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The role of integrin remodeling in Kit-ligand induced melanocyte migration.

English title The role of integrin remodeling in Kit-ligand induced melanocyte migration.
Applicant Wehrle-Haller Bernhard
Number 103805
Funding scheme Project funding
Research institution Département de Pathologie et Immunologie Faculté de Médecine / CMU Université de Genève
Institution of higher education University of Geneva - GE
Main discipline Embryology, Developmental Biology
Start/End 01.05.2004 - 30.04.2007
Approved amount 216'785.00
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Keywords (6)

Melanoblasts; B16F1 melanoma; cs-1 melanoma; Kit-ligand; Stem Cell factor; Migration

Lay Summary (English)

Lay summary
Integrins are a family of cell-surface receptors that provide the mechanical connection to the extracellular matrix, which serves as a scaffold to maintain tissue integrity. The remodeling of this integrin connection is required to allow cell migration and tissue repair. In addition to providing a mechanical connection between the extracellular matrix to the intracellular protein skeleton, integrins fulfill a critical function of providing proliferation and survival signals maintaining a healthy cell population in the tissue. We have now elucidated the mechanisms that are involved in the regulation of the clustering of integrins, an important step to form mechanically stable connections, as well as serving as signaling centers. By using fluorescently tagged integrin receptors, we were the first to be able to follow the assembly and dynamic reorganization of extracellular matrix-anchored integrin complexes at the cell surface. We demonstrated that not only intracellular proteins, but also the composition of the plasma membrane played a critical role for the stabilization of these adhesive and signaling structures. Because substances such as growth factors influence the composition of plasma membranes as well as the activity of many intracellular proteins, we can now begin to predict cellular behavior based on our measurements of integrin dynamics. These informations will provide the framework and the concepts that will allow us to search for new therapeutic strategies to fight otherwise deadly conditions such as growth and invasion of cancer cells.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants


Associated projects

Number Title Start Funding scheme
116831 Control of melanocyte adhesion and spreading: Analysis of the cross-talk between Kitligand signaling and integrin adaptor recruitment 01.04.2007 Project funding
64000 Role of stem cell factor/c-kit signaling in melanocyte migration 01.04.2001 Project funding