulation of anticipatory emotion and perception processing by cognitive control.
Herwig Uwe, Baumgartner Thomas, Kaffenberger Tina, Brühl Annette, Kottlow Mara, Schreiter-Gasser Ursula, Abler Birgit, Jäncke Lutz, Rufer Michael (2007), Modulation of anticipatory emotion and perception processing by cognitive control., in NeuroImage, 37(2), 652-62.
The involvement of primary motor cortex in mental rotation revealed by transcranial magnetic stimulation.
Eisenegger C, Herwig U, Jäncke L (2007), The involvement of primary motor cortex in mental rotation revealed by transcranial magnetic stimulation., in The European journal of neuroscience, 25(4), 1240-4.
Expecting unpleasant stimuli--an fMRI study.
Herwig Uwe, Abler Birgit, Walter Henrik, Erk Susanne (2007), Expecting unpleasant stimuli--an fMRI study., in Psychiatry research, 154(1), 1-12.
Neural correlates of a 'pessimistic' attitude when anticipating events of unknown emotional valence.
Herwig Uwe, Kaffenberger Tina, Baumgartner Thomas, Jäncke Lutz (2007), Neural correlates of a 'pessimistic' attitude when anticipating events of unknown emotional valence., in NeuroImage, 34(2), 848-58.
Extensive training of elementary finger tapping movements changes the pattern of motor cortex excitability.
Koeneke S, Lutz K, Herwig U, Ziemann U, Jäncke L (2006), Extensive training of elementary finger tapping movements changes the pattern of motor cortex excitability., in Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale, 174(2), 199-209.

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
Annual Conference of the Swiss Society of Biological Psychiatry (SSBP) 25.03.2009 Bern, Schweiz
Deutsche Gesellschaft für Psychiatrie, Psychotherapie und Nervenheilkunde 2008 26.11.2008 Berlin, Deutschland
63rd Annual Meeting of the Society of Biological Psychiatry 2008 01.05.2008 Washington D.C., USA
62nd Annual Meeting of the Society of Biological Psychiatry 2007 17.05.2007 San Diego, USA


Associated projects

Number Title Start Funding scheme
120518 Emotionsregulation und Selbst-Repräsentation bei affektiven Störungen 01.10.2008 Project funding

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