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Regulation of translation initiation in the yeast Saccharomyces cerevisiae

English title Regulation of translation initiation in the yeast Saccharomyces cerevisiae
Applicant Altmann Michael
Number 104207
Funding scheme Project funding (Div. I-III)
Research institution Institut für Biochemie und Molekulare Medizin Universität Bern
Institution of higher education University of Berne - BE
Main discipline Molecular Biology
Start/End 01.04.2004 - 31.03.2008
Approved amount 216'785.00
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All Disciplines (2)

Discipline
Molecular Biology
Biochemistry

Keywords (5)

Eukaryotic translation; initiation factors of translation; regulation of translation; repressors of translation; Saccharomyces cerevisiae

Lay Summary (English)

Lead
Lay summary
From our current knowledge we can conclude that the mechanism and theregulation of translation are very conserved among all eukaryotes. Theyeast Saccharomyces cerevisiae provides a valuable system to study thefundamental steps of translation and its regulation in eukaryotes.
Repressors of protein synthesis play a very important role in helpingto regulate the metabolic activity of the cell under a variety ofnutritional and developmental conditions. A structural and functionalcharacterization of so far identified repressors and of new repressors ofprotein synthesis will help to understand this process. We propose tostudy regulation of translation by investigating the properties of theproteins p20 and Eap1 which have been previously described as repressorsof cap binding complex formation in the yeast Saccharomyces cerevisiae.Genetic screenings will be used to identify new repressors of proteinsynthesis. We will also study the properties and determine the3D-structure of YPR118w, a so far undescribed effector of proteinsynthesis.
Saccharomyces cerevisiae. p20 and Eap1 have been previouslydescribed as repressors of cap binding complex formation. We propose tostudy their RNA-binding properties which might contribute to repressoractivity. Genetic screenings will be used to identify new repressors ofprotein synthesis. We will also study the properties and determine the3D-structure of YPR118w, a so far undescribed effector of proteinsynthesis which might affect the activity of eIF2.
Direct link to Lay Summary Last update: 21.02.2013

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Associated projects

Number Title Start Funding scheme
119996 Regulation of translation initiation in the yeast Saccharomyces cerevisia 01.09.2008 Project funding (Div. I-III)

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