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Inflammatory and post-inflammatory cardiomyopathy: from bench to bedside

English title Inflammatory and post-inflammatory cardiomyopathy: from bench to bedside
Applicant Eriksson Urs
Number 102849
Funding scheme SNSF Professorships
Research institution
Abteilung für Allgemeine Innere Medizin Medizinische Universitätsklinik A Universitätsspital Basel
Zentrum für Lehre und Forschung Kantonsspital Basel Onkologie
Institution of higher education University of Basel - BS
Main discipline Internal Medicine
Start/End 01.03.2004 - 29.02.2008
Approved amount 1'297'880.00
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Keywords (5)

cardiomyopathy; autoimmunity; dendritic cells; heart failure; myocarditis

Lay Summary (English)

Lead
Lay summary
Besides genetic susceptibility, microbial infections triggeringautoimmunity have been implicated in the pathogenesis of dilatedcardiomyopathy, the commonest cause of heart failure in young patients. Wehave shown that dendritic cells loaded with heart specific self-peptidesinduce CD4+ T-cell mediated myocarditis in naïve, non-transgenic mice.After resolution of acute myocarditis, mice develop heart failure. Withthis mouse model we offer a unifying theory as to how tissue damage andactivation of Toll-like receptors (TLRs) during infections can induceautoimmunity, autoimmune relapses, and cardiomyopathy. Our project willfocus on this model while studying the mechanisms involved in inductionand healing of inflammatory heart disease, as well as in mediation oftolerance. Emphasis is given that our working hypotheses are guided byclinical observations. In turn, we prompt our experimental hypotheses tolink our experimental basic research to clinical findings, and a majorgoal is the development of novel therapeutic strategies and vaccine designfor post-inflammatory heart disease and other autoimmune disorders.
Direct link to Lay Summary Last update: 21.02.2013

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Associated projects

Number Title Start Funding scheme
118988 Inflammatory and postinflammatory cardiomyopathy: from bench to bedside 01.03.2008 SNSF Professorships

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