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In vitro, in vivo and pharmacokinetic investigations for the development of novel treatment options for food-borne trematode infections

English title In vitro, in vivo and pharmacokinetic investigations for the development of novel treatment options for food-borne trematode infections
Applicant Keiser Jennifer
Number 106221
Funding scheme Marie Heim-Voegtlin grants
Research institution Swiss Tropical and Public Health Institute
Institution of higher education University of Basel - BS
Main discipline Pharmacology, Pharmacy
Start/End 01.10.2004 - 30.09.2006
Approved amount 166'876.00
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All Disciplines (2)

Discipline
Pharmacology, Pharmacy
Tropical Medicine

Keywords (6)

Food-borne trematodes; liver flukes; lung flukes; artemisinins; synthetic peroxides (OZ); in vitro/in vivo assays

Lay Summary (English)

Lead
Lay summary
Food-borne trematode infections are an emerging, but largely unrecognizedpublic health problem, with at least 750 million people living in areas atrisk of infection. At present, treatment of food-borne trematodeinfections relies exclusively on praziquantel, yet low cure rates ofpraziquantel have been reported recently in the treatment of Clonorchissinensis. Hence there is a pressing need for research and development ofnovel drugs against food-borne trematodes. My goal is to identify a novel,broad-spectrum, orally-active single dose drug against food-bornetrematodes, derived from two promising structural families of drugs,namely the artemisinins and the synthetic peroxides (OZ) compounds. Myproposed research covers all aspects from establishing the life cycle offood-borne trematodes (Fasciola hepatica-hamster model), conducting invitro and in vivo studies, modification of lead compounds, and once a leadhas been discovered, investigations of its pharmacological properties.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

Associated projects

Number Title Start Funding scheme
114358 In vitro, in vivo and pharmacokinetic investigations for the development of novel treatment options for food-borne trematode infections 01.10.2006 Marie Heim-Voegtlin grants

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