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Host genetic and genomic determinants of susceptibility to HIV-1

English title Host genetic and genomic determinants of susceptibility to HIV-1
Applicant Telenti Amalio
Number 110012
Funding scheme Project funding (Div. I-III)
Research institution Institut de Microbiologie Faculté de Biologie et Médecine CHUV/Université de Lausanne
Institution of higher education University of Lausanne - LA
Main discipline Infectious Diseases
Start/End 01.11.2005 - 31.10.2010
Approved amount 837'000.00
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All Disciplines (2)

Discipline
Infectious Diseases
Genetics

Keywords (5)

HIV; evolution; genome studies; retroviruses; AIDS

Lay Summary (English)

Lead
Lay summary
There are differences in the susceptibility of humans to HIV-1. This genetic variability can be analysed by using a range of approaches - analysis of candidate genes, genome scans and genome-wide association analysis, and by analysis of signatures of selective pressure exerted by retroviruses and retroelements on the primate genome.This proposal implements a number of tools and develops dedicated biological systems to address these questions:1.Development of a standardized in vitro system where immortalized B lymphocytes from multigeneration families are transduced by HIV-based lentiviruses. The family structure allows genome scans to map loci associated with cellular susceptibility to HIV-1.2.Genome-wide association analyses on infected individuals. For this, DNA is genotype using Illumina technology: >500.000 SNPs per individual.3.Analysis of evolutionary pressures on genes involved in HIV pathogenesis. This approach allows also the reconstruction of ancestral proteins, thus assessing the steps leading to modern protein specificities.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

Employees

Associated projects

Number Title Start Funding scheme
148522 Swiss HIV Cohort Study (SHCS) 01.01.2014 Cohort Studies Large
134277 Swiss HIV Cohort Study (SHCS) 01.01.2011 Cohort Studies Large
130699 24 hours in the life of HIV-1 01.04.2010 Project funding (Div. I-III)
124943 Pharmacocinétique de population, pharmacogénétique, et profils métaboliques de la thérapie anti-HIV 01.04.2009 Project funding (special)
102293 Development of an in vitro model for population genetics of host factors influencing HIV-1 disease 01.11.2003 Project funding (special)
132863 Host evolutionary genomics of HIV-1 and other retroviruses 01.11.2010 Project funding (Div. I-III)

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