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Analysis of the Syringolin-Triggered Tranformation of Compatibility to Incompatibilty in Powdery Mildew-Infected Plants

Applicant Dudler Robert
Number 100046
Funding scheme Project funding (Div. I-III)
Research institution Institut für Pflanzen- und Mikrobiologie Universität Zürich
Institution of higher education University of Zurich - ZH
Main discipline Botany
Start/End 01.07.2003 - 30.09.2007
Approved amount 412'725.00
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Keywords (6)

hypersensitive reaction; disease resistance; syringolin; powdery mildew; wheat; barley

Lay Summary (English)

Lay summary
Syringolin A, a product of a mixed non-ribosomal peptide/poyketide synthetase that is secreted by the phytopathogenic bacterium Pseudomonas syringae pv. syringae, triggers hypersensitive cell death at infection sites in compatible powdery mildew interactions both in wheat and Arabidopsis. Transcriptome analysis in infected and uninfected wheat and Arabidopsis showed that syringolin appears to have a conserved mode of action as similar groups of genes are activated. Analysis of the results lead to a working hypthesis about how cell death might be triggered at infection sites, according to which cell death at infection sites may result from a parasite-induced suppression of the transcriptional response which in turn would lead to insufficient production of proteins necessary for the recovery of these cells from the insult that is imposed by syringolin A. The results can be interpreted to suggest a mode of action of syringolin that will be tested. Interestingly, syringolin A was also shown to inhibit cell proliferation and to induce apoptosis in mammalian neuroblastoma and ovarian cancer cells.
Direct link to Lay Summary Last update: 21.02.2013

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Associated projects

Number Title Start Funding scheme
115970 Regulation and biosynthesis of syringolin and syringolin-like molecules and investigation of their role and mode of action in the interaction of bacteria with plants and other eukaryotes 01.10.2007 Project funding (Div. I-III)
58656 Molecular analysis of plant-pathogen interactions in cereals 01.07.2000 Project funding (Div. I-III)