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Eine Netzwerk-Meta-Analyse pharmazeutischer Interventionen zur Schmerzbehandlung von Patienten mit Osteoarthrithis

English title A network meta-analysis of pharmaceutical interventions for pain in patients with osteoarthritis
Applicant Jüni Peter
Number 104762
Funding scheme NRP 53 Musculoskeletal Health - Chronic Pain
Research institution Institute of Social and Preventive Medicine University of Bern
Institution of higher education University of Berne - BE
Main discipline Diseases of Bones and Joints
Start/End 01.08.2004 - 31.12.2008
Approved amount 395'684.00
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All Disciplines (2)

Diseases of Bones and Joints
Methods of Epidemiology and Preventive Medicine

Keywords (5)

Osteoarthritis; Meta-Analysis; Effectiveness; Safety; Drug treatment

Lay Summary (English)

Lay summary
Pain Management in Osteoarthritis: Network Meta-Analysis

A multiplicity of drugs is used for the treatment of pain in osteoarthritis. Guidelines recommend paracetamol (e.g. Panadol®) as the first line drug, but until recently only a small number of trials was available to support its effectiveness. Recent trials suggest that nonsteroidal anti-inflammatory drugs such as diclofenac (e.g. Voltaren®) or naproxen (e.g. Apranax®) may be superior to paracetamol, but at the cost of increased rates of adverse events. Novel COX-2 selective anti-inflammatory drugs, such as Vioxx® or Celebrex®, have been increasingly used, but it is unclear whether these preparations are safer than traditional preparations.

This project aims to summarise the available clinical trial evidence for various drugs used for pain management in osteoarthritis and to perform reliable comparisons of effects and side effects of individual preparations and dosages..

Twenty-five percent of people aged 35 years or older suffer from chronic hip and knee pain, potentially requiring analgesic treatment. However, current knowledge gaps render it difficult to understand which drugs in which dosage should be used to optimise effectiveness and safety. This project aims at closing these knowledge gaps.

Direct link to Lay Summary Last update: 21.02.2013

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