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Interventionsstudie für die Früherkennung von MRSA Trägern, mit dem Ziel der Prävention von nosokomialen MRSA Infektionen und Verbesserung der Patientensicherung

English title An interventional study to evaluate the impact of a rapid on-admission screening strategy in preventing nosocomial MRSA infection and improving patient safety
Applicant Harbarth Stephan Jürgen
Number 106294
Funding scheme NRP 49 Antibiotic resistance
Research institution Serv. Prévention et Contrôle de l’Infection Direction médicale HUG
Institution of higher education University of Geneva - GE
Main discipline Infectious Diseases
Start/End 01.07.2004 - 31.01.2007
Approved amount 140'027.00
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Keywords (5)

Nosocomial infection; antimicrobial resistance; Staphylococcus aureus; prevention; early diagnosis

Lay Summary (English)

Lead
Lay summary
An interventional study to evaluate the impact of a rapid on-admission screening strategy in preventing nosocomial MRSA infection and improving patient safety

Background
Carriage with antimicrobial-resistant pathogens such as methicillin-resistant Staphylococcus aureus (MRSA) places patients at high risk for antibiotic-resistant nosocomial infection. Early identification of patients colonized with MRSA and subsequent prevention of patient-to-patient spread through proper infection control are the most potent interventions to control MRSA. Moreover, rapid MRSA screening may improve patient safety by decreasing MRSA infection rates through directing the choice of antibiotic agents for perioperative prophylaxis and treatment. The primary focus of this proposal is early detection of colonized MRSA patients and interdiction of further cross-infection through specific preventive measures (e.g., contact isolation, topical decolonization) at a large surgical department of a Swiss university hospital.

Aim
The purpose of this research project is to test the idea that a molecular technique enabling rapid screening and early detection of MRSA carriage at a large surgical department can:
1) Substantially reduce the rate of nosocomial MRSA infection;
2) Significantly decrease the overall proportion of multi-resistant staphylococcal infections;
3) Increase individual patient safety by improving adequacy of antibiotic prophylaxis and
treatment.


Significance
This proposal allows application of a new rapid molecular technique to detect MRSA carriage on patient admission and to decrease nosocomial MRSA cross-infection. Thus, this project will promote technological development with a direct impact on daily clinical practice. Moreover, it is likely that the proposed project may help to establish recommendations for MRSA control in other hospitals. Ultimately, this work will contribute to the prevention of healthcare-associated infection and improved quality of patient care and safety.


Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

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