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GLAASS: The Geneva-Lausanne anosognosia in in acute stroke study: Looking for the mechanisms of self-awareness through focal brain lesions

English title GLAASS: The Geneva-Lausanne anosognosia in in acute stroke study: Looking for the mechanisms of self-awareness through focal brain lesions
Applicant Vuilleumier Patrik
Number 108367
Funding scheme Project funding
Research institution Service de Neurologie Département des Neurosciences Cliniques CHUV
Institution of higher education University of Lausanne - LA
Main discipline Neurology, Psychiatry
Start/End 01.05.2005 - 30.04.2007
Approved amount 223'334.00
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Keywords (3)

acute stroke; neurobehavioral changes; anosognosia

Lay Summary (English)

Lead
Lay summary
Our study investigates the incidence, clinical presentation, and neurobehavioral correlates of anosognosia - a striking disorder in some patients with brain lesions who remain unaware of, and even deny, their neurological deficits, such as paralysis (hemiplegia). Anosognosia is still poorly understood, and has only rarely been investigated in a systematic manner. We recruit a large sample of stroke patients from the hyperacute illness stage up to 6 months, through a prospective collaborative program in two neurology centers with acute stroke clinic in Geneva and Lausanne hospitals. We assess all patients with hemiplegia using a systematic battery of neurological and neuropsychological tests, with the aim to identify the clinical characteristics and co-existing factors associated with anosognosia for hemiplegia (AHP); to determine the possible existence of distinct subtypes of AHP; and to test several major theoretical accounts for AHP by performing a detailed cognitive and behavioral examination. Our results will shed new light on this puzzling disorder in brain-damaged patients, help predict the impact of such unawareness of deficit on the long-term neurological outcome, and provide new insights on brain mechanisms associated with self-awareness and self-monitoring functions.
Direct link to Lay Summary Last update: 21.02.2013

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Associated projects

Number Title Start Funding scheme
61342 Fatigue After Stroke: Neurological Correlates, Functional Impact and Quality of Life. 01.10.2000 Project funding

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