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Evolutionary and ecological significance of colonization with multiple strains of Staphylococcus aureus in healthy carriers

English title Evolutionary and ecological significance of colonization with multiple strains of Staphylococcus aureus in healthy carriers
Applicant Sakwinska Olga
Number 106195
Funding scheme Marie Heim-Voegtlin grants
Research institution Département de Microbiologie Fondamentale Faculté de Biologie et de Médecine Université de Lausanne
Institution of higher education University of Lausanne - LA
Main discipline Ecology
Start/End 01.09.2005 - 31.08.2007
Approved amount 198'574.00
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All Disciplines (2)

Discipline
Ecology
Infectious Diseases

Keywords (4)

co-infection; co-colonization; virulence; mixed infections

Lay Summary (English)

Lead
Lay summary
Colonization and infection of hosts with multiple strains of a pathogencan affect both the pathogen and the host. Multiple infections arecrucial to the evolution of pathogen virulence and their recombinationrates. That, in turn, influences the severity of disease in the host.Staphylococcus aureus is a major human pathogen causing a variety ofinfections. It can also be carried asymptomatically by healthy people butcolonization by different strains is rarely considered. In this project,the colonization of healthy carriers with strains of Staph. aureus will bestudied by high- resolution high-throughput molecular methods. 2000isolates from 100 human carriers will be investigated. In addition, thecomparison of pathogen population structure isolated from healthy carrierswith already existing collection of hospital strains will be carried out.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

Associated projects

Number Title Start Funding scheme
118814 Evolutionary and ecological significance of colonization with multiple strains of Staphylococcus aureus in healthy carriers 01.09.2007 Marie Heim-Voegtlin grants

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