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Motor threshold predicts working memory performance in healthy humans.

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Publication date 2014
Author Schicktanz Nathalie, Schwegler Kyrill, Fastenrath Matthias, Spalek Klara, Milnik Annette, Papassotiropoulos Andreas, Nyffeler Thomas, de Quervain Dominique J-F,
Project Motion and spatial neglect
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Original article (peer-reviewed)

Journal Annals of clinical and translational neurology
Volume (Issue) 1(1)
Page(s) 69 - 73
Title of proceedings Annals of clinical and translational neurology
DOI 10.1002/acn3.22


Cognitive functions, such as working memory, depend on neuronal excitability in a distributed network of cortical regions. It is not known, however, if interindividual differences in cortical excitability are related to differences in working memory performance. In the present transcranial magnetic stimulation study, which included 188 healthy young subjects, we show that participants with lower resting motor threshold, which is related to higher corticospinal excitability, had increased 2-back working memory performance. The findings may help to better understand the link between cortical excitability and cognitive functions and may also have important clinical implications with regard to conditions of altered cortical excitability.